Comparison of CPP-ACP, Tri-Calcium Phosphate and Hydroxyapatite on Remineralization of Artificial Caries Like Lesions on Primary Enamel -An in vitro Study

Bajaj, Meghna; Poornima, P; Praveen, S B; Nagaveni, N B; Roopa, KB; Neena, IE; Bharath, K P

doi:10.17796/1053-4628-40.5.404

Cited by 30 publications

(39 citation statements)

References 26 publications

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“…TCP signi cant remineralizing effect is clari ed by the high levels of calcium and phosphorus ions in addition to the presence of uoride ions in the saliva which is considered as an appropriate remineralization solution which encourage the remineralization of the initial carious lesions. The results agreed with Bajaj et al, (26) who treated initial carious lesions with functional TCP milled with sodium lauryl sulfate. Enamel remineralization of different calcium-phosphate and uoride delivery systems were assessed with Vyavhare et al, (27) who compared the remineralization potential of uoride, nano-hydroxyapatite, and CPP-ACP and they stated that tested materials had high remineralization potential of uoride.…”

Section: Discussionsupporting

confidence: 91%

Impact of Two Remineralizing Agents on White Spot Lesions

Alagha

2020

Preprint

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Aim of the study: This study evaluated the impact of two remineralizing agents containing casein phosphopeptideamorphous calcium phosphate (CPPACP), and Tricalcium phosphate (TCP) on white spot lesions. Materials and Methods: A total of ninety freshly extracted upper premolars were divided in three equal groups (30 each). Group A: Control group. Group B: Varnish containing CPP–ACP. Group C: Varnish containing TCP. The teeth were subjected to Diagnodent test after inducing white spot lesions to assess any surface changes present on the teeth. The readings were repeated post demineralization and post-remineralization. Results: Statistically significant difference was present in the mean values between the tested groups. CPP-ACP group recorded higher mean value at demineralization when compared to TCP group. Statistically significant difference (p < 0.0001) was present between the baseline and the demineralization values. CPP-ACP group presented higher remineralization results when compared to TCP group. T-test proved a significant difference between the tested groups. Conclusion: CPP-ACP containing varnish had higher remineralizing effect when compared to TCP containing varnish. Clinical Significance: Recently, the focus of restorative dentistry has been directed toward a conservative approach. Prevention and non-restorative treatment of initial enamel caries is the main concern. Remineralization procedures are the most preferred way of regeneration of lost tooth structure.

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Section: Discussionsupporting

confidence: 91%

Impact of Two Remineralizing Agents on White Spot Lesions

Alagha

2020

Preprint

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“…Evidence-based review and research studies on the calcium phosphate agent for prevention of tooth caries in children indicated that calcium and phosphate ion promote remineralization of early enamel caries,[37383940414243444546474849] which is in line with the results of this study; however, which type of calcium phosphate compound is the best remineralizing agent is still controversial. [4243444546474849]…”

Section: Discussionsupporting

confidence: 85%

The efficiency of child formula dentifrices containing different calcium and phosphate compounds on artificial enamel caries

