Comparison of Diagnostic Sensitivity and Quantitative Indices Between 68Ga-DOTATOC PET/CT and 111In-Pentetreotide SPECT/CT in Neuroendocrine Tumors: a Preliminary Report

Lee, Inki; Paeng, Jin Chul; Lee, Soo Jin; Shin, Chan Soo; Jang, Jin Young; Cheon, Gi Jeong; Lee, Dong Hoon; Chung, June Key; Kang, Keon Wook

doi:10.1007/s13139-015-0356-y

Cited by 31 publications

(28 citation statements)

References 25 publications

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“…Therefore, the affinity of these tracers for DAT is identical (Seo et al, ). When compared with SPECT, PET has higher spatial resolution and higher sensitivity to signal, which produces better image quality for analysis (Lee et al, ). The SBR on SPECT may be underestimated because of the method of attenuation correction.…”

Section: Discussionmentioning

confidence: 99%

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Lee

Kim

Park

et al. 2018

Synapse

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I-FP-CIT and F-FP-CIT are radiotracers which are widely used to diagnose Parkinson's disease (PD). However, to our knowledge, no studies to date have made head-to-head comparisons between I-FP-CIT and F-FP-CIT. Therefore, in this study, I-FP-CIT SPECT/CT was compared with F-FP-CIT PET/CT in the same cohort of subjects. Patients with PD and essential tremor (ET) underwent I-FP-CIT SPECT/CT and F-FP-CIT PET/CT. Visual and semiquantitative analyses were conducted. The specific binding ratio (SBR) and putamen to caudate ratio (PCR) were compared between subjects who underwent I-FP-CIT SPECT/CT and F-FP-CIT PET/CT. Visual analysis showed that the striatal uptake of both radiotracers was decreased in the PD group, whereas striatal uptake was intact in the ET group. The SBR between I-FP-CIT SPECT/CT and F-FP-CIT PET/CT showed a positive correlation (r = .78, p< .01). However, the mean SBRs on F-FP-CIT PET/CT were higher than those on I-FP-CIT SPECT/CT (2.19 ± .87 and 1.22 ± .49, respectively; p < .01). The PCRs in these two modalities were correlated with each other (r = .71, p < .01). The mean PCRs on F-FP-CIT PET/CT were not significantly higher than those on I-FP-CIT SPECT/CT (1.31 ± .19 and 0.98 ± .06, respectively; p = .06). These preliminary results indicate that the uptake of both I-FP-CIT and F-FP-CIT was decreased in the PD group when compared with the ET controls. Visual analyses using both methods did not affect the diagnostic accuracy in this study. However, semiquantitative analysis indicated a better contrast of F-FP-CIT PET/CT relative to I-FP-CIT SPECT/CT.

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Section: Discussionmentioning

confidence: 99%

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Lee

Kim

Park

et al. 2018

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“…In Poland, 111 In-labelled somatostatin analogues are no longer used in the diagnostics of NENs. In clinical practice, commonly used are 99m Tc-labelled agonists of somatostatin receptors: 99mTc-HYNIC-TATE and 99m Tc-EDDA/HYNIC-TOC, both characterised by a similar sensitivity in the imaging of NENs [51].…”

Section: Diagnostic Imagingmentioning

confidence: 99%

“…The sensitivity of SRI depends on the method (it is the highest in PET/CT examination). For most types of GEP NET and locations the SRI sensitivity images between 54 and 100% [107][108][109][110][111][112][113][114][115]. Insulinoma is an exception, as somatostatin receptor overexpression is found in 50-60% of cases [116].…”

Section: Radioisotope-labelled Somatostatin Analogues Imagingmentioning

confidence: 99%

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Zalecenia ogólne dotyczące postępowania diagnostyczno-terapeutycznego w nowotworach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

