Comparison of coronary arterial lumen dimensions on angiography and plaque characteristics on optical coherence tomography images and their changes induced by statin

Abstract

BackgroundCoronary angiography (CAG) is widely used to assess lumen dimensions, and optical coherence tomography (OCT) is used to evaluate the characteristics of atherosclerotic plaque. This study was aimed to compare coronary lumen dimensions using CAG and plaque characteristics using OCT and their changes during statin therapy.MethodsWe identified 97 lipid-rich plaques from 69 statin-naïve patients, who received statin therapy in the following 12 months. CAG and OCT examinations were conducted at baseline and 12-month follow-up period.ResultsLesion length, as measured by CAG, was closely correlated with lipid length by OCT (baseline: r = 0.754, p < 0.001; follow-up: r = 0.639, p < 0.001). However, no significant correlations were found between the other findings on OCT and data on CAG. With 12-month statin therapy, microstructures of lipid-rich plaques were significantly improved, but CAG-derived lumen dimensions were not improved. Moreover, we found no significant relationship between changes in OCT measurements and changes in CAG data over time.ConclusionLipid length on OCT and lesion length on CAG were closely correlated. However, plaque microstructural characteristics on OCT showed no significantly statistically correlations with lumen dimensions on CAG, neither did their evolutionary changes induced by statin over time.A retrospectively registered studyClinical trial registry: ClinicalTrial.gov. Registered number: NCT01023607. Registered 1 December 2009.

Optical coherence tomography angiography: A new tool in glaucoma diagnostics and research

“…In cardiology, OCT is used for evaluation of thrombotic plaques, atherosclerotic plaques, and intravascular stents. [ 58 59 60 61 62 ] In neuroscience, OCTA has been proposed as a means for evaluating stroke, traumatic brain injuries and subarachnoid hemorrhage. [ 63 ] In dermatology, OCT has become a popular tool for evaluation of various skin disorders in the clinic[ 64 65 66 67 68 ] and OCTA is used for exploring vascular skin lesions.…”