Comparison of diffusion kurtosis imaging and dynamic contrast enhanced MRI in prediction of prognostic factors and molecular subtypes in patients with breast cancer

Wang, Weiwei; Lv, Siqiang; Xun, Jing; Wang, Lei; Zhao, Fan; Wang, Jiehuan; Zhou, Zhe; Chen, Yue‐Qin; Sun, Zhanguo; Zhu, Laimin

doi:10.1016/j.ejrad.2022.110392

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…Jung et al found that K trans was the most signi cant parameter for distinguishing high-and lowgrade gliomas [16]. Another study found mean K trans is higher in breast cancer with high histologic than that in breast cancer with low histologic grade [17]. In this study, we did not nd that Kep and Ve were related to the differentiation of rectal cancer.…”

Section: Discussioncontrasting

confidence: 76%

Quantitative Dynamic Contrast-Enhance MRI Parameters for Rectal Carcinoma Characterization: Correlation with Tumor Tissue Composition

Yuan

Liu

Zhang

et al. 2023

Preprint

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Objective To investigate the relationship between dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) measurements and the potential composition of rectal carcinoma. Methods Twenty-four patients provide informed consent for this study. DCE MRI was performed before total mesorectal excision. Quantitative parameters were calculated based on a modified Tofts model. Whole-mount immunohistochemistry and Masson staining sections were generated and digitized at histological resolution. The percentage of tissue components area was measured. Pearson correlation analysis was used to evaluate the correlations between pathological parameters and DCE MRI parameters. Results On the World Health Organization (WHO) grading scale, there were significant differences in extracellular extravascular space (Ktrans) (F = 9.890, P = 0.001), mean transit time (MTT) (F = 9.890, P = 0.038), CDX-2 (F = 4.935, P = 0.018) and Ki-67 (F = 4.131, P = 0.031) among G1, G2, and G3. ECV showed significant differences in extramural venous invasion (t=-2.113, P = 0.046). Ktrans was strongly positively correlated with CD34 (r = 0.708, P = 0.000) and moderately positively correlated with vimentin (r = 0.450, P = 0.027). Interstitial volume (Ve) was moderately positively correlated with Masson’s (r = 0.548, P = 0.006) and vimentin (r = 0.417, P = 0.043). There was a moderate negative correlation between Ve and CDX-2 (r=-0.441, P = 0.031). The rate constant from extracellular extravascular space to blood plasma (Kep) showed a strong positive correlation with CD34 expression (r = 0.622, P = 0.001). ECV showed a moderate negative correlation with CDX-2 (r=-0.472, P = 0.020) and a moderate positive correlation with collagen fibers (r = 0.558, P = 0.005). Conclusion The dynamic contrast-enhanced MRI-derived parameters measured in rectal cancer were significantly correlated with the proportion of histological components. This may serve as an optimal imaging biomarker to identify tumor tissue components.

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Section: Discussioncontrasting

confidence: 76%

Quantitative Dynamic Contrast-Enhance MRI Parameters for Rectal Carcinoma Characterization: Correlation with Tumor Tissue Composition

Yuan

Liu

Zhang

et al. 2023

Preprint

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“…MK can evaluate the extent to which the water molecules with the diffusion displacement distribution deviate from the Gaussian function, reflecting the complexity of the tissue microstructure, the more complex the tissue structure of the selected ROI, the more restricted the water molecules have in their diffusion, and the larger the MK. [6,[14][15][16] According to the results of previous [10,14,17] studies in the literature, The ADC and MD values of the benign lesions were higher than the malignant lesions, and The MK values were higher in malignant lesions than in benign lesions, data from the current study showed that, The ADC value and MD of the benign lesions of the 2 test subjects, which were 1.63 ± 0.5210 to 3 m m2/seconds and 1.54 ± 0.4510 to 3 mm2/seconds, respectively; 2.23 ± 0.37 × 10 to 3 mm2/seconds, 2.21 ± 0.37 × 10 to 3 mm2/seconds, The ADC values and MD values of the malignant lesions were 1.27 ± 0.4510 to 3 mm2/seconds, and 1.27 ± 0.4510 to 3 mm2/seconds, respectively; 1.86 ± 0.54 × 10 to 3 mm2/seconds, 1.79 ± 0.52 × 10 to 3 mm2/seconds, The MK values for benign lesions were 0.46 ± 0.25 and 0.46 ± 0.24, The MK values for the malignant lesions were 0.67 ± 0.19 and 0.59 ± 0.23, Consistent with previous literature reports. In this study, the diagnostic efficacy of MK, MD, and ADC values in malignant breast lesions were all evaluated using the ROC curves.…”

Section: Discussionmentioning

confidence: 99%

The outstanding diagnostic value of DKI in multimodal magnetic resonance imaging for benign and malignant breast tumors: A diagnostic accuracy study

