Comparison of different methods of heart rate entropy analysis during acute anoxia superimposed on a chronic rat model of pulmonary hypertension

Gonçalves, Hernâni; Henriques‐Coelho, Tiago; Rocha, Ana Paula; Lourenço, André P.; Leite‐Moreira, Adelino F.; Bernardes, João

doi:10.1016/j.medengphy.2012.06.020

Cited by 5 publications

(4 citation statements)

References 45 publications

(82 reference statements)

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“…Cutoff frequencies divided the power spectrum into two main parts, LF – low frequency (0.04–1.0 Hz) and HF – high frequency (1.0–3.0 Hz), as previously described [12, 13]. …”

Section: Methodsmentioning

confidence: 99%

Altered sympathovagal balance and pain hypersensitivity in TNBS-induced colitis

Ciesielczyk

Furgała

Dobrek

et al. 2017

aoms

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IntroductionPain hypersensitivity, abnormal motility and autonomic dysfunction contribute to functional symptoms of inflammatory bowel disease (IBD).Material and methodsThe aim of this study was to assess: nociceptive thresholds for mechanical allodynia (MA) and thermal hyperalgesia (TH), intestinal motility (distal colonic transit and emptying), and cardiac autonomic neuropathy (indices of heart rate variability – HRV) in male Wistar rats with experimental trinitrobenzene sulfonic acid (TNBS) induced colitis. To identify a potential vagal contribution the bilateral subdiaphragmatic vagotomy (SDV) was performed.ResultsExperimental colitis resulted in a significant decrease in pain threshold (MA 23.60 ±2.12, p < 0.001, TH 8.51 ±1.49, p < 0.001), reduced expulsion time (6.2 ±3.5, p < 0,01) and increase in the sympathetic autonomic activity (LFnu 32.54 ±21.16, p < 0.03). The animals with diminished vagal integrity presented with reduced gastrointestinal motility (39.8 ±25.1, p < 0.01) and a decrease in the parasympathetic high-frequency domain of HRV (HFnu 55.37 ±22.80, p < 0.002). The vagotomized rats with colitis showed the strongest nociceptive response (MA 22.46 ±3.02, p < 0.004; TH 7.99 ±1.12, p < 0.003) as well as significant changes in sympatho-vagal balance on HRV testing (LFnu 28.25 ±14.66, p < 0.04; HFnu 71.34 ±14.55, p < 0.04).ConclusionsThe relationship between the cardiovascular and gastrointestinal system is modulated by neural, hormonal and inflammatory factors. This leads to dysregulation of the brain-gut interactions in the course of IBD. Sensitization and visceral-somatic convergence trigger pain hypersensitivity and autonomic sympathovagal imbalance. While integral vagal innervation impacts analgesic mechanisms via modulation of the immune response, SDV raises sympathetic activity and induces excessive hyperalgesia.

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“…Cutoff frequencies divided the power spectrum into two main parts, LF – low frequency (0.04–1.0 Hz) and HF – high frequency (1.0–3.0 Hz), as previously described [12, 13]. …”

Section: Methodsmentioning

confidence: 99%

Altered sympathovagal balance and pain hypersensitivity in TNBS-induced colitis

Ciesielczyk

Furgała

Dobrek

et al. 2017

aoms

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“…These findings suggest that the mother also increases the activity of her autonomous nervous system and decreases the activity of more complex heart rate control systems, but contrary to the fetus, also increases in sympatho-vagal balance were observed with the progression of labor except in acidemic cases. The results associated with the progression of labor are not surprising, as they represent responses to stress that have been previously described in laboratory and human studies [11][12][13], characterized by an increase followed by a decrease in sympatho-vagal imbalance. Those associated with fetal acidemia may denote a moderate response to stress on the maternal side, while the fetus has a more marked reaction associated with lower pO 2 values and higher hemodynamic instability.…”

Section: Discussionmentioning

confidence: 53%

Toward the improvement in fetal monitoring during labor with the inclusion of maternal heart rate analysis

Gonçalves

Pinto

Silva

et al. 2015

Med Biol Eng Comput

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Fetal heart rate (FHR) monitoring is used routinely in labor, but conventional methods have a limited capacity to detect fetal hypoxia/acidosis. An exploratory study was performed on the simultaneous assessment of maternal heart rate (MHR) and FHR variability, to evaluate their evolution during labor and their capacity to detect newborn acidemia. MHR and FHR were simultaneously recorded in 51 singleton term pregnancies during the last two hours of labor and compared with newborn umbilical artery blood (UAB) pH. Linear/nonlinear indices were computed separately for MHR and FHR. Interaction between MHR and FHR was quantified through the same indices on FHR-MHR and through their correlation and cross-entropy. Univariate and bivariate statistical analysis included nonparametric confidence intervals and statistical tests, receiver operating characteristic curves and linear discriminant analysis. Progression of labor was associated with a significant increase in most MHR and FHR linear indices, whereas entropy indices decreased. FHR alone and in combination with MHR as FHR-MHR evidenced the highest auROC values for prediction of fetal acidemia, with 0.76 and 0.88 for the UAB pH thresholds 7.20 and 7.15, respectively. The inclusion of MHR on bivariate analysis achieved sensitivity and specificity values of nearly 100 and 89.1%, respectively. These results suggest that simultaneous analysis of MHR and FHR may improve the identification of fetal acidemia compared with FHR alone, namely during the last hour of labor.

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“…Nevertheless, the fitting equations provided in Figure 6 can be used for the choice of the optimal fuzzy exponents in the dataset evaluated here. The measure stationarity is a possible issue concerning long-term time-series as previously pointed out [ 27 ]. However, all time-series and analyzed segments are supposed to be taken at baseline physiological state.…”

Section: Discussionmentioning

confidence: 99%

Multiscale Entropy Analysis of Short Signals: The Robustness of Fuzzy Entropy-Based Variants Compared to Full-Length Long Signals

Borin

Humeau-Heurtier

Silva

et al. 2021

Entropy

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Multiscale entropy (MSE) analysis is a fundamental approach to access the complexity of a time series by estimating its information creation over a range of temporal scales. However, MSE may not be accurate or valid for short time series. This is why previous studies applied different kinds of algorithm derivations to short-term time series. However, no study has systematically analyzed and compared their reliabilities. This study compares the MSE algorithm variations adapted to short time series on both human and rat heart rate variability (HRV) time series using long-term MSE as reference. The most used variations of MSE are studied: composite MSE (CMSE), refined composite MSE (RCMSE), modified MSE (MMSE), and their fuzzy versions. We also analyze the errors in MSE estimations for a range of incorporated fuzzy exponents. The results show that fuzzy MSE versions—as a function of time series length—present minimal errors compared to the non-fuzzy algorithms. The traditional multiscale entropy algorithm with fuzzy counting (MFE) has similar accuracy to alternative algorithms with better computing performance. For the best accuracy, the findings suggest different fuzzy exponents according to the time series length.

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Comparison of different methods of heart rate entropy analysis during acute anoxia superimposed on a chronic rat model of pulmonary hypertension

Cited by 5 publications

References 45 publications

Altered sympathovagal balance and pain hypersensitivity in TNBS-induced colitis

Altered sympathovagal balance and pain hypersensitivity in TNBS-induced colitis

Toward the improvement in fetal monitoring during labor with the inclusion of maternal heart rate analysis

Multiscale Entropy Analysis of Short Signals: The Robustness of Fuzzy Entropy-Based Variants Compared to Full-Length Long Signals

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