Comparison of Detection of HPV DNA from Menstrual Blood in Menstrual Cup and Cervical Swab in Sexual Single Partner and Multi-Partner Women

Abstract

Introduction: Human Papillomavirus (HPV) is a virus found in the cervix of a sexually active woman. HPV enters micro lesions in the cervical epithelium binds to primary receptors in the membrane layer over time and becomes an invasive cancer. The invasive cancer process takes 5-10 years. Detection of HPV DNA has currently used cervical swab samples. Currently, HPV DNA can be detected in menstrual blood. Objective: this study aimed to analyze the comparison of HPV DNA from menstrual blood in menstrual cups and cervical swabs and to analyze the risk factors associated with positive HPV DNA in single-partner and multi-partner women.Method: cross-sectional method at one time with an analytical observational method using consecutive sampling, sample selection according to the researcher's criteria. The sample used was 44 women according to the inclusion and exclusion criteria. The Spearman statistical test was used to determine the comparison of results from detecting HPV DNA from menstrual blood and cervical swabs, determining the analysis of risk factors (age, occupation, parity, sexual partners, contraception, and smoking) related to positive HPV DNA in both groups using the chi-square test. and Spearman test according to the data scale. Results: there was no difference in results between HPV DNA from menstrual blood in menstrual cups and cervical swabs in both the single-partner and multi-sexual partner groups of women with p= 0,209 and 0,301. Conclusion: there is a comparison of HPV DNA detection from menstrual blood in menstrual cups and cervical swabs in single-partner and multi-sexual partner women. The accuracy of menstrual blood examination results is good in detecting HPV DNA