Comparison of diagnostic values between CA125 combined with CA199 and ultrasound combined with CT in ovarian cancer

Abstract

Application values of CA125 combined with CA199 and ultrasound combined with computed tomography (CT) in the clinical diagnosis of ovarian cancer were compared. A retrospective analysis was performed on 168 ovarian cancer patients admitted to the Department of Gynecology in Jining No.1 People's Hospital from July 2013 to March 2016. Of the patients 107 with malignant tumors were in the malignant group, and 61 patients with benign tumors were in the benign group. Another 98 healthy controls in the same period were in the normal group. Chemiluminescence was used for the detection of levels of tumor markers CA125 and CA199 in the serum of all patients. CA125 combined with CA199 and color Doppler ultrasound combined with CT scan were used to diagnose and analyze the sensitivity, specificity, accuracy, and positive detection rate of ovarian cancer patients at different stages. The sensitivity, specificity and diagnostic coincidence rate of ultrasound combined with CT in the diagnosis of ovarian cancer were 97.20, 80.32 and 91.07%, respectively, which were significantly higher than the 92.52, 73.77 and 85.71% of serum CA125 combined with CA199. The positive detection rate of ultrasound combined with CT in the early diagnosis of ovarian cancer was 93.55%, higher than 83.87% of CA125 combined with CA199. The sensitivity, specificity, coincidence rate and positive detection rate of ultrasound combined with CT in the diagnosis were higher than those of CA125 combined with CA199. In the actual diagnosis process, these two diagnostic schemes can be selectively and comprehensively applied, so as to make a correct diagnosis, which is of great significance for reducing patient mortality.

Evaluation of Ovarian Tumors with Multidetector Computed Tomography and Tumor Markers: Differentiation of Stage I Serous Borderline Tumors and Stage I Serous Malignant Tumors Presenting as Solid-Cystic Mass

“…However, due to the overlapping features of SMOTs and SBOTs, a definitive diagnosis should not be made based on imaging alone or single tumor biomarkers. Several studies depending on imaging combined with tumor markers and multi-biomarker methods have been applied to increase the sensitivity and specificity of diagnosing early-stage ovarian cancer [ 14 , 19 , 30 ]. Guo et al [ 18 ] reported that the combination of CA125, CA19-9, and CEA markers was a promising method for detecting epithelial ovarian cancer.…”

Computer Tomography in the Diagnosis of Ovarian Cysts: The Role of Fluid Attenuation Values

“…In the same scenario, the diagnostic rates increase with contrast administration, up to 81% (CI, 77–84%) sensitivity and 98% (CI, 97–99%) specificity [ 24 ]. Other reports show different sensitivity rates, such as the study conducted by Guo [ 25 ], which showed that CT had a sensitivity of 83.18% and a specificity of 85.25% in 168 patients. Altogether, our results, although showing medium-high diagnostic power for detecting malignant tumors, cannot outperform the classic CT evaluation of these lesions.…”

Aberrant expression of ADAM9 in ovarian cancer and its clinical significance

“…The early diagnosis of OC is of great importance to increase the survival of the patients. [19][20][21] It is still unclear whether ADAM9 can serve as potential diagnostic biomarker for OC. In this study, we further explored the potential diagnostic value of ADAM9 using fresh OC tissues.…”

“…The early diagnosis of OC is of great importance to increase the survival of the patients . It is still unclear whether ADAM9 can serve as potential diagnostic biomarker for OC.…”