Gao,

Wang,

Zhang

et al. 2023

Medicine

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To explore the value of applying different magnetic resonance imaging MRI sequences in the differential diagnosis of benign and malignant breast tumors. Routine breast magnetic resonance scans (T1-weighted image, T1WI; T2-weighted image, T2WI), dynamically enhanced scans, diffusion-weighted Imaging, and diffusion kurtosis imaging (DKI) scans were performed on 63 female patients with breast-occupying lesions. The benign and malignant lesions were confirmed by biopsy, excision-histopathology reports. There are 70 lesions, of which 46 are benign and 24 are malignant. Analyze the primary conditions, such as the shape, size, and boundary of the lesion, and determine the apparent diffusion coefficient (ADC), mean kurtosis (MK), and mean diffusion (MD) values. The receiver operating characteristic curve was used to evaluate the value and difference in differentiating benign and malignant lesions. In this study, the results of the 2 testers both showed that the MK of malignant lesions was significantly higher than that of benign lesions (P < .001), and the MD of benign lesions was higher than that of malignant lesions (P < .05). The ADC of benign lesions was higher than that of malignant lesions (P < .05). For MK, the area under the curve of the 2 testers was 0.855/0.869, respectively. When the best cutoff value of MK for tester 1 was 0.515, the sensitivity and specificity of MK for diagnosing malignant tumors were 83.3%/87.0%, respectively. For the 2 testers MD, and ADC, the area under the curve was < 0.5, and the diagnostic value was low. The MK value obtained by DKI has a specific value in the differential diagnosis of benign and malignant breast lesions. DKI is helpful in the identification of benign and malignant breast tumors. The diagnostic value is outstanding, and its importance to the changes in the microstructure of the organization needs to be further explored.

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“…Jung et al found that K trans was the most significant parameter for distinguishing high- and low-grade gliomas [ 16 ]. Another study found mean K trans is higher in breast cancer with high histologic than that in breast cancer with low histologic grade [ 17 ]. In this study, we did not find that Kep and Ve were related to the differentiation of rectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Quantitative dynamic contrast-enhance MRI parameters for rectal carcinoma characterization: correlation with tumor tissue composition

Yuan,

Liu,

Zhang

et al. 2023

World J Surg Onc

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Objective To investigate the relationship between dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) measurements and the potential composition of rectal carcinoma. Methods Twenty-four patients provided informed consent for this study. DCE-MRI was performed before total mesorectal excision. Quantitative parameters were calculated based on a modified Tofts model. Whole-mount immunohistochemistry and Masson staining sections were generated and digitized at histological resolution. The percentage of tissue components area was measured. Pearson correlation analysis was used to evaluate the correlations between pathological parameters and DCE-MRI parameters. Results On the World Health Organization (WHO) grading scale, there were significant differences in extracellular extravascular space (Ktrans) (F = 9.890, P = 0.001), mean transit time (MTT) (F = 9.890, P = 0.038), CDX-2 (F = 4.935, P = 0.018), and Ki-67 (F = 4.131, P = 0.031) among G1, G2, and G3. ECV showed significant differences in extramural venous invasion (t = − 2.113, P = 0.046). Ktrans was strongly positively correlated with CD34 (r = 0.708, P = 0.000) and moderately positively correlated with vimentin (r = 0.450, P = 0.027). Interstitial volume (Ve) was moderately positively correlated with Masson’s (r = 0.548, P = 0.006) and vimentin (r = 0.417, P = 0.043). There was a moderate negative correlation between Ve and CDX-2 (r = − 0.441, P = 0.031). The rate constant from extracellular extravascular space to blood plasma (Kep) showed a strong positive correlation with CD34 expression (r = 0.622, P = 0.001). ECV showed a moderate negative correlation with CDX-2 (r = − 0.472, P = 0.020) and a moderate positive correlation with collagen fibers (r = 0.558, P = 0.005). Conclusion The dynamic contrast-enhanced MRI-derived parameters measured in rectal cancer were significantly correlated with the proportion of histological components. This may serve as an optimal imaging biomarker to identify tumor tissue components.

show abstract

Comparison of diffusion kurtosis imaging and dynamic contrast enhanced MRI in prediction of prognostic factors and molecular subtypes in patients with breast cancer

Cited by 9 publications

References 43 publications

Quantitative Dynamic Contrast-Enhance MRI Parameters for Rectal Carcinoma Characterization: Correlation with Tumor Tissue Composition

Quantitative Dynamic Contrast-Enhance MRI Parameters for Rectal Carcinoma Characterization: Correlation with Tumor Tissue Composition

The outstanding diagnostic value of DKI in multimodal magnetic resonance imaging for benign and malignant breast tumors: A diagnostic accuracy study

Quantitative dynamic contrast-enhance MRI parameters for rectal carcinoma characterization: correlation with tumor tissue composition

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