Comparison of disc and body volumes in degenerated and nondegenerated lumbar discs: a stereological study

Kaner, Tuncay; Songür, Ahmet; Toktaş, Muhsin; Alkoç, Ozan Alper; Eser, Olcay; Efendioğlu, Mustafa

doi:10.3906/sag-1208-45

Cited by 2 publications

(3 citation statements)

References 38 publications

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“…In our study, both the volume and disc height decreased with the disc degeneration progression, this is consistent with the experimental findings (Kaner et al, 2014; Peloquin et al, 2014; Pfirrmann et al, 2006). The volume decrease was mainly caused by the reduction in the swelling pressure and the loss of the water in the disc, especially in the NP region and the inner AF regions (Fig.…”

Section: Discussionsupporting

confidence: 93%

Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression

Zhu

Gao

2014

Journal of Biomechanics

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In this study, a three-dimensional finite element model was used to investigate the changes in tissue composition and mechanical signals within human lumbar intervertebral disc during the degenerative progression. This model was developed based on the cell-activity coupled mechano-electrochemical mixture theory. The disc degeneration was simulated by lowering nutrition levels at disc boundaries, and the temporal and spatial distributions of the fixed charge density, water content, fluid pressure, Von Mises stress, and disc deformation were analyzed. Results showed that fixed charge density, fluid pressure, and water content decreased significantly in the nucleus pulposus (NP) and the inner to middle annulus fibrosus (AF) regions of the degenerative disc. It was found that, with degenerative progression, the Von Mises stress (relative to that at healthy state) increased within the disc, with a larger increase in the outer AF region. Both the disc volume and height decreased with the degenerative progression. The predicted results of fluid pressure change in the NP were consistent with experimental findings in the literature. The knowledge of the variations of temporal and spatial distributions of composition and mechanical signals within the human IVDs provide a better understanding of the progression of disc degeneration.

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Section: Discussionsupporting

confidence: 93%

Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression

Zhu

Gao

2014

Journal of Biomechanics

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“…5 Due to the annulus fibrosus tearing on the disc herniation, the waterholding function of the nucleus pulposus is impaired and consequently, the disc volume may change. 6 There is a limited number of publications in the literature about whether disc herniation affects spinal ganglia volume at the relevant level and side. 7 In another study, there was no significant relationship between the presence of disc herniation and spinal ganglion size.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, T1-T2 weighted sagittal MR images were examined for volume determination using the Cavalieri method. 6 Using the Cavalieri principle, volume detection can be done with MR images as well as CT images. 5,14,15 In the absence of a CT computer system, the Cavalieri principle was found to be useful in calculating the volume of lumbar intervertebral discs.…”

Section: Discussionmentioning

confidence: 99%

The estimation of lumbar intervertebral disc volumes before and after exercise using the Cavalieri method

Özdikici

2018

MOJAP

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Purpose: Our aim in this study is to determine the volume differences of the lumbar intervertebral discs by using the Cavalieri method. Subjects and methods: In our study, lumbar magnetic resonance imaging (MRI) was performed on 20 male (mean age, 22 years; age range, 19-25 years) athletes without any known disease on the lumbar vertebra and discs immediately after resting and after a 50-minute loading exercise. The lumbar intervertebral disc volumes were measured by Cavalieri method and compared after resting and after exercise. Statistical analyses of the results were carried out to evaluate changes in the disc volume. Results: The mean volume of the three lower lumbar intervertebral discs (L2-L3, L3-L4, L4-L5) was 17 centimetres cube after resting and 15 centimetres cube after exercise. Total volume decreased from 51 centimetres cube to 45 centimetres cube. After a 50-minute loading exercise, a 12% reduction was detected (p<0.05). Conclusion: The reduction in the lumbar intervertebral disc volumes after exercise may be useful in providing predictive short-term information through the Cavalieri method.

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Comparison of disc and body volumes in degenerated and nondegenerated lumbar discs: a stereological study

Cited by 2 publications

References 38 publications

Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression

Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression

The estimation of lumbar intervertebral disc volumes before and after exercise using the Cavalieri method

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