Abstract:Bioconjugation of polymers to proteins is a method to
impart improved
stability and pharmacokinetic properties to biologic systems. However,
the precise effects of polymer architecture on the resulting bioconjugates
are not well understood. Particularly, cyclic polymers are known to
possess unique features such as a decreased hydrodynamic radius when
compared to their linear counterparts of the same molecular weight,
but have not yet been studied. Here, we report the first bioconjugation
of a cyclic polymer, p… Show more
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