Comparison of curcumin with intralesional steroid injections in Oral Submucous Fibrosis – A randomized, open-label interventional study

Yadav, Monu; Konidena, Aravinda; Saxena, Vasu Siddhartha; Srinivas, K; Ratnakar, P; Gupta, J P; Sachdev, Arti Saluja; Shivhare, Peeyush

doi:10.1016/j.jobcr.2014.11.003

Cited by 52 publications

(71 citation statements)

References 12 publications

(12 reference statements)

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“…Similar non significant improvement in tongue protrusion was observed in the study conducted by Monu yadav et al [6] on 40 OSMF patients. The authors stated that conventional method of intralesional steroids was better in improving tongue protrusion.…”

Section: World Journal Of Pharmaceutical Researchsupporting

confidence: 85%

“…Therefore the present study was conducted to evaluate the efficacy of systemic and topical application of curcumin in treating OSMF patients and results were obtained. Improvement of burning sensation was noted by many other authors like Monu Yadav et al [6] in his study on 40 OSMF patients concluded that curcumin is beneficial and effective in reducing burning sensation in OSMF patients as compared to the intra-lesional injections of corticosteroids and hyaluronidase. Rai B et al [7] in his study on 25 patients also stated that curcumin administration both topical and systemic lead to significant improvement in clinical symptoms (burning sensation) along with reduction in serum and salivary malondialdehyde levels.…”

Section: Discussionmentioning

confidence: 72%

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Curcumin as a Cure; Comparison of the Efficacy of Systemic and Topical Administration of Curcumin in Oral Submucous Fibrosis Patients: A Cross-Sectional Study

Nagarajappa¹

2017

WJPR

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Section: World Journal Of Pharmaceutical Researchsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 72%

Curcumin as a Cure; Comparison of the Efficacy of Systemic and Topical Administration of Curcumin in Oral Submucous Fibrosis Patients: A Cross-Sectional Study

Nagarajappa¹

2017

WJPR

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“…Yadav et al. have reported complete resolution of burning sensation only with a curcumin group compared with intralesional medications . Das et al.…”

Section: Discussionmentioning

confidence: 99%

“…A comprehensive review of the literature reveals only 10 research papers assessing the use of curcumin in OSMF patients . These include randomized control trials, observational studies and a pre‐post study design.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of curcumin and antioxidants in the management of oral submucous fibrosis

Rai

Kaur

Gombra

et al. 2019

J of Invest & Clin Dent

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Aim The present study aims to evaluate the efficacy and safety of curcumin in both topical and systemic forms for management of oral submucous fibrosis in comparison with the antioxidants. Methods In this randomized parallel‐group single‐center trial, 119 patients were enrolled. Group I received antioxidants, group II received curcumin in systemic form and group III received curcumin in both systemic and topical forms. The primary outcomes assessed were interincisal mouth opening and burning sensation using a visual analog scale. The secondary outcomes were tongue protrusion and adverse reactions. The response to treatment was analyzed using ANOVA and Fisher's exact test. Results Significant improvement in mouth opening, burning sensation and tongue protrusion was observed in all groups at 12 weeks. Mean improvement in burning sensation did not show statistical difference across the groups. A significant difference between groups II and III for improvement in mouth opening and groups I and III for improvement in tongue protrusion was noted. Conclusion When administrated in both systemic and topical forms together, curcumin showed better results in the management of oral submucous fibrosis as compared with the systemic form alone or antioxidants. Curcumin has the potential to emerge as an effective alternative to conventionally prescribed medications.

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“…15,16 Oral administration of curcumin was associated with an increase in vitamins C and E levels and a decrease in MDA and 8-hydroxydeoxyguanosine (8-OHdG) contents in the serum and saliva of patients with precancerous lesions.…”

Section: Oral Potentially Malignant Disordersmentioning

confidence: 99%

Cure from the rhizomes: the medicine behind the Indian saffron Curcumin

Sujatha

Priyadharshini

Shwetha

et al. 2018

Int J Basic Clin Pharmacol

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Indian system of medicine has always focused on cure from the nature. Plant products from the Indian household have been used as medicine to cure myriad of ailments since ancestral times. Curcumin is a polyphenol, an active ingredient found in turmeric. In Southeast Asia, turmeric has been used as a coloring, flavoring and as a therapeutic agent. The use of turmeric to treat ailments dates back to the times of Charaka and Shushrutha. It has been widely used as an antiseptic for cuts, burns, and bruises, and as an antibacterial agent. Modern medicine has begun to understand its importance in recent times. Unfortunately its poor solubility, limited absorption and enhanced metabolism limits its bioavailability for its extended therapeutic use. Integration of nanotechnology in drug design and development has led the way to development of nanocurcumin with improved pharmacological properties. A precise understanding of effective dose, safety, and mechanism of action is required for the rational use of turmeric in the treatment of human diseases. This review focuses on the molecular actions of curcumin and its possibility to be used as a therapeutic agent in conditions affecting oral mucosa.

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Comparison of curcumin with intralesional steroid injections in Oral Submucous Fibrosis – A randomized, open-label interventional study

Abstract: Turmix is beneficial and effective in reducing burning sensation in early OSMF patients.

Cited by 52 publications

References 12 publications

Curcumin as a Cure; Comparison of the Efficacy of Systemic and Topical Administration of Curcumin in Oral Submucous Fibrosis Patients: A Cross-Sectional Study

Curcumin as a Cure; Comparison of the Efficacy of Systemic and Topical Administration of Curcumin in Oral Submucous Fibrosis Patients: A Cross-Sectional Study

Comparative evaluation of curcumin and antioxidants in the management of oral submucous fibrosis

Cure from the rhizomes: the medicine behind the Indian saffron Curcumin

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