Purpose: Conventional Laparoscopic Cholecystectomy (CLC) is the "gold standard" approach for patients with gallstones. Single-incision Laparoscopic Cholecystectomy (SILC) was an alternative technique, purportedly offering several postoperative benefi ts over CLC. Studies comparing short-term postoperative outcomes of SILC versus CLC have yielded confl icting results. Our paper aims to compare the long-term postoperative outcomes of patients undergoing SILC and CLC with a minimum follow up of seven years. Methods: A comparative retrospective study between SILC and CLC was conducted among 118 patients undergoing cholecystectomy from October 2008 to December 2010 (SILC=67/CLC=61). An initial retrospective chart review was performed. We later surveyed the patients who had undergone cholecystectomy by telephone interview at a mean(sd) of 4(0.75) years, and at 8(0.75) years. Postoperative outcomes were evaluated. Results: No signifi cant difference between SILC and CLC groups for daily pain scores (p = 0.45 and 0.97, for day 1 and 2, respectively), daily narcotic requirements (p = 0.09 and 0.85, for day 1 and 2, respectively), and time to return to normal activity (p = 0.11). The mean(sd) operative time was greater in SILC group [52(2.0) mins versus 36(2.3) mins; p <0.05]. There was a shorter mean(sd) length of stay postoperatively in the SILC group [2(0.11) days versus 3(0.32) days; p <0.05]. The SILC group had a higher median(sd) cosmetic satisfaction score (IQR) than the CLC group at both the intermediate-term [10(10) versus 9(8 to10); p <0.05] and long-term [10(10) versus 9(9to10); p <0.05] follow up. Conclusion: SILC is associated with higher patient cosmetic satisfaction than CLC. However, the procedure is more technically challenging and associated with increased operating time and costs. The marginal cosmetic benefi t at the expense of increased operative time and economic costs will likely mean that the choice of procedure will be largely patient rather than physician driven.