Comparison of critically ill COVID-19 and influenza patients with acute respiratory failure

Yıldırım, Mehmet; Halaçlı, Burçin; Pektezel, Mehmet Yasir; Er, Berrin; Geldigitti, Ismail Tuna; Tok, Gulay; Ersoy, Ebru; Topeli, Arzu

doi:10.4266/acc.2021.00920

Cited by 3 publications

(11 citation statements)

References 29 publications

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“…All studies were retrospective cohort studies. Five studies were conducted in the United States ( 18 , 19 , 21 , 23 , 24 ), two in China ( 27 , 29 ), one in France ( 20 ), one in Austria ( 22 ), one in Turkey ( 25 ), one in Israel ( 26 ), and one in Pakistan ( 28 ). Eight studies ( 18 , 19 , 22–24 , 26 , 28 , 29 ) reported data on general hospitalized patients, and four studies reported data on critically ill patients in ICUs ( 20 , 21 , 25 , 27 ) and patients with ARDS requiring veno-venous ECMO ( 20 ).…”

Section: Resultsmentioning

confidence: 99%

“…Five studies were conducted in the United States ( 18 , 19 , 21 , 23 , 24 ), two in China ( 27 , 29 ), one in France ( 20 ), one in Austria ( 22 ), one in Turkey ( 25 ), one in Israel ( 26 ), and one in Pakistan ( 28 ). Eight studies ( 18 , 19 , 22–24 , 26 , 28 , 29 ) reported data on general hospitalized patients, and four studies reported data on critically ill patients in ICUs ( 20 , 21 , 25 , 27 ) and patients with ARDS requiring veno-venous ECMO ( 20 ). Three studies ( 27–29 ) enrolled patients with H1N1 (subtype of influenza A), six studies ( 20–24 , 26 ) enrolled patients with type A or B influenza, while the other four studies ( 18 , 19 , 24 , 25 ) recruited influenza patients without mentioning the subtype.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies ( 18 , 19 , 22–24 , 26 , 28 , 29 ) reported data on general hospitalized patients, and four studies reported data on critically ill patients in ICUs ( 20 , 21 , 25 , 27 ) and patients with ARDS requiring veno-venous ECMO ( 20 ). Three studies ( 27–29 ) enrolled patients with H1N1 (subtype of influenza A), six studies ( 20–24 , 26 ) enrolled patients with type A or B influenza, while the other four studies ( 18 , 19 , 24 , 25 ) recruited influenza patients without mentioning the subtype. The meta-analysis included 8,634 patients with COVID-19 and 8,984 patients with influenza.…”

Section: Resultsmentioning

confidence: 99%

“…The effect size was quantified using the pooled odds ratio (OR) along with a 95% confidence interval (CI). Some studies ( 18 , 20 , 21 , 24 , 25 , 27–29 ) reported the length of hospital or ICU stays as a median with a range. To consolidate data, we estimated the mean and variance using a validated formula based on the reported median, range, and sample size ( 33 ).…”

Section: Methodsmentioning

confidence: 99%

“…The incidence of RRT was reported in five studies (19,21,(24)(25)(26). When these findings were pooled, the COVID-19 group exhibited an incidence of 4.10% (271 out of 6,609), while the influenza group showed an incidence of 1.51% (95 of 6,279).…”

Section: Renal Replacement Therapymentioning

confidence: 99%

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Acute kidney injury in patients with COVID-19 compared to those with influenza: a systematic review and meta-analysis

Hsiao,

Pan,

et al. 2023

Front. Med.

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BackgroundCOVID-19 and influenza can both lead to acute kidney injury (AKI) as a common complication. However, no meta-analysis has been conducted to directly compare the incidence of AKI between hospitalized patients with COVID-19 and influenza. The objective of our study aims to investigate the incidence and outcomes of AKI among hospitalized patients between these two groups.Materials and methodsA systematic search of PubMed, Embase, and Cochrane databases was conducted from December 2019 to August 2023 to identify studies examining AKI and clinical outcomes among hospitalized patients with COVID-19 and influenza. The primary outcome of interest was the incidence of AKI, while secondary outcomes included in-hospital mortality, recovery from AKI, hospital and ICU stay duration. The quality of evidence was evaluated using Cochrane and GRADE methods.ResultsTwelve retrospective cohort studies, involving 17,618 hospitalized patients with COVID-19 and influenza, were analyzed. COVID-19 patients showed higher AKI incidence (29.37% vs. 20.98%, OR: 1.67, 95% CI 1.56–1.80, p < 0.01, I2 = 92.42%), and in-hospital mortality (30.95% vs. 5.51%, OR: 8.16, 95% CI 6.17–10.80, p < 0.01, I2 = 84.92%) compared to influenza patients with AKI. Recovery from AKI was lower in COVID-19 patients (57.02% vs., 80.23%, OR: 0.33, 95% CI 0.27–0.40, p < 0.01, I2 = 85.17%). COVID-19 patients also had a longer hospital stay (SMD: 0.69, 95% CI 0.65–0.72, p < 0.01, I2 = 98.94%) and longer ICU stay (SMD: 0.61, 95% CI 0.50–0.73, p < 0.01, I2 = 94.80%) than influenza patients. In our study, evidence quality was high (NOS score 7–9), with low certainty for AKI incidence and moderate certainty for recovery form AKI by GRADE assessment.ConclusionCOVID-19 patients had higher risk of developing AKI, experiencing in-hospital mortality, and enduring prolonged hospital/ICU stays in comparison to influenza patients. Additionally, the likelihood of AKI recovery was lower among COVID-19 patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Renal Replacement Therapymentioning

confidence: 99%

See 3 more Smart Citations

Acute kidney injury in patients with COVID-19 compared to those with influenza: a systematic review and meta-analysis

Hsiao,

Pan,

et al. 2023

Front. Med.

