Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery

Choi, Soo Kyoung; Ahn, Dong-Won; Lee, Young-Ho

doi:10.1093/cvr/cvp054

Cited by 32 publications

(38 citation statements)

References 39 publications

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“…Our results also show that afferent arterioles are highly sensitive to S1P compared with the resistance vessels from other vascular beds. [27][28][29] Importantly, in contrast with the effect of S1P in preglomerular microvessels, we found efferent arterioles to be completely unresponsive to S1P. Despite the lack of an efferent arteriole response to S1P, NE vasoconstricted those same efferent arterioles as reported earlier, 35 indicating that these arterioles were capable of responding to vasoconstrictor signals but just were not responsive to S1P.…”

Section: Discussionsupporting

confidence: 57%

“…1,2,5 Recent studies indicate that S1P plays an important role in regulating vascular tone in resistance vessels, including cerebral, coronary, and mesenteric arteries 16,[27][28][29][30][31][32] ; however, very little is known about the renal influence of S1P under either physiologic or pathophysiologic conditions. Bischoff et al reported that S1P vasoconstricted isolated intrarenal arteries 14 and reduced RBF without changing arterial pressure in anesthetized rats, 15 indicating that S1P may be an important regulator of renal vascular function.…”

Section: Discussionmentioning

confidence: 99%

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Sphingosine-1-Phosphate Evokes Unique Segment-Specific Vasoconstriction of the Renal Microvasculature

Guan¹,

Singletary²,

Cook³

et al. 2014

Journal of the American Society of Nephrology

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Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, has been implicated in regulating vascular tone and participating in chronic and acute kidney injury. However, little is known about the role of S1P in the renal microcirculation. Here, we directly assessed the vasoresponsiveness of preglomerular and postglomerular microvascular segments to exogenous S1P using the in vitro blood-perfused juxtamedullary nephron preparation. Superfusion of S1P (0.001-10 mM) evoked concentration-dependent vasoconstriction in preglomerular microvessels, predominantly afferent arterioles. After administration of 10 mM S1P, the diameter of afferent arterioles decreased to 35%65% of the control diameter, whereas the diameters of interlobular and arcuate arteries declined to 50%612% and 68%66% of the control diameter, respectively. Notably, efferent arterioles did not respond to S1P. The S1P receptor agonists FTY720 and FTY720-phosphate and the specific S1P1 receptor agonist SEW2871 each evoked modest afferent arteriolar vasoconstriction. Conversely, S1P2 receptor inhibition with JTE-013 significantly attenuated S1P-mediated afferent arteriolar vasoconstriction. Moreover, blockade of L-type voltage-dependent calcium channels with diltiazem or nifedipine attenuated S1P-mediated vasoconstriction. Intravenous injection of S1P in anesthetized rats reduced renal blood flow dose dependently. Western blotting and immunofluorescence revealed S1P1 and S1P2 receptor expression in isolated preglomerular microvessels and microvascular smooth muscle cells. These data demonstrate that S1P evokes segmentally distinct preglomerular vasoconstriction via activation of S1P1 and/or S1P2 receptors, partially via L-type voltagedependent calcium channels. Accordingly, S1P may have a novel function in regulating afferent arteriolar resistance under physiologic conditions. 25: 177425: -178525: , 201425: . doi: 10.1681 Sphingosine 1-phosphate (S1P) is recognized as an important signaling molecule in diverse biologic processes. 1,2 Growing evidence indicates that S1P plays an important role in regulating vascular reactivity. 3-5 S1P is a bioactive sphingolipid metabolite and is released from erythrocytes, platelets, and endothelial cells. 6,7 The majority of S1P effects are mediated via five distinct receptors (S1P1-S1P5 receptors), which represent a family of small G proteincoupled receptors (GPCRs) 5 ; however, S1P can also exist in the cytoplasm as a second messenger involved in Ca 2+ mobilization or cell survival and proliferation. 8,9 S1P1-S1P3 receptors are expressed by a wide variety of tissues, whereas S1P4 and S1P5 receptors are mainly expressed in cells of the immune and nervous systems. 4,10 In the vasculature, endothelial cells mainly express S1P1 and S1P3 with variable expression of S1P2, whereas vascular smooth muscle cells express S1P2 and S1P3 with variable expression of S1P1. [3][4][5] Studies in animals show that application of exogenous S1P J Am Soc Nephrol

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Sphingosine-1-Phosphate Evokes Unique Segment-Specific Vasoconstriction of the Renal Microvasculature

Guan¹,

Singletary²,

Cook³

et al. 2014

Journal of the American Society of Nephrology

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“…3 ). S1P enhances Ca 2+ mobilization (101)(102)(103)(104)(105) and stimulates the ERK/MAPK pathway to promote cell growth and survival ( 95 ). It may also activate the PI3K/Akt pathway ( 106 ) to affect the balance between pro-and anti-apoptotic Bcl-2 proteins ( 95, 107 ) and activator protein 1 and NF-B, which promote survival ( 108 ).…”

