2020
DOI: 10.1101/2020.05.26.20113845
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Comparison of Decision Modeling Approaches for Health Technology and Policy Evaluation

Abstract: We discuss tradeoffs and errors associated with approaches to modeling health economic decisions. Through an application in pharmacogenomic (PGx) testing to guide drug selection for individuals with a genetic variant, we assessed model accuracy, optimal decisions and computation time for an identical decision scenario modeled four ways: using (1) coupled-time differential equations [DEQ]; (2) a cohort-based discrete-time state transition model [MARKOV]; (3) an individual discrete-time state transition microsim… Show more

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Cited by 1 publication
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References 38 publications
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“…Both cohort models and microsimulation models involve a dynamic simulation of health and disease processes over time. Microsimulation models generally permit greater flexibility in the modelling of event timing and with respect to the interdependency of events [39]. In both types of model, each simulated individual sojourns for a period of time in different states of health, to which are attached state-specific costs and quality of life values.…”
Section: Study Selectionmentioning
confidence: 99%
“…Both cohort models and microsimulation models involve a dynamic simulation of health and disease processes over time. Microsimulation models generally permit greater flexibility in the modelling of event timing and with respect to the interdependency of events [39]. In both types of model, each simulated individual sojourns for a period of time in different states of health, to which are attached state-specific costs and quality of life values.…”
Section: Study Selectionmentioning
confidence: 99%