Comparison of Diagnostic Criteria for Common Variable Immunodeficiency Disorders (CVID) in the New Zealand CVID Cohort Study

Ameratunga, Rohan; Longhurst, Hilary; Steele, Richard; Woon, See‐Tarn

doi:10.1007/s12016-021-08860-7

Cited by 12 publications

(8 citation statements)

References 45 publications

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“…A similar outcome was noted in the New Zealand CVID Study (NZCS) ( 48 , 49 ). Most patients meeting criteria for CVID had excellent responses to tetanus toxoid and HIB.…”

Section: Cvid As a Model Of Vaccine Challenge Responses In Immunocompromised Personssupporting

confidence: 76%

Common Variable Immunodeficiency Disorders as a Model for Assessing COVID-19 Vaccine Responses in Immunocompromised Patients

et al. 2022

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“…A similar outcome was noted in the New Zealand CVID Study (NZCS) ( 48 , 49 ). Most patients meeting criteria for CVID had excellent responses to tetanus toxoid and HIB.…”

Section: Cvid As a Model Of Vaccine Challenge Responses In Immunocompromised Personssupporting

confidence: 76%

Common Variable Immunodeficiency Disorders as a Model for Assessing COVID-19 Vaccine Responses in Immunocompromised Patients

et al. 2022

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“…9,10 Other researchers have compared those criteria and added guidelines for their proper interpretation. 13,23,24 In our settings, the ESID registry working definition for CVID is a powerful tool to characterize the hipogammaglobulinemic patients. 9 Most of the patients included here fulfilled the clinical criteria defined by ESID and also exhibited decreased serum IgG and IgA levels.…”

Section: Discussionmentioning

confidence: 99%

“…This was also problematic in other studies. 24 However, the international consensus for CVID diagnosis establishes that the repeated Ig measurement can be disregarded if either the IgG levels are below 100-300 mg/dL, depending on age, or if there are clinical considerations to start the Ig replacement as quickly as possible. 13 Currently, we performed the two required Ig measurements and a serum protein electrophoresis to confirm the hypogammaglobulinemia in the CVID suspicious patients who have no indication to speed up the replacement SCIG/IVIG therapy.…”

Section: Discussionmentioning

confidence: 99%

“…10 In New Zealand, vaccination with Haemophilus influenzae type B, Pneumovax ® as well as diphtheria and tetanus toxoids are required in patients with IgG>3 g/L. 24 However, this aspect is not specified in the registry working definition for CVID. 9 The international consensus document for CVID recommends the evaluation of one T-cell dependent and one T-cell independent antigen.…”

Section: Sources Of the Informationmentioning

confidence: 99%

“…10,25 All these difficulties to implement and evaluating responses to vaccination during CVID diagnosis are likely the reasons why Ameratunga excluded these studies from the main categories of criteria to consider a probable case of CVID. 10,24 Whether these alternative diagnosis criteria are logistically more suitable in low-resource settings like ours needs to be evaluated.…”

Section: Sources Of the Informationmentioning

confidence: 99%

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Application of the diagnostic criteria for Common Variable Immunodeficiency in resource-limited settings

Álvarez-Álvarez

Duque

Vásquez-Echeverri

et al. 2022

Allergol Immunopathol

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Introduction: Common variable immunodeficiency (CVID) is the most prevalent symptomatic humoral deficiency; however, its heterogeneous presentation makes the diagnosis difficult. The present study is aimed to verify the CVID diagnostic criteria as established by the European Society for Immunodeficiencies in 42 CVID patients from our outpatient clinic. Methods: Information was collected from their medical records and when needed, lymphocyte subpopulations in peripheral blood (PB) were performed by flow cytometry. Results: All the patients fulfilled the clinical working definition for CVID and showed decreased serum IgG and IgA at diagnosis. Over two-thirds of the patients had decreased memory B cell percentages. However, the remaining patients exhibited other quantitative B cell defects in PB. Evaluation of vaccination responses was only found in 13 records and 69% were not responsive. None of the patients were subjected to vaccination studies to both, T-cell dependent and independent antigens. The two required tests to evaluate T cell responses were performed in 84.2% of the patients and reported normal. Without the support of third-party payers, only 34.2% of our patients would have completed the required evaluations. Conclusions: Further efforts are needed to speed up CVID diagnosis in low-resourced settings, increasing the availability of the required resources and optimizing the healthcare supply chain.

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Limitations in the clinical utility of vaccine challenge responses in the evaluation of primary antibody deficiency including Common Variable Immunodeficiency Disorders

Ameratunga,

Longhurst,

Leung

et al. 2024

Clinical Immunology

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Comparison of Diagnostic Criteria for Common Variable Immunodeficiency Disorders (CVID) in the New Zealand CVID Cohort Study

Cited by 12 publications

References 45 publications

Common Variable Immunodeficiency Disorders as a Model for Assessing COVID-19 Vaccine Responses in Immunocompromised Patients

Common Variable Immunodeficiency Disorders as a Model for Assessing COVID-19 Vaccine Responses in Immunocompromised Patients

Application of the diagnostic criteria for Common Variable Immunodeficiency in resource-limited settings

Limitations in the clinical utility of vaccine challenge responses in the evaluation of primary antibody deficiency including Common Variable Immunodeficiency Disorders

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