Comparison of differential renal function using technetium-99m mercaptoacetyltriglycine (MAG3) and technetium-99m dimercaptosuccinic acid (DMSA) renography in a paediatric population

Abstract

If a 99mTc-MAG3 study has been performed then a 99mTc-DMSA study is unnecessary provided DRF is normal on the 99mTc-MAG3 study and there is no scarring. A change in practice would lead to considerable savings in time, cost and radiation burden.

Evaluating the Efficacy of Bone Tracer 99mTC-MDP in Detecting Individual Renal Function Compared to Renal Cortical Imaging Agent 99mTC-DMSA

“…99m Tcdimercaptosuccinicacid ( 99m Tc-DMSA) is an agent that is actively taken up by the proximal and distal renal tubular cells, directly from per tubular vessels, not secreted to the tubular lumen [26] and accumulates in the renal cortex [27]. This modality is primarily used for imaging functioning cortical mass and individual renal function [28] since the abnormal kidney function was set at <45% for one kidney [29]. It is the most reliable method for assessing chronic cortical scarring [19].…”

Impact of magnetic resonance urography and ultrasonography on diagnosis and management of hydronephrosis and megaureter in paediatric patients

“…(3/3) ----PPV 90% 100% ----NPV 0% 75% ----Accuracy 90% 97% -- In addition to morphologic data, MRU can provide detailed information about differential renal function and drainage as measured by MAG3 renography. [6,23,24] Avoiding exposure to ionizing radiation it might have the potential to replace MAG3 renography as gold standard investigation of patients suspected for ureter obstruction. [25] In our retrospective study the temporal resolution of the dynamic MRU sequence was not suited for a functional analysis.…”

The Relative Function of Damaged Kidneys in Children Does Not Deteriorate Further at 3-Year Follow-up

“…Four studies were obtained using 99m Tc-MAG3 and included in the analysis, given that no clinically significant difference has been found between the 2 methods for calculating RRF. 10,11 Depth correction was applied to compensate for differences in renal depth. This is performed routinely in our department.…”