Comparison of coronary plaque, coronary artery calcification and major adverse cardiac events in Chinese outpatients with and without type 2 diabetes

Zhu, Lihua; Liu, Jingjing; Gao, Chuanyu; Zhao, Wenli; Que, Jing; Wang, Xianpei; Qi, Datun; Li, Jun; Xiao, Wei; Yan, Jing; Li, Wentao; Zhang, You; Yang, Haiyan

doi:10.1186/s40064-016-3373-0

Cited by 9 publications

(5 citation statements)

References 37 publications

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“…This in turn triggers a vasoconstriction reflex as well as systemic inflammation, causing more severe myocardial dysfunction, mortality, and MACE [11]. Similar to our findings, patients with diabetes mellitus were found to have less favorable angiographic outcomes following coronary stent placement and higher incidence of MACE compared to the nondiabetic patients as investigated in multiple previous studies [12][13][14]. Diabetes was associated with higher incidence of death, MI, reinterventions, and increased risk of restenosis [12].…”

Section: Discussionsupporting

confidence: 85%

Predictors of the Development of Major Adverse Cardiac Events following Percutaneous Coronary Intervention

Azaza¹,

Baslaib²,

Rishani³

et al. 2022

Dubai Med J

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Background: Coronary artery disease remains the greatest cause of morbidity and mortality worldwide despite the growing access to percutaneous coronary intervention (PCI). Data regarding the factors predicting the development of major adverse cardiac events (MACE) in patients undergoing PCI are, however, lacking in the gulf region. In this study, we analyze demographics and risk profile of all patients undergoing PCI in a tertiary cardiovascular center located in Dubai – UAE. In our study, we aimed to analyze the risk profile of all patients undergoing PCI and determine the independent predictors of MACE. Methods: Data were collected prospectively on all patients who underwent PCI in our hospital between September 2017 and September 2018. Patients aged 18 years and above were included in the study and there were no exclusion criteria. The definition of MACE was a composite of death, in-hospital recurrent myocardial infarction (MI), in-hospital target vessel revascularization (TVR), and stroke. The patients’ characteristics, risk factor, and demographics were analyzed to identify the predictors of MACE using logistic regression model which is presented in odds ratio. Results: Data were available for 789 patients. Of these, 741 (94%) were male. The mean age was 52 ± 11 years. Twenty-two (3%) patients died, 7 (1%) had an in-hospital recurrent MI, 6 (1%) had in-hospital TVR, and 1 (0.1%) had a stroke. Of the patients who died, 16 (73%) patients presented with cardiogenic shock. Major adverse cardiovascular events occurred in 29 (3.7%) patients. In the multivariable regression model, only cardiogenic shock (odds ratio [OR] = 32.43) and the presence of diabetes mellitus (OR = 3.36) were predictors of MACE. Conclusion: Our study showed that cardiogenic shock and diabetes mellitus are the independent predictors of MACE in patients undergoing PCI.

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Section: Discussionsupporting

confidence: 85%

Predictors of the Development of Major Adverse Cardiac Events following Percutaneous Coronary Intervention

Azaza¹,

Baslaib²,

Rishani³

et al. 2022

Dubai Med J

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“…Diabetic nephropathy probably had an independent effect on E / e ratio, left ventricular diastolic dysfunction and cardiac valve regurgitation ( 62 ). In addition, diabetes patients are with a higher coronary artery calcification (CAC) score, and incidence rate of major adverse cardiovascular events ( 63 ). A higher CAC score was significantly associated with fibroblast growth factor 23, parathyroid hormone, and inflammation index ( 64 ).…”

Section: Discussionmentioning

confidence: 99%

Associated factors of cardiac valve calcification and its prognostic effects among patients with chronic kidney disease: a systematic review and meta-analysis

Zhang

Pang

Wang

et al. 2023

Front. Cardiovasc. Med.

