Comparison of depression between primary and secondary infertile couples

Yoldemir, Tevfik; Yassa, Mahmut; Atasayan, Kemal

doi:10.1080/09513590.2020.1807503

Cited by 12 publications

(13 citation statements)

References 21 publications

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“…Infertile patients often feel low self-esteem, mistrust, lack of self-confidence, insecurity, and lack of faith [25,26] with 25% to 60% reporting psychiatric symptoms and having higher depression levels than fertile couples [27]. Furthermore, depression tended to be more severe in patients with primary infertility than in those with secondary infertility [28]. Depression has a measurable impact on MI.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Underlying Mechanism of Depression on Male Infertility: A Bioinformatics and Experimental Research Study

Zhao

Yan

et al. 2023

Andrologia

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The impact of depression on spermatogenic function and protein expression was investigated by reference to a bioinformatics database for the prediction of key targets and pathways. Experimental validation was performed using a rat model established using the chronic restraint stress method. Organ coefficients and semen parameters were measured. Hematoxylin and eosin (HE) staining was performed to compare testicular tissue between model and control rats. Western blotting and RT–qPCR were conducted to evaluate protein and mRNA expression. As a result, depression and male infertility (MI) were found to share 81 common targets, and the PI3K/Akt/FOXO1 signaling pathway was involved in both conditions. Animal experiments showed testis and epididymis coefficients to be lower in the model group. HE staining showed damage to the seminiferous tubules of model rats. PI3K and p-Akt mRNA and protein were present at lower levels and FOXO1 at higher levels in the model group. Depression led to reduced spermatogenic function in rats and might be associated with differential expression of the PI3K/Akt/FOXO1 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Investigation of the Underlying Mechanism of Depression on Male Infertility: A Bioinformatics and Experimental Research Study

Zhao

Yan

et al. 2023

Andrologia

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“…The pain of miscarriage, and desire to prevent future miscarriages, may motivate some males to get a RU evaluation. There is data to show that both male and female depressive scores correlate with the number of prior infertility treatment cycles (Yoldemir et al, 2020 ), which may motivate some couples to have both partners evaluated. We also found that men with secondary infertility and a child with a different partner were more likely to drive a greater distance for RU consultation.…”

Section: Discussionmentioning

confidence: 99%

How far will they go? Distance and driving times that north American men travel to see a reproductive urologist

et al. 2022

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Male factor infertility affects about 50% of infertile couples. However, male factor infertility is largely under‐evaluated due to multiple reasons. This study is to determine the time men travel for fertility evaluation, and factors associated with driving longer. Data from the Andrology Research Consortium were analysed. Driving distance and time were calculated by comparing “patient postal code” with “clinic postal code”, then stratified into quartiles. Patients with the longest driving times (> 75th percentile [Q4]) were compared with those having shorter driving times. Logistic regression analysis was used to identify factors associated with longer driving times. Sixteen clinics and 3029 men were included. The median driving distance was 18.1 miles, median driving time was 32 min, and Q4 driving time was 49 min. Factors correlated with having Q4 driving time were age > 30 years, native Indian and Caucasian race, body mass index (BMI) > 30 kg/m2, history of miscarriage, children with previous partner, self‐referral, prior vasectomy, and prior marijuana use. On logistic regression, males aged < 30 years were more likely to be in Q4 for driving time versus older males. Blacks and Asians were less likely to travel further than Caucasians. Overweight/obese men, those having children with previous partner, and with prior vasectomy were more likely to be in Q4 travelling time. Factors correlated with longer driving times include younger age, native Indian and Caucasian race, higher BMI, children with prior partner, and prior vasectomy. These may reflect groups that drive long distances for reproductive care. The study provides an opportunity to better access these groups and minimise their barriers to fertility care.

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“…They also determined that women had increased feelings of hopelessness with increased severity of depressive symptoms. Yoldemir et al [24] compared the depression between primary and secondary infertile couples and found mild depression was higher in the primary infertile women. In authors' investigation, the prevalence of depression was lower compared to this study, which consisted of infertile women who were mainly housewives.…”

Section: Discussionmentioning

confidence: 99%

Level of depression and hopelessness among women with infertility during the outbreak of COVID-19: a cross-sectional investigation

2021

Clinical and Experimental Obstetrics & Gynecology

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Background: Novel coronavirus disease 2019 (COVID-19) outbreak negatively impacted on the mental wellbeing of infertile couples, because of the World Health Organization's recommendation to stop all fertility treatments. This study aims to investigate the level of depression and hopelessness during the COVID-19 outbreak, in women with primary and secondary infertility. Methods: A 16-item online questionnaire was applied to a total of 220 women with primary and secondary infertility in June 2020. Participants' knowledge and concerns about COVID-19 pandemic stop of treatments and follow-up preferences were evaluated. In addition, the Beck Depression Inventory (BDI) and the Beck Hopelessness Scale (BHS) were adapted to Turkish and applied to each participant. Total scores of inventories between women were calculated. The correlation between depression and hopelessness levels of the groups was evaluated. Results: The BDI and BHS mean scores of 220 infertile women who completed our questionnaire were 14.63 ± 9.123 and 5.43 ± 5.026 and Cronbach's α-values were 0.853 and 0.904, respectively. It was found that 142 women with secondary infertility had higher mean depression and hopelessness scores (15.92 ± 9.758, 11.81 ± 6.501; P = 0.001) VS 78 women with primary infertility (6.51 ± 5.262, 3.78 ± 3.670; P = 0.000). A strong positive correlation was detected between depression and hopelessness levels for each group (r = 0.625, P = 0.000 and r = 0.740, P = 0.000). Conclusions: Total depression and hopelessness scores of both groups were in a strong positive correlation with primary and secondary infertility during the COVID-19 outbreak. Particularly, women with secondary infertility had mild depression and low levels of hopelessness.

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Comparison of depression between primary and secondary infertile couples

Cited by 12 publications

References 21 publications

Investigation of the Underlying Mechanism of Depression on Male Infertility: A Bioinformatics and Experimental Research Study

Investigation of the Underlying Mechanism of Depression on Male Infertility: A Bioinformatics and Experimental Research Study

How far will they go? Distance and driving times that north American men travel to see a reproductive urologist

Level of depression and hopelessness among women with infertility during the outbreak of COVID-19: a cross-sectional investigation

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