Comparison of Del Nido and Intermittent Warm Blood Cardioplegia in Adult Coronary Artery Bypass Surgery: Randomized, Prospective, Single Center Trial

Abstract

Objectives:The purpose ofthis randomized prospective study was to investigate the efficacy and clinical results of del Nido solution (DNS) use in coronary artery bypass grafting (CABG) surgery compared to intermittent warm blood cardioplegia (IWBC). Methods:Thirty-nine adult patients who underwent primary isolated CABG surgery with cardiopulmonary bypass (CPB) between June 2018 and February 2019 were included in the study. DNS was used in 17 patients and IWBC in 22. The clinical and laboratory results were then compared. Results:Aortic cross-clamp time and CPB time were both lower with DNS. However, we observed no statistically significant difference in clinical results between the two methods, including postoperative myocardial enzymes. Conclusion:Single-dose DNS reduced CPB and aortic cross-clamp times, and provided similar short-term clinical and laboratory outcomes to a conventional multi-dose BC strategy in isolated CABG surgery.