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Comparison of Clinical Characteristics and Outcomes in Intensive Care Units Between Patients with Coronavirus Disease 2019 (COVID-19) and Patients with Influenza: A Systematic Review and Meta-Analysis

Zhong,

Wang,

Guo

et al. 2024

J Intensive Care Med

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Background Severe infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or influenza virus can cause patients to be admitted to intensive care units (ICUs). It is necessary to understand the differences in clinical characteristics and outcomes between these two types of critically ill patients. Methods We searched Embase, PubMed, and Web of Science for articles and performed a meta-analysis using Stata 14.0 with a random-effects model. This paper was written in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results Thirty-five articles involving 131,692 ICU patients with coronavirus disease 2019 (COVID-19) and 30,286 ICU patients with influenza were included in our meta-analysis. Compared with influenza patients, COVID-19 patients were more likely to be male (odds ratio (OR) = 1.75, 95% CI: 1.54-1.99) and older (standardized mean difference (SMD) = 0.16, 95% CI: 0.03-0.29). In terms of laboratory test results, COVID-19 patients had higher lymphocyte (SMD = 0.38, 95% CI: 0.17-0.59) and platelet counts (SMD = 0.52, 95% CI: 0.29-0.75) but lower creatinine (SMD = −0.29, 95% CI: −0.55-0.03) and procalcitonin levels (SMD = −0.78, 95% CI: −1.11-0.46). Diabetes (SMD = 1.27, 95% CI: 1.08-1.48) and hypertension (SMD = 1.30, 95% CI: 1.05-1.60) were more prevalent in COVID-19 patients, while influenza patients were more likely to have cancer (OR = 0.52, 95% CI: 0.44-0.62), cirrhosis (OR = 0.52, 95% CI: 0.44-0.62), immunodepression (OR = 0.38, 95% CI: 0.25-0.58), and chronic pulmonary diseases (OR = 0.35, 95% CI: 0.24-0.52). We also found that patients with COVID-19 had longer ICU stays (SMD = 0.20, 95% CI: 0.05-0.34), were more likely to develop acute respiratory distress syndrome (OR = 4.90, 95% CI: 2.77-8.64), and had higher mortality (OR = 1.35, 95% CI: 1.17-1.55). Conclusions There are some differences in the basic characteristics, comorbidities, laboratory test results and complications between ICU patients with COVID-19 and ICU patients with influenza. Critically ill patients with COVID-19 often require more medical resources and have worse clinical outcomes. PROSPERO Registration Number: CRD42023452238

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Comparison of Clinical Features and Outcomes between SARS-CoV-2 and Non-SARS-CoV-2 Respiratory Viruses Associated Acute Respiratory Distress Syndrome: Retrospective Analysis

Heo

Jeong

et al. 2022

JCM

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Although a few studies comparing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and non-SARS-CoV-2 respiratory viruses have been reported, clinical features and outcomes comparing SARS-CoV-2 and non-SARS-CoV-2 respiratory viruses associated acute respiratory distress syndrome (ARDS) are still lacking. We retrospectively identified patients with SARS-CoV-2 (November 2020 to January 2022) and non-SARS-CoV-2 respiratory viruses associated ARDS (February 2015 to November 2020) at a single tertiary hospital. Their clinical data were obtained by medical record review. All viral infections were confirmed by RT-PCR. Thirty-one SARS-CoV-2 and seventy-one patients with non-SARS-CoV-2 respiratory viruses associated ARDS patients were identified. Influenza (62%) was the most common in non-SARS-CoV-2 respiratory viruses associated ARDS patients. Patients with SARS-CoV-2 were more likely to be female and had higher body mass index, lower clinical frailty, APACHE II, and SOFA score than those with non-SARS-CoV-2 respiratory viruses. All patients with SARS-CoV-2 were treated with corticosteroids and used more high-flow nasal oxygen than those with non-SARS-CoV-2 respiratory viruses. The concomitant respiratory bacterial infection was significantly higher in non-SARS-CoV-2 respiratory viruses than SARS-CoV-2. Although there were no significant differences in the 28-, 60-day, and in-hospital mortality rates between SARS-CoV-2 and non-SARS-CoV-2 respiratory viruses associated ARDS, the duration of mechanical ventilation and length of hospital stay were significantly longer in patients with SARS-CoV-2 than those with non-SARS-CoV-2 respiratory viruses. Although the severity of illness and the concomitant bacterial infection rate were lower in patients with SARS-CoV-2 associated ARDS, mortality rates did not differ from non-SARS-CoV-2 respiratory viruses associated ARDS.

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Comparison of critically ill COVID-19 and influenza patients with acute respiratory failure

Cited by 3 publications

References 29 publications

Acute kidney injury in patients with COVID-19 compared to those with influenza: a systematic review and meta-analysis

Acute kidney injury in patients with COVID-19 compared to those with influenza: a systematic review and meta-analysis

Comparison of Clinical Characteristics and Outcomes in Intensive Care Units Between Patients with Coronavirus Disease 2019 (COVID-19) and Patients with Influenza: A Systematic Review and Meta-Analysis

Comparison of Clinical Features and Outcomes between SARS-CoV-2 and Non-SARS-CoV-2 Respiratory Viruses Associated Acute Respiratory Distress Syndrome: Retrospective Analysis

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