Comparison of dantrolene sodium and diazepam in the treatment of spasticity.

Schmidt, Regina; Lee, R H; Spehlmann, Rainer

doi:10.1136/jnnp.39.4.350

Cited by 55 publications

(39 citation statements)

References 20 publications

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“…Little weight can be put on the comparison with placebo, as it was single blind only, and reported only four patients with MS. With the exception of the study in which diazepam was compared with dantrolene, 25 in which patients and evaluators were not blind to drug dose level (although they were to drug), the other study designs appear to have been robust. A further criticism of that study is that there were multiple outcome measures, and multiple comparisons, which must have increased the chance of a Type I error.…”

Section: Validitymentioning

confidence: 99%

“…The severity of spasticity and extent of disability were variable. In one study, 25 patients were mainly ambulatory without severe lower extremity weakness. In another, 26 five of the 20 patients were confined to a wheelchair or bed, and one was completely paraplegic.…”

Section: Populations Examinedmentioning

confidence: 99%

“…28 Another used ad hoc scales of spasticity, strength, clonus and reflexes. 24 The other crossover study 25 used clinical and 'simple mechanical equipment' to assess 10 physical functions. As this was the study which evaluated high and low doses of both dantrolene and diazepam, and involved a control evaluation (drug free), a total of 90 separate comparisons were reported on, which must have increased the chance of a Type I error.…”

Section: Outcomes Measuredmentioning

confidence: 99%

“…The commonest reported side-effects were sedation and weakness. Four patients in each of two trials 25,41 had to withdraw from the study because of the side-effects. …”

mentioning

confidence: 99%

See 3 more Smart Citations

Treatments for spasticity and pain in multiple sclerosis: a systematic review

Beard

Hunn²,

Wight³

2003

Health Technol Assess

236

131

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Section: Validitymentioning

confidence: 99%

Section: Populations Examinedmentioning

confidence: 99%

Section: Outcomes Measuredmentioning

confidence: 99%

“…The commonest reported side-effects were sedation and weakness. Four patients in each of two trials 25,41 had to withdraw from the study because of the side-effects. …”

mentioning

confidence: 99%

See 2 more Smart Citations

Treatments for spasticity and pain in multiple sclerosis: a systematic review

Beard

Hunn²,

Wight³

2003

Health Technol Assess

236

131

View full text Add to dashboard Cite

show abstract

“…A later trial compared dantrolene versus diazepam using a fixed increasing dosage schedule over a two-week period, followed by another 2 weeks of maximum dose 43 .…”

Section: Dantrolenementioning

confidence: 99%