Comparison of correlations between lipid profile and different computed tomography fatty liver criteria in the setting of incidentally noted fatty liver on computed tomography examinations

Jawahar, A.; González, Beverly; Balasubramanian, Neelam; Adams, William M.; Goldberg, Allen I.

doi:10.1097/meg.0000000000000972

Cited by 14 publications

(17 citation statements)

References 40 publications

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“…Previous studies have reported that hepatic steatosis on CT is associated with dyslipidemia, the presence of diabetes, alcoholism, and hypertension [ 15 , 16 ]. Other recent studies have shown that incidentally detected hepatic steatosis determined by various CT criteria is associated with an abnormal lipid profile, abnormal liver function, and certain comorbidities [ 8 , 9 ]. In our study, we sought to validate the association in a health screening population, specifically in the setting of NAFLD, by excluding those with hepatitis B or C virus infection or alcoholism.…”

Section: Discussionmentioning

confidence: 99%

“…Splenic attenuation was measured by averaging HU values of three 2 cm 2 circular ROIs placed at three different sites in the middle third of the spleen. To measure hepatic and splenic attenuation, ROIs were placed to exclude macroscopic hepatic vessels, biliary structures, and any focal liver lesions, and they were at least 5–10 mm away from the periphery of the liver [ 8 ] ( Figure 2 ). The same measurement process was performed in two sessions, and each session was scheduled a week apart to minimize recall bias.…”

Section: Methodsmentioning

confidence: 99%

“…HSI was calculated according to a previous study: HSI = 8 × ALT-AST ratio + BMI (+2 if diabetes; +2 if female) [10]. Three criteria using non-enhanced CT, which were proposed in the previous literature [5,8,14], were applied for the diagnosis of hepatic steatosis: (a) absolute liver attenuation value (HU liver ) < 48, (b) the liver-to-spleen HU ratio (CT L/S ) < 0.8, and (c) attenuation difference between the liver and spleen (CT L-S ) < −10.…”

Section: Clinical Informationmentioning

confidence: 99%

“…Several studies have investigated the association of NAFLD with clinical and biochemical parameters and devised prediction models [ 2 , 8 , 9 , 10 , 11 , 12 ]. One of the studies suggested the hepatic steatosis index (HSI) using liver enzyme levels and body mass index (BMI) for the screening of NAFLD in a certain screening population, which was based on hepatic steatosis diagnosed by ultrasonography [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Hepatic Steatosis Index with Nonalcoholic Fatty Liver Disease Diagnosed by Non-Enhanced CT in a Screening Population

et al. 2021

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The noninvasive diagnosis of hepatic steatosis is of increasing concern. This study investigated the association of hepatic steatosis determined by non-enhanced CT criteria with clinical parameters in a screening population. Asymptomatic patients who underwent abdominal CT at our healthcare center were retrospectively analyzed (n = 339). Two radiologists measured the attenuation values of the liver parenchyma and spleen using non-enhanced CT images. CT criteria for hepatic steatosis were (a) absolute liver attenuation value <48 Hounsfield units (HU), (b) liver-to-spleen attenuation ratio <0.8, and (c) attenuation difference between the liver and spleen <−10. Body mass index (BMI) and hepatic steatosis index (HSI) were calculated, and laboratory findings were recorded. The association of hepatic steatosis with clinical parameters was assessed using univariate and logistic regression analyses. The presence of hepatic steatosis was significantly associated with the levels of serum fasting glucose and triglycerides, the alanine aminotransferase to aspartate aminotransferase (ALT/AST) ratio, BMI, and HSI values using any of the CT criteria. Logistic regression analysis revealed that the serum fasting glucose level and HSI were significantly associated with hepatic steatosis using criterion (a), while the ALT/AST ratio and HSI were associated with hepatic steatosis using criteria (b) and (c). The presence of hepatic steatosis on non-enhanced CT should be considered to indicate possible clinical profile abnormalities regarding metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Clinical Informationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Hepatic Steatosis Index with Nonalcoholic Fatty Liver Disease Diagnosed by Non-Enhanced CT in a Screening Population

et al. 2021

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“…Despite increasing awareness in recent years, the prevalence is increasing and its prevalence varies relying upon the country, age, sex, ethnicity, and related risk factors. NAFLD is believed as one of the most well-known reasons for chronic liver disease all over the world [2,3].…”

Section: Introductionmentioning

confidence: 99%

Lipid Profile Response to Electroacupuncture in Non-Alcoholic Fatty Liver Patients with Hyperlipidemia

Mohamed

Ismail

Draz

2021

J Acupunct Meridian Stud

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Background: Non-alcoholic fatty liver disease (NAFLD) is estimated to be one of the most common diseases affecting the liver because of its high prevalence worldwide. Abnormal lipid profile between NAFLD patients has been reported in several studies. Objectives: This study aimed to evaluate the lipid profile response to electroacupuncture in NAFLD patients. Methods: A total of 60 female patients with NAFLD were included in the study with ages ranged from (30-55) years old. They were divided equally into two groups, group A received electroacupuncture (EA) stimulation at points of; LR14, LR3, ST36, and GB34. And group B received sham acupuncture application in non-acupuncture points. The demographic data and lipid profile such as total cholesterol (TC), serum triglycerides (TG), serum high-density lipoprotein (HDL), serum low-density lipoprotein (LDL) were recorded before and after the study. Results: The study results revealed a significant decrease (p < 0.05) of LDL, TC, TG after 6 weeks of non-interrupted treatment sessions in group A, However HDL showed no significant improvement (p > 0.05). A significant difference was found between posttreatment values of LDL, TC, and TG between both groups. Conclusion: Electroacupuncture can be an effective, simple, and applicable method for the improvement of elevated lipid profiles in NAFLD patients.

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Effects of CPAP on Metabolic Syndrome in Patients With OSA

Giampá

Furlan

Freitas

et al. 2022

Chest

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Comparison of correlations between lipid profile and different computed tomography fatty liver criteria in the setting of incidentally noted fatty liver on computed tomography examinations

Abstract: Incidental reporting of fatty liver on NECT/CECT should prompt consideration of clinical follow-up and lipid profile testing in an otherwise asymptomatic patient. Additional metrics for the diagnosis of steatosis in CECT exam should also be considered.

Cited by 14 publications

References 40 publications

Association of Hepatic Steatosis Index with Nonalcoholic Fatty Liver Disease Diagnosed by Non-Enhanced CT in a Screening Population

Association of Hepatic Steatosis Index with Nonalcoholic Fatty Liver Disease Diagnosed by Non-Enhanced CT in a Screening Population

Lipid Profile Response to Electroacupuncture in Non-Alcoholic Fatty Liver Patients with Hyperlipidemia

Effects of CPAP on Metabolic Syndrome in Patients With OSA

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