“…Following the introduction of the iso-inertial YoYo™ technology as a viable and physiologically sound exercise device for space crew (Berg and Tesch, 1994), mounting evidence suggests this solution offers, and mediates, unique physiological responses and benefits beyond what is possible by means of other established resistance exercise interventions (Norrbrand et al, 2008, 2010, 2011; Cuenca-Fernandez et al, 2015). There is sparse, yet growing evidence that this method also has important clinical applications and could serve geriatric populations and athletes and other patients in need of rehabilitation following muscle wasting or orthopedic/neurological trauma (Greenwood et al, 2007; Onambele et al, 2008; Romero-Rodriguez et al, 2011; Fernandez-Gonzalo et al, 2014c; Sarmiento et al, 2014; Abat et al, 2015; Oliveira et al, 2015; Gual et al, 2016; Fernandez-Gonzalo et al, 2016a). This review covers research, pertinent to clinical applications, which has made use of, and explored the efficacy of, this novel resistance exercise paradigm favoring eccentric overload.…”