Rirattanapong¹,

Vongsavan²,

Saengsirinavin³

et al. 2016

J Int Soc Prevent Communit Dent

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Objectives:Fluoride toothpaste has been extensively used to prevent dental caries. However, the risk of fluorosis is concerning, especially in young children. Calcium phosphate has been an effective remineralizing agent and is present in commercial dental products, with no risk of fluorosis to users. This in vitro study aimed to compare the effects of different calcium phosphate compounds and fluoride-containing dentifrices on artificial caries in primary teeth.Materials and Methods:Fifty sound primary incisors were coated with nail varnish, leaving two 1 mm2 windows on the labial surface before immersion in demineralizing solution for 96 hours to produce artificial enamel lesions. Subsequently, one window from each tooth was coated with nail varnish, and all 50 teeth were divided into five groups (n = 10); group A – deionized water; group B – casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) paste (Tooth Mousse); group C – 500 ppm F (Colgate Spiderman®); group D – nonfluoridated toothpaste with triple calcium phosphate (Pureen®); and group E – tricalcium phosphate (TCP). Polarized light microscopy and Image-Pro® Plus software were used to evaluate lesions.Results:After a 7-day pH-cycle, mean lesion depths in groups A, B, C, D, and E had increased by 57.52 ± 10.66%, 33.28 ± 10.16%, 17.04 ± 4.76%, 32.51 ± 8.99%, and 21.76 ± 8.15%, respectively. All data were processed by the Statistical Package for the Social Sciences (version 16.0) software package. Comparison of percentage changes using one-way analysis of variance and Fisher's least squares difference tests at a 95% level of confidence demonstrated that group A was significantly different from the other groups (P < 0.001). Lesions in groups B and D had a significant lesion progression when compared with groups C and E.Conclusions:All toothpastes in this study had the potential to delay the demineralization progression of artificial enamel caries in primary teeth. The fluoride 500 ppm and TCP toothpastes were equal in the deceleration of enamel caries progression and better than CPP–ACP paste and TCP toothpaste.

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“…Tschoppe et al (17) evaluated the effects of a toothpaste containing NHA on enamel and dentin remineralization and showed that NHA toothpaste had greater efficacy for enamel and dentin remineralization than amine fluoride toothpaste. Bajaj M. et al (18) compared CPP-ACP, Tri-calcium phosphate and Hydroxyapatite on remineralization of artificial caries like lesions on primary enamel, showed that Hydroxyapatite had better remineralization efficacy when compared to CPP-ACP and Tri-calcium phosphate.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of the remineralization potential of CPP–ACP with Fluoride, Tri-Calcium Phosphate and Nano Hydroxyapatite using SEM/EDX – An in vitro study

Thimmaiah¹,

Shetty

et al. 2019

J Clin Exp Dent

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BackgroundIn recent years, the non-invasive management of non cavitated caries lesions using remineralization systems to repair the enamel have received more attention from the scientific community. Aim: To quantitatively evaluate the remineralization potential of Casein phosphopeptide-amorphous calcium phosphate-fluoride(CPP-ACPF), Tri-calcium phosphate(TCP) & Nano-hydroxyapatite(nHAP) using Scanning Electron Microscopy(SEM) and Energy dispersive X-ray Analysis(EDX).Material and Methods40 enamel specimens were prepared, and immersed in demineralising solution at a pH of 4.4 for 96 hours at 37°C, to induce artificial carious lesions. Remineralization was carried out for a period of 30 days using CPP-ACPF, TCP, nHAP. The specimens were evaluated for calcium and phosphorus content using SEM-EDX.ResultsThe Ca/P mass % after remineralization was significantly higher with CPP-ACP-F and TCP-F followed by nHAP.ConclusionsCPP-ACP-F and TCP can promote significant remineralization of incipient carious lesions. These are excellent delivery vehicles available in a slow release amorphous form to localize calcium, phosphate and fluoride at the tooth surface. Key words:Remineralization, in vitro; CPP-ACP fluoride, Nano-hydroxyapatite, Tri-calcium phosphate, SEM/ EDX.

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Comparison of CPP-ACP, Tri-Calcium Phosphate and Hydroxyapatite on Remineralization of Artificial Caries Like Lesions on Primary Enamel -An in vitro Study

Abstract: Hydroxyapatite showed better remineralization when compared to CPP-ACP and Tri-calcium phosphate.

Cited by 30 publications

References 26 publications

Impact of Two Remineralizing Agents on White Spot Lesions

Impact of Two Remineralizing Agents on White Spot Lesions

The efficiency of child formula dentifrices containing different calcium and phosphate compounds on artificial enamel caries

Comparative analysis of the remineralization potential of CPP–ACP with Fluoride, Tri-Calcium Phosphate and Nano Hydroxyapatite using SEM/EDX – An in vitro study

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