Comparison of copeptin B-type natriuretic peptide and amino-terminal pro-B-Type natriuretic peptide in patients with Chronic Heart Failure: Prediction of death at different stages of the disease

Neuhold, Stephanie; Huelsmann, M; Strunk, Guido; Stoiser, Brigitte; Struck, Joachim; Morgenthaler, N. G.; Bergmann, Andreas; Gouya, Ghazaleh; Elhenicky, Marie; Pacher, Richard

doi:10.1016/s1567-4215(08)60319-7

Cited by 75 publications

(122 citation statements)

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“…Copeptin's effects are mediated via VI and V2 receptors leading to progression of left ventricular hypertrophy and myocardial remodeling [57][58][59]. The study also demonstrated a lack of correlation between sodium and copeptin in this study, possibly explained by the complex underlying physiology of water and sodium regulation.…”

Section: Copeptinmentioning

confidence: 74%

“…Studies have shown that due to limited availability, and rapid clearance from the circulation, measuring AVP in the plasma is difficult [56,57]. Copeptin is secreted from the AVP precursor protein along with AVP and neurophysin II, and due to its stability in the plasma, measuring copeptin levels are beneficial.…”

Section: Copeptinmentioning

confidence: 99%

“…Copeptin is secreted from the AVP precursor protein along with AVP and neurophysin II, and due to its stability in the plasma, measuring copeptin levels are beneficial. The main function of AVP is in maintaining hemodynamic stability by reabsorbing water at the renal tubules in direct response to changing plasma volume and osmolality [57][58][59].…”

Section: Copeptinmentioning

confidence: 99%

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Biomarkers for Diagnosis and Prognosis of Acute Heart Failure

Choudhary

Somma

Maisel

2013

Curr Emerg Hosp Med Rep

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High mortality, morbility and hospitalization as a result of acute heart failure (AHF) represents an increasing public health dilemma. A prompt and appropriate therapeutic approach in the management of AHF has been demonstrated to be of great importance in reducing patient mortality and in-hospital length of stay. As consequence, at the moment of patient presentation, it is of great importance to make a fast and accurate diagnosis and risk stratification. Although an global clinical evaluation is mandatory, in some cases the signs and instrumental findings are not sufficient for a complete patient's diagnosis and risk stratifications. Multiple studies demonstrated that biomarkers assessment plus clinical judgement provide additional diagnostic and prognostic value in AHF patients. Moreover, data from the literature demonstrated the utility of a multimarkers approach in patients with heart failure in order to ameliorate diagnostic and prognostic accuracy. This paper is dedicated to addressing the actual state of the art on the utility in the management of acute heart failure of the following biomarkers: natriuretic peptides, procalcitonin, MRproADM, copeptine, neutrophil gelatinase associated lipocalin and galectin 3.

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Section: Copeptinmentioning

confidence: 74%

Section: Copeptinmentioning

confidence: 99%

Section: Copeptinmentioning

confidence: 99%

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Biomarkers for Diagnosis and Prognosis of Acute Heart Failure

Choudhary

Somma

Maisel

2013

Curr Emerg Hosp Med Rep

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“…2-Kopeptin: Öncü vazopressin'in C-uç parçası olan bu belirteç, iki geniş erişkin hasta grubunda yapılan çalışmada, kalp yetersizliğinde mortaliteyi belirlemede BNP ve NT-proBNP'den daha güçlü bir belirteç olduğunu göster-miştir (12).…”

Section: Miyokardiyal Hasarı Göstermede Gelişmekte Olan Biyo-belirteçunclassified

Biomarkers in cardiovascular surgery biomarkers as early predictors for organ damage after cardiac surgery

Bozkaya¹

2015

MUSBED

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“…El NTproBNP es eliminado principalmente vía renal, 50 . Dentro de los biomarcadores más recientes y que ha generado mayor interés, se encuentra la copeptina, la que demostró ser un potente predictor de mortalidad en pacientes con IC, especialmente aquellos con síntomas leves o moderados, que son más difíciles de evaluar en forma ambulatoria, en el trabajo de Neuhold et al 51 ; lo que la transforma en una nueva herramienta de trabajo 52 , con la idea de identificar a los pacientes que se podrían beneficiar de un tratamiento con drogas antagonistas de los receptores renales de la vasopresina.…”

Section: Utilidad Clínicaunclassified