Comparison of Dinoprostone Vaginal Tablet and Vaginal Insert in Primigravid Women for Induction of Labor

Ishaqui, Azfar Athar; Shabkah, Shadi Adnan; Hаssаn, Wаfаа S.; Akbar, Zahida; Arab, Mohammad Al; Shabkah, Reema Adnan; Haq, Inam

doi:10.14740/jcgo471w

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study in Saudi Arabia also found no difference in two preparations. 6 Indian studies also find no advantage in IDI and vaginal delivery rate. 7 However, few studies demonstrated more vaginal delivery with insert.…”

Section: Discussionmentioning

confidence: 94%

“…4 There are two meta-analyses on the efficacy of Dinoprostone vaginal pessary for labor induction. Sanchez-Ramos et al 5 reviewed four clinical trials and concluded that the vaginal insert was "less effective than other prostaglandins for cervical ripening and labor induction," whereas the conclusion reached by Hassan et al 6 was that vaginal insert is equally effective as other prostaglandin routes of administration in terms of delivery by 24 hours, rate of uterine hyperstimulation with fetal heart rate changes and cesarean delivery rate. A study in Saudi Arabia also found no difference in two preparations.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison between Two Preparations of Dinoprostone (PGE2)-pessary and Gel for Induction of Labor at Term

Malik¹,

Singh²,

Tandon³

2022

Journal of South Asian Federation of Obstetrics and Gynaecology

View full text Add to dashboard Cite

Background: There are multiple inducing agents available-pharmacological and non-pharmacological. The search for an ideal inducing agent continues worldwide. An ideal inducing agent should have less induction interval to delivery time, less side effects such as fetal distress and hyperstimulation, patient safety, economical, and have ease of administration. The two preparations of Dinoprostone (PGE2) gel and pessary were compared for efficacy in vaginal delivery, induction delivery interval (IDI), and cost effectiveness. Materials and methods: A prospective observational study was done in 100 patients in a tertiary level teaching hospital from 1 November 2019 to 31 March 2021. A total of 50 patients in group A received 0.5-mg PGE2 gel and 50 patients in group B had insertion of sustained release 10-mg PGE2 pessary for induction of delivery at term. The two groups were compared for the rate of vaginal delivery and IDI. Other variables, such as need of augmentation, fetal distress, postpartum haemorrhage (PPH), and neonatal intensive care unit (NICU) admission, were also compared. Results:The rate of vaginal delivery in both groups were similar. Mean induction to vaginal delivery interval was significantly lesser in the Dinoprostone pessary group (17.72 ± 6.81 hours for PGE2 pessary group vs 19.57 ± 5.46 hours for PGE2 gel group); duration of augmentation with Oxytocin was significantly lesser in the pessary group (5.68 ± 4.05 hours in pessary group vs 7.41 ± 3.44 hours in gel group). There was no significant difference in failed induction, uterine hyperstimulation, fetal distress, PPH, and NICU admission in the two groups. Conclusion: Dinoprostone gel and pessary are similar in rate of vaginal delivery. The IDI and need of oxytocin are less with PGE2 pessary. Failure rate is same for both PGE2 pessary and gel. In comparison, no marked superiority of pessary was seen over economical gel preparation.

show abstract

Section: Discussionmentioning

confidence: 94%