Comparison of dexmedetomidine, remifentanil and esmolol in controlled hypotensive anaesthesia

Comparison of Esmolol to Nitroglycerine in Controlling Hypotension During Nasal Surgery

“…Degoute et al [8] reported that the target SAP (80 mmHg) in tympanoplasty procedures was achieved in 53.3±4.4 seconds with esmolol (210±33 μg/kg/min). Using esmolol at 50-300 μg/kg/min, Turan et al [9] demonstrated that MAP (>60 mmHg) was achieved in 13.35±8.4 min. Although in our study, the period in which the target SAP (80 mmHg) achieved was statistically similar, it was achieved in a shorter period of time in the esmolol group (Group E: 68.0±8.3 sec, Group N: 75.0±11.7 sec).…”

“…The use of vasodilators in CH has been reported to result in the possible development of tachyphylaxis and cyanide toxicity with SNP [3,5]. In recent years, the rapid onset and short half-life of esmolol, as well as easy titration and close blood pressure control, has resulted in its use for CH [6][7][8][9][10].…”

Dexmedetomidine Versus Nitroglycerine for Controlled Hypotension in Head & Neck Surgery: A Prospective Randomised Clinical Study

“…Some of the studies shown that dexmedetomidine decreases the bleeding in surgeries with minimal hemodynamic alteration. [6,8,9,12] Nitroglycerin is a nitric oxide releaser which causes peripheral vasodilation by selectively dilating the venous capacitance vessels with reduction in venous return to the heart resulting in systemic hypotension. But there may be reflex tachycardia partially mitigating the beneficial effects of hypotension.…”

“…[3,7] Dexmedetomidine an alpha 2 agonists has also gained wide acceptance for induced hypotension because of its sedative, analgesic and anxiolytic properties. [6,8,9] . Here we put forward a comparative study between intravenous Dexmedetomidine and Nitroglycerine for controlled hypotension in head & neck surgery.…”

Effectiveness of dexmedetomidine in reducing blood loss during middle ear surgery under general anaesthesia: a randomized controlled trial

“…The loading and maintenance dose of dexmedetomidine in this study is comparable to doses used in similar previous studies. 4,13,[22][23][24][25][26] Aho and colleagues 12 found that a dose of 0.3mcg/kg/hour as maintenance infusion on patients posted for gynaecological surgery was ineffective in attenuating HR and SBP. On the other hand, in another study, they observed that a higher dose of dexmedetomidine infusion in the range of 0.6mcg/kg/hour resulted in hemodynamic instability 17 .…”