Comparison of different methodological approaches to identify risk factors of nosocomial infection in intensive care units

Abstract

The Cox regression analysis with quantitative time-dependent variables is the most valid alternative for assessing the risk of nosocomial infection per day of exposure to an extrinsic risk factor in the ICU.

Nosocomial infections in a Dutch neonatal intensive care unit: surveillance study with definitions for infection specifically adapted for neonates

“…If this ratio is unfavourable, it has been shown in several studies that adherence to infection control measures is reduced. [46][47][48][49] During our surveillance, there were periods when the patient-nurse ratio was suboptimal.…”

Impact of a prevention strategy targeting hand hygiene and catheter care on the incidence of catheter-related bloodstream infections*

“…Categorical variables were compared using the chi-square test; continuous variables were summarized as means or medians and compared using Wilcoxon's rank sum test. We used the Cox hazard proportional model to investigate the association between the study period and the risk of developing a CRBSI (28). We modeled time-to-event in a single event analysis in which the unit of analysis was the catheter.…”

Effect of severe thrombocytopenia on patient outcome after liver transplantation

“…Respiratory dysfunction (presence of one or more of the following): [15]. A backward procedure allowed for sequentially selecting the variables that were significantly related to severe thrombocytopenia or bleeding, as tested by the likelihood ratio test at the 5% level.…”