Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography

Konecky, Soren D.; Choe, Regine; Corlu, Alper; Lee, Kijoon; Wiener, R. I.; Srinivas, Shyam; Saffer, Janet; Freifelder, R.; Karp, Joel S.; Hajjioui, Nassim; Azar, Fred S.; Yodh, Arjun G.

doi:10.1118/1.2826560

Cited by 33 publications

(21 citation statements)

References 55 publications

(47 reference statements)

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“…Other approaches based on spectroscopic differences of Hb and HbO 2 have been proposed as well (19). Notably, diffuse optical tomography (45) was used to reconstruct 3D oxygen distribution in breast cancer patients (150). The method has limited tissue penetration and is confined in body parts with a relatively low light attenuation (291).…”

mentioning

confidence: 99%

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

Walsh

Lebedev

Aten³

et al. 2014

Antioxidants & Redox Signaling

330

317

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Tumor hypoxia is a well-established biological phenomenon that affects the curability of solid tumors, regardless of treatment modality. Especially for head and neck cancer patients, tumor hypoxia is linked to poor patient outcomes. Given the biological problems associated with tumor hypoxia, the goal for clinicians has been to identify moderately to severely hypoxic tumors for differential treatment strategies. The ''gold standard'' for detecting and characterizing of tumor hypoxia are the invasive polarographic electrodes. Several less invasive hypoxia assessment techniques have also shown promise for hypoxia assessment. The widespread incorporation of hypoxia information in clinical tumor assessment is severely impeded by several factors, including regulatory hurdles and unclear correlation with potential treatment decisions. There is now an acute need for approved diagnostic technologies for determining the hypoxia status of cancer lesions, as it would enable clinical development of personalized, hypoxia-based therapies, which will ultimately improve outcomes. A number of different techniques for assessing tumor hypoxia have evolved to replace polarographic pO 2 measurements for assessing tumor hypoxia. Several of these modalities, either individually or in combination with other imaging techniques, provide functional and physiological information of tumor hypoxia that can significantly improve the course of treatment. The assessment of tumor hypoxia will be valuable to radiation oncologists, surgeons, and biotechnology and pharmaceutical companies who are engaged in developing hypoxia-based therapies or treatment strategies. Antioxid. Redox Signal. 21, 1516-1554.

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mentioning

confidence: 99%

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

Walsh

Lebedev

Aten³

et al. 2014

Antioxidants & Redox Signaling

330

317

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“…Therefore, some researchers are studying non-concurrent multimodal measurement, although it is challenging to register between two breast images with different deformation [69] . Promising results using the non-concurrent image registration have been reported between bPET and DOI [70] .…”

Section: Multimodal Assessment Of Breast Cancermentioning

confidence: 93%

Optical mammography: Diffuse optical imaging of breast cancer

Lee¹

2011

WJCO

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Existing imaging modalities for breast cancer screening, diagnosis and therapy monitoring, namely X-ray mammography and magnetic resonance imaging, have been proven to have limitations. Diffuse optical imaging is a set of non-invasive imaging modalities that use near-infrared light, which can be an alternative, if not replacement, to those existing modalities. This review covers the background knowledge, recent clinical outcome, and future outlook of this newly emerging medical imaging modality.

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“…Furthermore, the registration of FDG-PET and optical breast imaging provides the ability to quantify total hemoglobin, blood oxygenation, and glucose metabolism for the same voxels, thus leading to higher sensitivity and specificity in tumor diagnosis. 112 …”

Section: With Positron Emission Tomographymentioning

confidence: 99%

“…Konecky et al 112 compare optical breast images with breast-only and whole-body PET. Their registration is complicated by the fact that the breast is freely hanging in the breast PET scanner, while a mild compression is applied in their optical breast imaging scanner.…”

Section: Registrationmentioning

confidence: 99%

Mono- and multimodal registration of optical breast images

et al. 2012

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Abstract. Optical breast imaging offers the possibility of noninvasive, low cost, and high sensitivity imaging of breast cancers. Poor spatial resolution and a lack of anatomical landmarks in optical images of the breast make interpretation difficult and motivate registration and fusion of these data with subsequent optical images and other breast imaging modalities. Methods used for registration and fusion of optical breast images are reviewed. Imaging concerns relevant to the registration problem are first highlighted, followed by a focus on both monomodal and multimodal registration of optical breast imaging. Where relevant, methods pertaining to other imaging modalities or imaged anatomies are presented. The multimodal registration discussion concerns digital x-ray mammography, ultrasound, magnetic resonance imaging, and positron emission tomography.

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Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography

Cited by 33 publications

References 55 publications

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

Optical mammography: Diffuse optical imaging of breast cancer

Mono- and multimodal registration of optical breast images

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