Comparison of Conventional Periodontal Maintenance Versus Scaling and Root Planing With Subgingival Minocycline

Meinberg, Trudy A.; Barnes, Caren M.; Dunning, David G.; Reinhardt, Richard

doi:10.1902/jop.2002.73.2.167

Cited by 30 publications

(36 citation statements)

References 31 publications

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“…The observed increase in bone density in group I is in agreement with the observation of Bezerra et al (5) who found that the animals subjected to 7 days of treatment for periodontitis with subcutaneous Mx (0.75, 1.5, 3 mg/ Kg) exhibited a dose-dependent inhibition of alveolar bone loss that was significantly different from that of untreated groups. The current study results of group II are in accordance with those of a previous study (44), where minocycline microspheres application diminished bone resorption and increased alveolar bone height.…”

Section: In Vitro Determination Of the Antibacterial Activity Of Mh Gsupporting

confidence: 92%

Comparative Study to Investigate the Effect of Meloxicam or Minocycline HCl In Situ Gel System on Local Treatment of Periodontal Pockets

et al. 2014

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Abstract. In situ gelling formulations allow easy application to the target area. Gelation is induced by physiological stimuli at the site of application where the formula attains semisolid properties and exerts sustained drug release. In situ gelling formulations containing either 3% meloxicam (Mx) or 2% minocycline HCl (MH) were prepared for local application into the periodontal pockets. Gel formulations were based on the thermosensitive Pluronic ® (Pl) and the pH-sensitive Carbopol ® (C) polymers. C gels were prepared in combination with HPMC (H) to decrease its acidity. The total percent drug released from Pl formulae was 21.72% after 1 week for Mx and 85% after 3 days for MH. Their release kinetics data indicated anomalous non-Fickian behavior that could be controlled by both diffusion and chain relaxation. Addition of MH to C/H gels (1:2.5) resulted in liquefaction, followed by drug precipitation. Regarding C/H gel containing Mx, it showed a prolonged release rate up to 7 days with an initial burst effect; the kinetics data revealed Fickian-diffusion mechanism. The in vitro antibacterial activity studies for MH gel in Pl revealed that the drug released exceeded the minimum inhibitory concentration (MIC) of MH against Staphylococcus aureus ATCC 6538; placebo gel showed no effect on the microorganism. Clinical evaluation of Pl gels containing either Mx or MH showed significant improvement in chronic periodontitis patients, manifested by decrease in pocket depth and gingival index and increase in bone density.

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Section: In Vitro Determination Of the Antibacterial Activity Of Mh Gsupporting

confidence: 92%

Comparative Study to Investigate the Effect of Meloxicam or Minocycline HCl In Situ Gel System on Local Treatment of Periodontal Pockets

et al. 2014

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“…This material has been used in combination with hydroxyapatite to prepare microspheres containing amoxicillin, amoxicillin-clavulanic acid or erythromycin [106]. In Table 1, we provide a few examples of polymeric materials that were been used for periodontal applications [82,91,93,99,101,102,107-110,116-118,123,125,126]. …”

Section: Microparticulate Delivery Systems and Periodontal Diseasesmentioning

confidence: 99%

“…Studies for determining the clinical efficacy of microspheres containing minocycline (Arestin) in comparison with that of a chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections was carried out by Renvert et al [117,118]. The results demonstrated that local use of the microencapsulated antibiotic as an adjunct to mechanical treatment was effective for peri-implant lesions, with better results than with chlorhexidine gel.…”

Section: Microparticulate Delivery Systems and Periodontal Diseasesmentioning

confidence: 99%

“…The safety and biocompatibility of microparticulate carriers for dental application has not yet been extensively studied, and very few studies have addressed these issues [91,117,118,120]. Safety assessments include adverse events such as dental infection, headache, tooth sensitivity, dental pain, gingivitis, increased periodontitis, stomatitis, changes in vital signs (blood pressure, temperature or heart rate) or complications associated with over-immune response.…”