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BackgroundCardiac valve calcification (CVC) is highly prevalent and a risk factor for adverse outcomes in patients with chronic kidney disease (CKD). This meta-analysis aimed to investigate the risk factors for CVC and association between CVC and mortality in CKD patients.MethodThree electronic databases including PubMed, Embase, and Web of Science were searched for relevant studies up to November 2022. Hazard ratios (HR), odds ratios (OR), and 95% confidence intervals (CI) were pooled using random-effect meta-analyses.Results22 studies were included in the meta-analysis. Pooled analyses showed that CKD patients with CVC were relatively older, had a higher body mass index, left atrial dimension, C-reaction protein level, and a declined ejection fraction. Calcium and phosphate metabolism dysfunction, diabetes, coronary heart disease, and duration of dialysis were all predictors for CVC in CKD patients. The presence of CVC (both aortic valve and mitral valve) increased the risk of all-cause and cardiovascular mortality in CKD patients. However, the prognostic value of CVC for mortality was not significant anymore in patients with peritoneal dialysis.ConclusionCKD patients with CVC had a greater risk of all-cause and cardiovascular mortality. Multiple associated factors for development of CVC in CKD patients should be taken into consideration by healthcare professionals to improve prognosis.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier [CRD42022364970].

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“…Severe coronary artery calcification increases the risks of interventional procedures, and patients have a poor prognosis [2]. Diabetes mellitus is a primary cause of vascular calcification [3]. The mechanism through which diabetes mellitus promotes vascular calcification is not clear.…”

Section: Introductionmentioning

confidence: 99%

Glycemic variability is associated with vascular calcification by the markers of endoplasmic reticulum stress-related apoptosis, Wnt1, galectin-3 and BMP-2

Zhang

Sun

Liu

et al. 2019

Diabetol Metab Syndr

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Background The present study identified whether glycemic variability (GV) was associated with vascular calcification and explored the underlying mechanisms. Methods Eighty-four consecutive type 2 diabetic patients with unstable angina (UA) were included from January 2018 to June 2018 to calculate calcification scores using computerized tomographic angiography (CTA), and the patients were divided into 2 groups: high calcification score group (HCS group) and low calcification score group (LCS group). Intergroup differences in GV were determined via comparisons of the standard deviation (SD) of blood glucose. Calcification staining, content measurement, apoptosis evaluation and Western blot analysis of endoplasmic reticulum (ER) stress-related apoptosis, Wnt1, galectin-3 and bone morphogenetic protein-2 (BMP-2) were compared in cell cultures from rat vascular smooth muscle cells in the different degrees of GV. Results The SD increased significantly with the increases in calcification scores from human studies (HCS group 2.37 ± 0.82 vs. LCS group 1.87 ± 0.78, p = 0.007). Multivariate logistic regression analysis suggested that increased SD and serum creatinine were independent predictors of calcification. The high GV group had a higher apoptotic rate, higher calcification content and higher expressions of glucose-regulated protein, caspase-3, Wnt1, galectin-3 and BMP-2 markers compared to the low GV group in the in vitro studies ( p < 0.001). Conclusion We report the novel finding that GV is associated with vascular calcification, and ER stress-related apoptosis, Wnt1, galectin-3 and BMP-2 may be involved in this regulation.

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Comparison of coronary plaque, coronary artery calcification and major adverse cardiac events in Chinese outpatients with and without type 2 diabetes

Cited by 9 publications

References 37 publications

Predictors of the Development of Major Adverse Cardiac Events following Percutaneous Coronary Intervention

Predictors of the Development of Major Adverse Cardiac Events following Percutaneous Coronary Intervention

Associated factors of cardiac valve calcification and its prognostic effects among patients with chronic kidney disease: a systematic review and meta-analysis

Glycemic variability is associated with vascular calcification by the markers of endoplasmic reticulum stress-related apoptosis, Wnt1, galectin-3 and BMP-2

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