Comparison of drug delivery with autoinjector versus manual prefilled syringe and between three different autoinjector devices administered in pig thigh

Hill, Robert L.; Wilmot, John G; Belluscio, Beth A.; Cleary, Kevin; Lindisch, David; Tucker, Robin D.; Wilson, Emmanuel; Shukla, Rajesh B.

doi:10.2147/mder.s83406

Cited by 14 publications

(5 citation statements)

References 15 publications

(13 reference statements)

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“…The use of single needle or multi-needle injection designs are possible approaches to meet these metrics. Opinions of medical experts and experimental studies indicate that administration of SC or IM therapies exceeding volumes of 1–2 mL can cause significant pain that leads to reduced patient compliance( Berteau et al, 2010 , 2015 ; Gupta et al, 2011 ; Hill et al, 2016 ; Kim et al, 2012 ). Thus, the larger volume of injection described necessitates the use of either lower injection/infusion rates or the distribution of the injection volume over a larger surface are.…”

Section: Im or Sc Administration Of Sbe Therapies Using A Medical Devicementioning

confidence: 99%

Considerations for the development of a field-based medical device for the administration of adjunctive therapies for snakebite envenoming

Werner,

Soffa

2023

Toxicon: X

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Section: Im or Sc Administration Of Sbe Therapies Using A Medical Devicementioning

confidence: 99%

Considerations for the development of a field-based medical device for the administration of adjunctive therapies for snakebite envenoming

Werner,

Soffa

2023

Toxicon: X

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“…Але результати дослідження вказують на високий рівень переваг та перспектив у застосуванні ЛЗ у АІ/ПЗШР у медичній практиці як для персоналу, так і для пацієнтів. Н. В. Шолойко 1 (https://orcid.org/0000-0002-5083-7218), А. О. Гончар 2 (https://orcid.org/0000-0002-2088-0645), Т. І. Лисенко 1 (https://orcid.org/0000-0003-2462-0047) 1 Державний експертний центр МОЗ України, м. Київ 2 Національний медичний університет імені О. О. Богомольця, м. Київ ПЕРЕВАГИ ТА ПЕРСПЕКТИВИ ЗАСТОСУВАННЯ ЛІКАРСЬКИХ ЗАСОБІВ У ВИГЛЯДІ АВТОІНЖЕКТОРІВ ТА ПОПЕРЕДНЬО ЗАПОВНЕНИХ ШПРИЦ-РУЧОК Ключові слова: автоінжектор, попередньо заповнена шприц-ручка, лікарський засіб, маркетинговий аналіз А Н О Т А Ц І Я Сьогодні існує потреба у впровадженні в повсякденну лікарську практику медичних виробів для самостійного введення ін'єкційних лікарських засобів (ЛЗ). Швидкість та безпечність застосування автоінжекторів/попередньо заповнених шприц-ручок (АІ/ПЗШР) -це ін'єкційна форма ЛЗ, у спеціальному медичному виробі, що дозволяє вводити пацієнтам попередньо зазначену терапевтичну дозу за рахунок особливостей будови виробу, за рахунок автоматичного дозування, даних інтерактивного дисплею на деяких приладах, зручного дизайну та ін.…”

Section: рис 3 рівень поширеності попередньо заповнених шприц-ручокunclassified

“…Важливу роль можуть відігравати різні параметри як звичайних шприців, так і АІ/ПЗШР, включаючи в'язкість рідини ЛЗ, довжину голки, тертя між поршнем шприца та його поверхнею тощо. Тому були створені моделі АІ, які мають внутрішню прожину, яка стискається перед активацією і відпускається натисненням кнопки [1].…”

unclassified

“…Н. В. Шолойко 1 (https://orcid.org/0000-0002-5083-7218), А. А. Гончар 2 (https://orcid.org/0000-0002-2088-0645), Т. И. Лысенко 1 (https://orcid.org/0000-0003-2462-0047) 1 Государственный экспертный центр МЗ Украины, г. Киев 2 Национальный медицинский университет имени А. А. Богомольца, г. Киев ПРЕИМУЩЕСТВА И ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ ЛЕКАРСТВ В АВТОИНЖЕКТОРАХ И ПРЕДВАРИТЕЛЬНО ЗАПОЛНЕННЫХ ШПРИЦ-РУЧКАХ Ключевые слова: автоинжектор, предварительно заполненная шприц-ручка, лекарственные средства, маркетинговый анализ А Н Н О Т А Ц И Я Сегодня существует необходимость во внедрении в повседневную врачебную практику медицинских изделий с целью самостоятельного введения инъекционных лекарственных средств (ЛЗ). Скорость и безопасность применения автоинжекторов/предварительно заполненных шприц-ручек (АИ/ПЗШР) -это введение инъекционной формы ЛЗ в специальном медицинском изделии, что позволяет вводить пациентам предварительно обозначенную терапевтическую дозу за счет особенностей строения изделия, автоматического дозирования, данных интерактивного дисплея на некоторых устройствах, удобного дизайна и т.д.…”

unclassified

“…Но результаты исследования указывают на высокий уровень преимуществ и перспектив в применении ЛС в АИ/ПЗШР в медицинской практике как для персонала так и для пациентов. N. V. Sholoyko 1 (https://orcid.org/0000-0002-5083-7218), A. O. Gonchar 2 (https://orcid.org/0000-0002-2088-0645), T. I. Lysenko 1 (https://orcid.org/0000-0003-2462-0047) 1 The State The State Expert Center of the MoH of Ukraine, Kyiv 2 Bohomolets National Medical University, Kyiv ADVANTAGES AND PERSPECTIVES OF USING MEDICINES IN THE FORM OF AUTO INJECTORS AND PREFILLED SYRINGES Key words: autoinjector, pre-filled syringe pen, drug, marketing analysis А B S T R A C T Today, there is a need to introduce medical devices into everyday medical practice with the goal to selfadminister injectional drugs. The speed and safety of auto-injectors / pre-filled syringe pens use (AI/PFS) is the introduction of an injectional form drug in a special medical device, which allows patients to enter a predesignated therapeutic dose due to the characteristics of the structure of the product, automatic dosing, data of the interactive display on some devices, comfortable design, etc.…”

mentioning

confidence: 99%

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Advantages and perspectives of using medicines in the form of auto injectors and prefilled syringes

