1985
DOI: 10.2165/00003088-198510010-00001
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Comparison of Drug Dosing Methods

Abstract: The literature reviewed herein clearly demonstrates the poor correlation between drug dosing and the ability to achieve a specific serum drug concentration and between drug dosing and clinical response, especially for drugs with a narrow therapeutic index. There is, however, a better correlation between serum drug concentration and observed clinical response. Thus, clinicians use serum drug concentrations to more accurately dose drugs. Numerous dosing methods have been developed in an attempt to improve the re… Show more

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Cited by 62 publications
(16 citation statements)
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“…In no patient was there any permanent effect on renal function. The literature suggests that individualised dosing is associated with a lower incidence of nephrotoxicity compared with standard doses or physician intuition (Burton et al, 1985). Therefore greater efficacy and lower toxicity are the likely consequences of dosing using measured pharmacokinetic values.…”
Section: Discussionmentioning
confidence: 99%
“…In no patient was there any permanent effect on renal function. The literature suggests that individualised dosing is associated with a lower incidence of nephrotoxicity compared with standard doses or physician intuition (Burton et al, 1985). Therefore greater efficacy and lower toxicity are the likely consequences of dosing using measured pharmacokinetic values.…”
Section: Discussionmentioning
confidence: 99%
“…Methods for predicting serum levels have been received. 27 The aim of an effective dosing regimen is to produce a constant plasma concentration of theophylline. Nonetheless.…”
Section: Mode Of Actionmentioning
confidence: 99%
“…The methodologies which have been described range from predictive algorithms and nomograms, through manipulations of the standard Michaelis-Menten equations and population-clearance models, to methods which incorporate Bayesian principles. This article adds more recent information to the original review of Burton et al (1985) which included literature on phenytoin dosing methods up to 1984; a similar format of predictive algorithms, pharmacokinetics-based dosing methods and Bayesian feedback techniques is followed.…”
Section: Phenytoinmentioning
confidence: 99%