Kos–Kudła

Blicharz-Dorniak²,

Strzelczyk³

et al. 2017

Endokrynologia Polska

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Progress in the diagnostics and therapy of gastro-entero-pancreatic (GEP) neuroendocrine neoplasms (NEN), the published results of new randomised clinical trials, and the new guidelines issued by the European Neuroendocrine Tumour Society (ENETS) have led the Polish Network of Neuroendocrine Tumours to update the 2013 guidelines regarding management of these neoplasms. We present the general recommendations for the management of NENs, developed by experts during the Third Round Table Conference - Diagnostics and therapy of gastro-entero-pancreatic neuroendocrine neoplasms: Polish recommendations in view of current European recommenda-tions, which took place in December 2016 in Żelechów near Warsaw. Drawing from the extensive experience of centres dealing with this type of neoplasms, we hope that we have managed to develop the optimal management system, applying the most recent achievements in the field of medicine, for these patients, and that it can be implemented effectively in Poland. These management guidelines have been arranged in the following order: gastric and duodenal NENs (including gastrinoma); pancreatic NENs; NENs of the small intestine and appendix, and colorectal NENs.

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“…Neuroendocrine tumor scan was performed in a small number of cases of neuroendocrine tumors in 2013 in Korea: 314 MIBG SPECT cases (154 cases in combination with SPECT/CT) and 33 octreotide SPECT cases (13 cases in combination with SPECT/CT) [2]. Recent studies reported that PET/CT using Ga-DOTA peptide has better diagnostic accuracy than octreotide scintigraphy in patients with neuroendocrine tumors [27,28]. However, since Ga-DOTA peptide is not extensively used in Korea, SPECT and SPECT/CT using somatostatin receptors are still valuable imaging methods for the diagnosis and treatment of neuroendocrine tumors.…”

Section: Neuroendocrine Tumormentioning

confidence: 99%

The Current Status of SPECT or SPECT/CT in South Korea

Yoo

Choi

Chung

2016

Nucl Med Mol Imaging

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The first step to nuclear medicine in Korea started with introduction of the gamma camera in 1969. Although planar images with the gamma camera give important functional information, they have the limitations that result from 2-dimensional images. Single-photon emission computed tomography (SPECT) due to its 3-dimensional image acquisition is superior to earlier planar gamma imaging in image resolution and diagnostic accuracy. As demand for a hybrid functional and anatomical imaging device has increased, integrated SPECT/CT systems have been used. In Korea, SPECT/CT was for the first time installed in 2003. SPECT/CT can eliminate many possible pitfalls on SPECT-alone images, making better attenuation correction and thereby improving image quality. Therefore, SPECT/CT is clinically preferred in many hospitals in various aspects. More recently, additional SPECT/CT images taken from the region with equivocal uptake on planar images have been helpful in making precise interpretation as part of their clinical workup in postoperative thyroid cancer patients. SPECT and SPECT/CT have various advantages, but its clinical application has gradually decreased in recent few years. While some researchers investigated the myocardial blood flow with cardiac PET using F-18 FDG or N-13 ammonia, myocardial perfusion SPECT is, at present, the radionuclide imaging study of choice for the risk stratification and guiding therapy in the coronary artery disease patients in Korea. New diagnostic radiopharmaceuticals for AD have received increasing attention; nevertheless, brain SPECT will remain the most reliable modality evaluating cerebral perfusion.

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Comparison of Diagnostic Sensitivity and Quantitative Indices Between 68Ga-DOTATOC PET/CT and 111In-Pentetreotide SPECT/CT in Neuroendocrine Tumors: a Preliminary Report

Cited by 31 publications

References 25 publications

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Zalecenia ogólne dotyczące postępowania diagnostyczno-terapeutycznego w nowotworach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

The Current Status of SPECT or SPECT/CT in South Korea

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Comparison of Diagnostic Sensitivity and Quantitative Indices Between 68Ga-DOTATOC PET/CT and 111In-Pentetreotide SPECT/CT in Neuroendocrine Tumors: a Preliminary Report

Cited by 31 publications

References 25 publications

Head‐to‐head comparison of 18F‐FP‐CIT and 123I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Head‐to‐head comparison of 18F‐FP‐CIT and 123I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Zalecenia ogólne dotyczące postępowania diagnostyczno-terapeutycznego w nowotworach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

The Current Status of SPECT or SPECT/CT in South Korea

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Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

Head‐to‐head comparison of ¹⁸F‐FP‐CIT and ¹²³I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study