Comparison of different treatment schemes in 5-ALA interstitial photodynamic therapy for high-grade glioma in a preclinical model: An MRI study

Abstract

This article contains studies performed using animals. All applicable institutional and national guidelines for the care and use of animals were followed. The experimental design was declared to the French National Ethics Committee under reference number 04870.01. Authorship: M. Vermandel designed the study, cosupervised the study and wrote the manuscript; M. Quidet performed some of the experiments and helped write the manuscript; AS. Vignion-Dewalle performed the statistical analysis and helped write the manuscript; HA Leroy performed some of the experiments and read/corrected the manuscript; B. Leroux performed some of the experiments and reported results; and S. Mordon and N. Reyns cosupervised the study, designed the study and read/corrected the manuscript.

A Warp-Knitted Light-Emitting Fabric-Based Device for In Vitro Photodynamic Therapy: Description, Characterization, and Application on Human Cancer Cell Lines

“…Another approach to preventing oxygen depletion involves "on-off" light treatment, as oxygen reperfusion is promoted in tumor tissues during light-free periods [33,47]. However, in addition to addressing oxygen limitations, low-irradiance PDT appears to support progressive PS activation.…”

“…The use of lower levels of irradiance prevents the limitation of the photochemical reaction by an early complete consumption of oxygen and supports limited toxicity without reducing the cure rates [30][31][32]. PDT at lower irradiance levels, therefore, emerges as a way to deliver treatment with improved tolerability and an equal efficacy both for preclinical studies [33,34], and the management of patients [23,35]. Going a step further by reducing the dose of light results in similar effects to a conventional dose [7,10,34], but also allows using more compact light sources [31,36,37], and reduced treatment durations.…”

Recent advances in innovative strategies for enhanced cancer photodynamic therapy

“…For this purpose, Ismael et al 149 adopted cylindrical diffuse optical fibers (CDFs) as the light source (630-760 nm) and optimized the output CDFs power to specify the light dose (20-50) J·cm -2 to the tumor site, thus achieving the effective treatment of breast cancer. Recently, Vermandel et al 150 applied magnetic resonance imaging (MRI) as an estimator to assess the lesional effect of low-power 5-aminolevulinic acid (5-ALA)-based I-PDT. Based on the observations of MRI data and consideration of therapeutic effects, the 5-fraction light delivered at 5 mW during I-PDT is the most efficient treatment scheme with limited toxicity to adjacent healthy brain tissues, and might be a good way to comprehensively explore cell death pathways based on I-PDT.…”

The role of medical imaging in the context of photodynamic therapy

“…Based on these results, we performed a meta-analysis to investigate the link between molecular (histology) and functional imaging (MRI) [27]. We evaluated the impact of different PDT treatment schemes on Forty-eight "nude" rats grated with brain cancers cells.…”