Comparison of dose-time–fractionation schemes in non-oat cell lung cancer

Abstract

A series of 205 patients with inoperable, non-oat cell carcinoma of the lung were treated with thrdk different dose-fractionation schedules. Fifty-six patients received 5000 rads in 25 fractions over five weeks (continuous, A); 79 patients received 2000 rads in five fractions over five days, with two weeks' rest, followed by 2000 rads in five fractions over five days (split-course, B); 70 patients received 3000 rads in 10 fractions over two weeks, followed by three weeks' rest and another 3000 rads (split-course, C). The 24-month survival was 33% for A, 15% for B and 25% for C. The split course was better tolerated and radiation fibrosis was dose-related.

Preoperative radiation may improve the outcomes of resectable IIIA/N2 non‐small‐cell lung cancer patients: A propensity score matching‐based analysis from surveillance, epidemiology, and end results database

“…More than one‐third of NSCLC patients presented with locally advanced tumors, without distant metastatic disease, which could not be primarily resected . Radiotherapy is usually used as the primary local treatment but has associated unsatisfying survival rates . Locally recurrent tumors and their complications account for about 75% of the deaths in patients with epidermoid lung cancer, and approximately 40% of the deaths in patients with other histologic subtypes of NSCLC .…”

“…16 Radiotherapy is usually used as the primary local treatment but has associated unsatisfying survival rates. [17][18][19][20] Locally recurrent tumors and their complications account for about 75% of the deaths in patients with epidermoid lung cancer, and approximately 40% of the deaths in patients with other histologic subtypes of NSCLC. 21,22 To have an impact on the overall outcome of the management of patients with localized NSCLC, one should make an attempt to decrease the probability of local failure as well as distant metastasis.…”