Section: Efficacy and Safetymentioning

confidence: 99%

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The Application of Microencapsulation Techniques in the Treatment of Endodontic and Periodontal Diseases

2011

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In the treatment of intracanal and periodontal infections, the local application of antibiotics and other therapeutic agents in the root canal or in periodontal pockets may be a promising approach to achieve sustained drug release, high antimicrobial activity and low systemic side effects. Microparticles made from biodegradable polymers have been reported to be an effective means of delivering antibacterial drugs in endodontic and periodontal therapy. The aim of this review article is to assess recent therapeutic strategies in which biocompatible microparticles are used for effective management of periodontal and endodontic diseases. In vitro and in vivo studies that have investigated the biocompatibility or efficacy of certain microparticle formulations and devices are presented. Future directions in the application of microencapsulation techniques in endodontic and periodontal therapies are discussed.

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“…[89] Various locally delivered antimicrobials have been used aiming at inhibition of the pathogens or modulation of the inflammatory response, which include tetracycline, metronidazole, doxycycline, minocycline, and chlorhexidine. [101112131415]…”

Section: Introductionmentioning

confidence: 99%

Green tea extract as a local drug therapy on periodontitis patients with diabetes mellitus: A randomized case-control study

Gadagi¹,

Chava²,

Reddy³

2013

J Indian Soc Periodontol

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Background:The green tea extract is a naturally occurring product having beneficial effects that counteract with the pathobiological features of periodontitis and diabetes mellitus. Hence, the present study was aimed at incorporation of green tea extract into hydroxylpropyl methylcellulose and investigates its efficacy in chronic periodontitis patients associated with and without diabetes mellitus.Materials and Methods:For the in vitro study, formulation of green tea strips and placebo strips, and analysis of drug release pattern from the green tea strips at different time intervals were performed. For the in vivo study, 50 patients (20-65 years), including 25 systemically healthy patients with chronic periodontitis (group 1) and 25 diabetic patients with chronic periodontitis (group 2) were enrolled. In each patient, test and control sites were identified for the placement of green tea and placebo strips, respectively. Gingival Index (GI), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL) were examined at baseline, first, second, third, and fourth weeks. Microbiological analysis for Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans was performed at baseline and fourth week.Results:The in vitro study showed 10.67% green tea release at 30 min; thereafter, a slow release was noted till 120 min.In vivo study:Both groups showed significant reduction in GI scores at the test sites. Group 1 showed significant (P < 0.001) PPD reduction at different time intervals at the test sites. However, group 2 showed significant reduction from baseline (5.30 ± 0.70) to fourth week (3.5 ± 0.97). Statistically significant gain in CAL at the test sites was observed both in group 1 (1.33 mm) and group 2 (1.43 mm). The prevalence of P. gingivalis in group 1 test sites was significantly reduced from baseline (75%) to fourth week (25%).Conclusions:Local drug delivery using green tea extract could be used as an adjunct in the treatment of chronic periodontitis in diabetic and non-diabetic individuals.

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Comparison of Conventional Periodontal Maintenance Versus Scaling and Root Planing With Subgingival Minocycline

Abstract: Scaling and root planing and subgingival minocycline in experimental sites took little time (<5 minutes/appointment), but resulted in more probing depth reduction and less frequent bone height loss than conventional periodontal maintenance.

Cited by 30 publications

References 31 publications

Comparative Study to Investigate the Effect of Meloxicam or Minocycline HCl In Situ Gel System on Local Treatment of Periodontal Pockets

Comparative Study to Investigate the Effect of Meloxicam or Minocycline HCl In Situ Gel System on Local Treatment of Periodontal Pockets

The Application of Microencapsulation Techniques in the Treatment of Endodontic and Periodontal Diseases

Green tea extract as a local drug therapy on periodontitis patients with diabetes mellitus: A randomized case-control study

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