Comparison of dose-response curves between acid and pepsin to betazole hydrochloride in the dog with gastric fistula

Ishimori, Akira; Sakurada, H.; Kawamura, Takeshi; Yamagata, Shoichi; Miura, Yohei

doi:10.1007/bf02776656

Cited by 33 publications

(2 citation statements)

References 9 publications

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“…A new synthesis of betazole was described by Jones and Mann [8,9] and also enzymatic formation of it was reported [10]. In the literature ample number of articles exist about the medicinal aspects of betazole [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

DFT Treatment of Betazole Tautomerism

Türker

2023

EJCS

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Betazole belongs to pyrazole type medicines and selectively targets and binds to the H2-type receptors. Tautomerism can only be demonstrated in pyrazole derivatives and not in the pyrazole itself. In the present density functional treatment of tautomers of betazole (within the constraints of density functional theory) calculations have been performed at the level of B3LYP/6-311++G(d,p). Betazole may exhibit 1,3- and 1,5-type proton tautomerism involving pyrazole ring system so that in some tautomers aromaticity of the ring is destroyed. The results have revealed that all the tautomers possess thermo chemically favorable formation values at the standard conditions and are electronically stable. Some quantum chemical and spectral properties of those tautomeric systems as well as nucleus independent chemical shift (NICS) values for the aromatic ones have been obtained and discussed.

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Section: Introductionmentioning

confidence: 99%

DFT Treatment of Betazole Tautomerism

Türker

2023

EJCS

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“…On the other hand, histamine and its chemical derivative, betazole hydrochloride, were known to stimulate gastric acid and pepsin secretion [5][6][7], It was hypothesized that, in the underlying mechanism, histamine bound to H:-receptor stimulated the adenyl ate cyclase-cyclic AMP system so as to ele vate the cellular cyclic AMP. which then enhanced acid secretion [8], However, the cellular mechanism by which histamine or betazole hydrochloride stimulates pepsi-…”

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Effects of Betazole Hydrochloride and Cyclic AMP on the Pepsinogen Secretion by Rabbit Gastric Mucosa in Organ Culture

Itō¹,

Noguchi²,

Yokochi³

et al. 1982

Digestion

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The effects of betazole hydrochloride, dibutyryl cyclic AMP (DB-cyclic AMP) and betazole hydrochloride plus aminophylline on pepsinogen secretion by rabbit gastric mucosa were studied in organ culture. Betazole hydrochloride alone did not stimulate pepsinogen secretion at the concentrations of 10^-8, 10^-6, 10^-5 and 10^-4M. However, 10^-3M DB-cyclic AMP produced a significant stimulation of pepsinogen secretion into the culture medium when compared with the control. In the presence of 3 × 10^-3M aminophylline, betazole hydrochloride in the concentration of 10^-5 and 10^-4M stimulated pepsinogen secretion into the culture medium, and the magnitude of this increase was 2.0- and 2.8-fold, respectively, compared with the control. Aminophylline alone could not change pepsinogen secretion into the culture medium. These results suggested that the pepsinogen secretion, stimulated by betazole hydrochloride, was mediated by cyclic AMP in the chief cells.

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A combined treatment approach to management of hepatic metastases

Webber

Soderberg

Leone

et al. 1978

Cancer

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Forty-eight patients with liver metastases were treated at Rhode ISland Hospital in a nonrandomized sequential manner between January 1972 and June 1977. Eight received 5 FUDR hepatic artery infusion, 14 hepatic irradiation, and 25 were planned for combined intra-arterial chemotherapy plus total hepatic irradiation. Those patients who successfully completed induction treatments had a median survival in the radiation only group of 140 days, in the intra-arterial chemotherapy group 270 days, and in the combined group 376 days. Hepatic radiation when combined with chemotherapy was well tolerated. Primary tumor site, disease duration, and degree of abnormality of liver function had no relationship to the response to treatment. The pretreatment performance level of the patient as determined by the Karnofsky Performance Index gave the best indication for potential response to combined therapy. Based on the results of this treatment and the reports of other series, it appears that the combination of intra-arterial 5 FUDR plus hepatic irradiation may offer prolonged and worthwhile palliation to appropriately chosen patients.

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Comparison of dose-response curves between acid and pepsin to betazole hydrochloride in the dog with gastric fistula

Cited by 33 publications

References 9 publications

DFT Treatment of Betazole Tautomerism

DFT Treatment of Betazole Tautomerism

Effects of Betazole Hydrochloride and Cyclic AMP on the Pepsinogen Secretion by Rabbit Gastric Mucosa in Organ Culture

A combined treatment approach to management of hepatic metastases

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