Comparison of Differential Agglutination Titre (D.A.T.) in Juvenile and Adult Rheumatoid Arthritis

In a prospective study of 110 children with juvenile rheumatoid arthritis, the incidence of rheumatoid factor was shown to be clearly related to age at onset. Only 3.8 per cent of children with onset before 4 years of age had positive tests by the latex fixation method, compared to 25.6 per cent with onset from 4 to 12 years of age and 77.8 per cent with onset between 12 and 16 years of age. These differences were confirmed by the SSC method, and the differences were statistically highly significant.

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Serum IgG and IgM Rheumatoid Factors by Solid Phase Radioimmunoassay

Wernick

LoSpalluto

Fink

et al. 1981

Arthritis & Rheumatism

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In this report, solid phase radioimmunoassays that specifically measure IgG rheumatoid factor (RF) and IgM RF in absolute concentrations are described. Polyclonal RF preparations were utilized as standards, and as little as 40 ng/ml of IgG RF and 1 ng/ml of IgM RF were detected. The IgG RF concentration of 26 seropositive rheumatoid sera was 439 ± 755 μg/ml (mean ± 1 SD), a level 107 times that of normal controls (P < 0.001). In contrast, levels for 49 children with juvenile rheumatoid arthritis (JRA) were 6.1 ± 3.7 μg/ ml for those with a polyarticular onset (JRA‐Po), 27.3 ± 113 μg/ml for the pauciarticular group (JRA‐Pa), and 12.6 ± 20.7 μg/ml for the group with a systemic onset (JRA‐S). None of these values differed significantly from the value of 6.0 ± 3.9 μg/ml measured in a juvenile control group. The IgM RF level in adult rheumatoid arthritis (RA) of 175 ± 221 μg/ml was also significantly elevated compared to controls (P < 0.001). In JRA, however, mean levels of 1.4 ± 2.0 μg/ml (JRA‐Po), 2.8 ± 8.3 μg/ml (JRA‐Pa), and 1.1 ± 0.7 μg/ml (JRA‐S) were not elevated significantly above the value of 1.2 μ 1.2 μg/ml measured in the juvenile control group. Hidden IgM RF was not found in 9 JRA sera tested. These marked differences in RF levels provide another indication that adult RA and JRA are distinct diseases.

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Comparison of Differential Agglutination Titre (D.A.T.) in Juvenile and Adult Rheumatoid Arthritis

Cited by 18 publications

References 6 publications

A five year prospective study of rheumatoid factor tests in juvenile rheumatoid arthritis

A five year prospective study of rheumatoid factor tests in juvenile rheumatoid arthritis

The relationship of rheumatoid factor to age of onset in Juvenile rheumatoid arthritis

Serum IgG and IgM Rheumatoid Factors by Solid Phase Radioimmunoassay

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