Comparison of Diastolic Septal Perforator Flow Velocities in Hypertrophic Cardiomyopathy Versus Hypertensive Left Ventricular Hypertrophy

Sherrrid, Mark V.; Mahenthiran, Jo; Casteneda, Vilma; Fincke, Rupert; Gasser, M.; Barač, Ivan; Thayaparan, Rose; Chaudhry, Farooq A.

doi:10.1016/j.amjcard.2005.07.128

Cited by 12 publications

(9 citation statements)

References 29 publications

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“…Conversely, β, which represents blood exchange velocity, was higher in patients with HCM at rest and during hyperaemia. The higher myocardial blood velocities in HCM is in agreement with previous findings in HCM32 33 and hypertensive heart disease 34. Moreover, the blunted hyperaemic response in patients with HCM was mainly due to increase of exchange frequency β and minimally due to increase of the rBV (mean increase of β 2.6-fold, rBV 1.1-fold).…”

Section: Discussionsupporting

confidence: 91%

Assessment of intravascular and extravascular mechanisms of myocardial perfusion abnormalities in obstructive hypertrophic cardiomyopathy by myocardial contrast echocardiography

Soliman

Knaapen

Geleijnse

et al. 2007

Heart

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Section: Discussionsupporting

confidence: 91%

Assessment of intravascular and extravascular mechanisms of myocardial perfusion abnormalities in obstructive hypertrophic cardiomyopathy by myocardial contrast echocardiography

Soliman

Knaapen

Geleijnse

et al. 2007

Heart

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“…More recently, Sherrid et al [76] showed no clear relationship between intramyocardial BFV and septal thickness, but they found positive correlation with LV mass. We recently found that high intramural peak diastolic velocity (up to 170 cm/s!)…”

Section: B) Diastolic Velocity In Intramural Arteriolesmentioning

confidence: 95%

“…In this latter compartment, however, it is more difficult to quantify the velocity, because of the 'shifting-spreading' jet caused by myocardial systolic contraction, which push the blood pool away, very quickly [70][71][72][73][74][75][76].…”

Section: C) Systolic Flow Velocitymentioning

confidence: 98%

“…The direction of blood flow depends on the course of these small vessels within the myocardial wall, but in general it goes from epicardial to endocardial layers. Peak diastolic velocity was reported to be from 30 to 60 cm/s in controls [19,62,64,[69][70][71][72][73][74][75][76].…”

Section: B) Diastolic Velocity In Intramural Arteriolesmentioning

confidence: 99%

“…Notwithstanding some optimistic data, no clear relationship was established between peak/mean diastolic BFV, either in the LAD or perforators, and extent of hypertrophy, LV mass, interstitial fibrosis, dynamic obstruction and/or systolic wall stress [69][70][71][72][73][74][75][76].…”

Section: B) Diastolic Velocity In Intramural Arteriolesmentioning

confidence: 99%

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Refined Echocardiographic Assessment and Contemporary Medical Treatment of Obstructive Hypertrophic Cardiomyopathy

Gregorio¹

2007

CHDDT

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Hypertrophic cardiomyopathy (HCM) is a complex cardiac disease, relatively common among genetic disorders. The prevalence is about 1:500 in the general population. Obstructive type occurs in about 25% of the cases. The clinical course is heterogeneous due to the large variety of genetic-based phenotypes with different prognostic impact. Primary HCM is one of the most important causes of sudden death in young people and may be a medical problem in athletes with physiologic left ventricular hypertrophy. In the last decade, however, several studies reported normal longevity. Echocardiography has emerged as the most important noninvasive method to make diagnosis and provide classifications of the disease. In this commentary, some out of the most recent and sophisticated applications of this method in HCM are reported. The most common pathophysiologic aspects and a proposal of classification of the obstruction-causing mechanisms, like systolic anterior motion of the mitral valve, papillary hypertrophy and dislocation, chordal slack, mid-cavity obliteration, are described. Some recent studies on coronary blood flow velocity and coronary reserve, performed by sophisticated Doppler echocardiography, have demonstrated important pathophysiological insights on microcirculatory impairment in patients with HCM. At present, advanced echocardiography surely improves the clinical management of these patients, and contributes to optimize the therapeutic strategies. However, the most appropriate framework of tests to be performed in the majority of them still remains a challenging clinical matter.

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Pathophysiological and clinical implications of high intramural coronary blood flow velocity in aortic stenosis

et al. 2019

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Comparison of Diastolic Septal Perforator Flow Velocities in Hypertrophic Cardiomyopathy Versus Hypertensive Left Ventricular Hypertrophy

Cited by 12 publications

References 29 publications

Assessment of intravascular and extravascular mechanisms of myocardial perfusion abnormalities in obstructive hypertrophic cardiomyopathy by myocardial contrast echocardiography

Assessment of intravascular and extravascular mechanisms of myocardial perfusion abnormalities in obstructive hypertrophic cardiomyopathy by myocardial contrast echocardiography

Refined Echocardiographic Assessment and Contemporary Medical Treatment of Obstructive Hypertrophic Cardiomyopathy

Pathophysiological and clinical implications of high intramural coronary blood flow velocity in aortic stenosis

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