Section: Sphingolipids In the Eyementioning

confidence: 99%

Regulating survival and development in the retina: key roles for simple sphingolipids

Rotstein

Miranda

Abrahan

et al. 2010

Journal of Lipid Research

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tions as structural membrane components and energetic fuels. However, the fi ndings of the previous half century have extended these roles, shedding light on their indisputable relevance as signaling molecules controlling key aspects of cellular life and development. The identifi cation of diacylglycerol and inositol 1,4,5 triphosphate ( 1 ) as second messengers seemed at the time a peculiarity of these lipids. The subsequent fi ndings of the roles of arachidonic acid metabolites ( 2 ), platelet activating factor ( 3 ), and other minor inositol lipids ( 4 ) in cell signaling began to establish that being intracellular messengers was not an oddity but a habitual task for lipids in cells. The family of lipid signaling molecules largely expanded in the last two decades, when several sphingolipids were successively shown to regulate a multiplicity of cell functions. Sphingosine (Sph) was the fi rst sphingolipid to be established as a bioactive lipid, involved in the regulation of protein kinase (PK)C activity ( 5 ). Ceramide (Cer) and sphingosine-1-phosphate (S1P) were next shown to signal a myriad of cell functions and the number of sphingolipid molecules with bioactive properties has gone on enlarging in recent years ( 6, 7 ).Though a vast literature exists on the functions of sphingolipids in several tissues, less is known concerning its roles in the eye, and in the retina in particular. Accumulation of sphingolipids originated in defects in the lysosomal Abstract Many sphingolipids have key functions in the regulation of crucial cellular processes. Ceramide (Cer) and sphingosine (Sph) induce growth arrest and cell death in multiple situations of cellular stress. On the contrary, sphingosine-1-phosphate (S1P), the product of Sph phosphorylation, promotes proliferation, differentiation, and survival in different cell systems. This review summarizes the roles of these simple sphingolipids in different tissues and then analyzes their possible functions in the retina. Alterations in proliferation, neovascularization, differentiation, and cell death are critical in major retina diseases and collective evidence points to a role for sphingolipids in these processes. Cer induces infl ammation and apoptosis in endothelial and retinal pigmented epithelium cells, leading to several retinopathies. S1P can prevent this death but also promotes cell proliferation that might lead to neovascularization and fibrosis. Recent data support Cer and Sph as crucial mediators in the induction of photoreceptor apoptosis in diverse models of oxidative damage and neurodegeneration, and suggest that regulating their metabolism can prevent this death. New evidence proposes a central role for S1P controlling photoreceptor survival and differentiation. Finally, this review discusses the ability of trophic factors to regulate sphingolipid metabolism and transactivate S1P signaling pathways to control survival and development in retina photoreceptors. When asked about the roles of cellular lipids, the fi rst thought usually coming to our minds re...

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“…Sphingosylphosphorylcholine (SPC), a biologically active sphingomyelin metabolite, aug- mented contractile force at pCa 6.3 in β-escin-permeabilized rabbit coronary arteries [12]; a muscarinic agonist induces calcium sensitization in β-escin-permeabilized rat and guinea-pig detrusor smooth muscles [13]; histamine, ET-1 and PDBu induce calcium sensitization in α-toxin-permeabilized rabbit femoral artery [14]; a thromboxane A2 agonist, U46619-induced contraction involves Ca 2＋ entry and calcium sensitization in rat caudal arterial smooth muscle [15]. However, whether NaF induces calcium sensitization is poorly understood.…”

Section: Discussionmentioning

confidence: 99%

“…The relaxing solution containing (in mM) potassium methanesulfonate, 74.1; MgATP, 4.5; EGTA, 1.0; PIPES, 30, and creatine phosphate, 10 were neutralized to pH 7.4 with KOH at 25 o C as previously described [12]. The free Ca 2＋ concentration was calculated using a computer program and expressed as the negative logarithm (pCa).…”

Section: Permeabilization and Tension Recordingmentioning

confidence: 99%

Calcium Sensitization Induced by Sodium Fluoride in Permeabilized Rat Mesenteric Arteries

Yang

Cho

Sohn

et al. 2010

Korean J Physiol Pharmacol

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Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery

Cited by 32 publications

References 39 publications

Sphingosine-1-Phosphate Evokes Unique Segment-Specific Vasoconstriction of the Renal Microvasculature

Sphingosine-1-Phosphate Evokes Unique Segment-Specific Vasoconstriction of the Renal Microvasculature

Regulating survival and development in the retina: key roles for simple sphingolipids

Calcium Sensitization Induced by Sodium Fluoride in Permeabilized Rat Mesenteric Arteries

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