Sholoyko¹,

Gonchar

Lysenko³

2019

Farm Zh

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Today, there is a need to introduce medical devices into everyday medical practice with the goal to self-administer injectional drugs. The speed and safety of auto-injectors / pre-filled syringe pens use (AI/PFS) is the introduction of an injectional form drug in a special medical device, which allows patients to enter a pre-designated therapeutic dose due to the characteristics of the structure of the product, automatic dosing, data of the interactive display on some devices, comfortable design, etc. Considering that AI/PFS were developed to improve the quality of life of patients with various pathological conditions, therefore the creation of affordable medical devices for low-income groups of the population is relevant today. Also an actual issue is the provision of high-quality first-aid kits for soldiers, which is a vital component for medical care in the context of active combat conditions and the lack of the required number of field hospitals.The speed of administration, the onset of effect and ease of use provides significant advantages for AI / PFS. Therefore, the issue of affordability for the low-income groups of the population and the army with the necessary drugs should be sufficiently supported by state regulation.Purpose of study – study of the international experience in the implementation and use of drugs (drugs) in the form of affordable, safe and effective modern dosage forms in the form of autoinjectors.Materials and methods – foreign and domestic literature on the use of AI/PFS in complex and monotherapy treatment of various diseases. State registries of medicines of Ukraine, the USA and some EU countries. The study used systematic, statistical and comparative analyzes, as well as the generalization of information. The data used is freely available among various medical scientific and metric bases, the Internet and international scientific conferences.The analysis of the use of AI/PFS indicates that today the world market of medicines and medical devices contains a large number of drugs under different trade names. However, many patients in the world refrain from using these dosage forms due to the significant cost of medical devices, which makes impossible the required regular use of such drugs for the low-income population groups. This is a significant disadvantage, since AI / PFS is implemented to correct not only chronic diseases such as rheumatoid arthritis, multiple sclerosis, but also to provide emergency careinurgent conditions (anaphylactic reactions, intense pain, etc.).In the global market for drugs and medical devices, injectable medicines in the form of AI/PFS are widely represented. The effectiveness of the use of such devices indicates the advantages and prospects for the use of existing AI/PFS on the global market for patients and medical personnel. Today, the most commonly used drugs in AI/PFSare for the treatment of diabetes, emergency conditions in civil and military medicine, chronic diseases of various etiologies, pediatric practice. The use of AI /PFS significantly improves patient compliance for the treatment of chronic diseases due to ease of use and reduction of adverse reactions at the site of administration. Most of the analyzed sources indicate a low level of economic affordability of drugs in the form of AI/PFS for the population and the government sector of drug supply due to the high cost of the medical devices, compared to traditional syringes. But the results of the study indicate a high level of advantages and prospects in the use of drugs in AI/PFS in medical practice for both medical personnel and patients.

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Adrenaline auto injectors pharmacokinetic/pharmacodynamic studies and potential consequences for clinical practice

Worm,

Fox,

Wickman

et al. 2023

Clinical & Translational All

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BackgroundAnaphylaxis is a sudden multisystem allergic reaction which may result in a fatal outcome if not treated promptly. Guidelines worldwide suggest intramuscular adrenaline as the first‐line treatment for anaphylaxis outside a perioperative reaction. Adrenaline autoinjectors (AAIs) are widely used self‐administrable devices, especially in community settings. Different commercial AAIs have been authorized to be marketed in Europe. For an AAI to be efficacious, a rapid adrenaline delivery in patients, including those who are overweight or obese, resulting in an optimal cardiovascular (CV) response, is a key feature. AAIs are designed to achieve this requirement, which is reflected in their differing functional properties such as primary container selection, drug delivery mechanism (cartridge‐or syringe‐based), needle length, needle gauge, and adrenaline dose (150 μg, 300 μg, or 500 μg). However, the differences in functional properties across these devices may play a critical role in achieving these requirements as well as the differences in ergonomics in the handling of these devices.The purpose of this reviewConsidering the dynamic pharmacokinetic/pharmacodynamic (PK/PD) profiles of different AAIs marketed in Europe and their effect on adrenaline delivery, the expert panel, also serving as author for this paper have carried out a detailed analysis of the PK/PD profiles of four AAIs, namely, Anapen, Emerade, EpiPen, and Jext, to delineate the adrenaline delivery and their subsequent physiological effects on the backdrop of device characteristics, dose strength, and the skin‐to‐muscle distances of the participants.

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Comparison of drug delivery with autoinjector versus manual prefilled syringe and between three different autoinjector devices administered in pig thigh

Cited by 14 publications

References 15 publications

Considerations for the development of a field-based medical device for the administration of adjunctive therapies for snakebite envenoming

Considerations for the development of a field-based medical device for the administration of adjunctive therapies for snakebite envenoming

Advantages and perspectives of using medicines in the form of auto injectors and prefilled syringes

Adrenaline auto injectors pharmacokinetic/pharmacodynamic studies and potential consequences for clinical practice

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