Comparison of cytotoxic and apoptosis-inducing effects of MTA, propolis, and propolis-MTA on immature dental pulp stem cells

Nazemi Salman, B.; Kalantari, M.; Mohebbi Rad, M.; Saburi, E.

doi:10.1007/s40368-023-00849-4

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Nevertheless, providing rats with propolis extract prior to antineoplastic agent injections shielded the heart and liver tissues from mitochondrial stress [ 221 ]. Studies have suggested that apoptosis stands out as the primary process by which propolis demonstrates its antitumor effects [ 152 , 222 , 223 , 224 ]. In the course of apoptosis, the mitochondrial membrane potential is compromised by the establishment of permeability transition pores.…”

Section: Mitochondriamentioning

confidence: 99%

Exploring the Prospective Role of Propolis in Modifying Aging Hallmarks

Scorza,

Goncalves,

Finsterer

et al. 2024

Cells

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Aging populations worldwide are placing age-related diseases at the forefront of the research agenda. The therapeutic potential of natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular and molecular-level changes associated with age-related diseases. With this in mind, scientists have introduced a contextual framework to guide future aging research, called the hallmarks of aging. This framework encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, and altered intercellular communication. Propolis, with its rich array of bioactive compounds, functions as a potent functional food, modulating metabolism, gut microbiota, inflammation, and immune response, offering significant health benefits. Studies emphasize propolis’ properties, such as antitumor, cardioprotective, and neuroprotective effects, as well as its ability to mitigate inflammation, oxidative stress, DNA damage, and pathogenic gut bacteria growth. This article underscores current scientific evidence supporting propolis’ role in controlling molecular and cellular characteristics linked to aging and its hallmarks, hypothesizing its potential in geroscience research. The aim is to discover novel therapeutic strategies to improve health and quality of life in older individuals, addressing existing deficits and perspectives in this research area.

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