Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma

She, Dejun; Lu, Yiping; Xiong, Ji; Cao, Dairong; Geng, Daoying; Yin, Bo

doi:10.1177/0284185119845088

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…More importantly, cystic solid masses with moderate to significant enhancement mainly in dorsal and posterior margins were more common in GGs located in the medulla oblongata ( 6 ). While in astrocytomas, the imaging usually showed cystic changes with nodules and enhanced cyst wall and nodules with few calcifications in enhanced scans ( 19 ). Johnson et.al also reported that curved band lesion with low or mixed density and common calcification had few cysts and enhancement, which was usually observed in oligodendroglioma ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Anaplastic ganglioglioma originating from the medulla oblongata: case report

Han¹,

Guan²,

Song³

2021

Transl Cancer Res TCR

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Ganglioglioma (GG) is a rare kind of intracranial tumor with low potential malignancy (WHO grade I), which could occur in any part of the brain. However, a patient with anaplastic ganglioglioma (WHO grade III) in the medulla oblongata is a more peculiar and rare clinical case. In our report, we presented a case of a 45-year-old man with anaplastic ganglioglioma (WHO grade III) in the medulla oblongata, who was perplexed with dysphagia, choking and left-sided numbness for two and a half years. The head magnetic resonance imaging (MRI) showed a 2.7 cm × 2.6 cm lesion in the medulla oblongata with slightly low signal on T1 weighted image (T1WI) and heterogeneous high signal without calcifications on T2 weighted image (T2WI). The Physical Examination manifested that the patient showed a chronic appearance, along with the damage of oculomotor nerve, glossopharyngeal and vagus nerves and spinal thalamus lateral tract and rope body. Subsequently, the patient underwent surgical and common radiotherapy treatment, which might delay the tumor recurrence and contribute to a better overall survival. Unexpectedly, tentative chemotherapy was carried out when the tumor showed the recurrence trend and anaplastic feature. Our presentation of this case would emphasize the rarity and significance of the diagnosis, differentiation and treatment of such tumors, demanding more clinical cases for exploration.

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Section: Discussionmentioning

confidence: 99%

Anaplastic ganglioglioma originating from the medulla oblongata: case report

Han¹,

Guan²,

Song³

2021

Transl Cancer Res TCR

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“…On apparent diffusion coefficient (ADC) map, gangliogliomas have been reported to show a lower ADC value and higher relative cerebral blood volume (rCBV) on dynamic susceptibility contrast imaging than either oligodendrogliomas or pilocytic astrocytomas. 40,41 Gangliogliomas with BRAF p.V600E mutation are reported to have lower ADC values than gangliogliomas without BRAF p.V600E mutation. 42 Imaging spectrums of gangliogliomas in three different patients are shown in Fig.…”

Section: Specific Molecular and Imaging Featuresmentioning

confidence: 99%

The 2021 WHO Classification for Gliomas and Implications on Imaging Diagnosis: Part 3—Summary of Imaging Findings on Glioneuronal and Neuronal Tumors

Park,

Vollmuth,

Foltyn‐Dumitru

et al. 2023

Magnetic Resonance Imaging

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The fifth edition of the World Health Organization classification of central nervous system tumors published in 2021 reflects the current transitional state between traditional classification system based on histopathology and the state‐of‐the‐art molecular diagnostics. This Part 3 Review focuses on the molecular diagnostics and imaging findings of glioneuronal and neuronal tumors. Histological and molecular features in glioneuronal and neuronal tumors often overlap with pediatric‐type diffuse low‐grade gliomas and circumscribed astrocytic gliomas (discussed in the Part 2 Review). Due to this overlap, in several tumor types of glioneuronal and neuronal tumors the diagnosis may be inconclusive with histopathology and genetic alterations, and imaging features may be helpful to distinguish difficult cases. Thus, it is crucial for radiologists to understand the underlying molecular diagnostics as well as imaging findings for application on clinical practice.Evidence Level3Technical EfficacyStage 3

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“…Due to overlap of imaging appearances, differentiating cerebellar GGs from the cerebellar PAs can be challenging [87]. It has been reported that cerebellar GGs have lower relative ADCmin and higher relative CBV than PAs [88].…”

Section: Plgnts Arising From Cerebral Hemispheresmentioning

confidence: 99%

Radiohistogenomics of pediatric low-grade neuroepithelial tumors

2021

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Purpose In addition to histology, genetic alteration is now required to classify many central nervous system (CNS) tumors according to the most recent World Health Organization CNS tumor classification scheme. Although that is still not the case for classifying pediatric low-grade neuroepithelial tumors (PLGNTs), genetic and molecular features are increasingly being used for making treatment decisions. This approach has become a standard clinical practice in many specialized pediatric cancer centers and will likely be more widely practiced in the near future. This paradigm shift in the management of PLGNTs necessitates better understanding of how genetic alterations influence histology and imaging characteristics of individual PLGNT phenotypes. Methods The complex association of genetic alterations with histology, clinical, and imaging of each phenotype of the extremely heterogeneous PLGNT family has been addressed in a holistic approach in this up-to-date review article. A new imaging stratification scheme has been proposed based on tumor morphology, location, histology, and genetics. Imaging characteristics of each PLGNT entity are also depicted in light of histology and genetics. Conclusion This article reviews the association of specific genetic alteration with location, histology, imaging, and prognosis of a specific tumor of the PLGNT family and how that information can be used for better imaging of these tumors.

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Comparison of conventional, diffusion, and perfusion MRI between infratentorial ganglioglioma and pilocytic astrocytoma

Cited by 6 publications

References 25 publications

Anaplastic ganglioglioma originating from the medulla oblongata: case report

Anaplastic ganglioglioma originating from the medulla oblongata: case report

The 2021 WHO Classification for Gliomas and Implications on Imaging Diagnosis: Part 3—Summary of Imaging Findings on Glioneuronal and Neuronal Tumors

Radiohistogenomics of pediatric low-grade neuroepithelial tumors

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