Comparison of continuous sufentanil and fentanyl infusions for outpatient anaesthesia

Phitayakom, Preyaratt; Melnick, Brian M.; Vicinie, A. F.

doi:10.1007/bf03015160

Cited by 19 publications

(5 citation statements)

References 16 publications

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“…Roxane et al in his study found that duration of action of intrathecal fentanyl was 214±120 min and that of sufentanil 240±102 min. 3,4 His findings are comparable to the findings of our study.…”

Section: Discussionsupporting

confidence: 91%

Comparative evaluation of subarachnoid block with low dose bupivacaine and fentanyl versus low dose bupivacaine and sufentanil in patients undergoing inguinal surgeries

Sandeep

Kundurthi

et al. 2019

Int J Clin Trials

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Background: Fentanyl is a phenylpiperidine derivative synthetic opioid agonist. As an analgesic fentanyl is 75-125 times more potent than morphine. Sufentanil is a semisynthetic thienyl analogue fentanyl with analgesic potency 5 to 10 times more than that of fentanyl. Recently there has been an interest in using analgesics and local anaesthetics in an attempt to decrease the local anaesthetic dose enabling faster recovery.Methods: A double blinded randomised study was carried out with 50 patients of ASA grade I and II aged between 20 and 60 years undergoing elective inguinal and below inguinal region surgeries under low dose spinal anaesthesia. Patients received 10 mg of 0.5% hyperbaric bupivacaine with 50 μg of fentanyl added to a total volume of 3 ml (group F), and with sufentanil 5 μg [diluted with 5% dextrose] and volume made to 3 ml (group S). Postoperative VAS score for pain, duration of motor block and complications postoperatively is noted.Results: Prolonged postoperative analgesia was observed in group F (216.7 min) and group S (264.8) which was statistically significant among the groups (p<0.001) is higher in group S and also duration of motor block in group F (130.6) and group S (90.5) which was statistically significant among the groups (p<0.001) which is higher in group F than group S.Conclusions: When compared to intrathecal bupivacaine-fentanyl combination; intrathecal bupivacaine-sufentanil combination provided prolonged postoperative analgesia with a lesser duration of motor blockade thus allowing early post operative ambulation.

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Section: Discussionsupporting

confidence: 91%

Comparative evaluation of subarachnoid block with low dose bupivacaine and fentanyl versus low dose bupivacaine and sufentanil in patients undergoing inguinal surgeries

Sandeep

Kundurthi

et al. 2019

Int J Clin Trials

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“…Phitayakorn et al . [9] compared continuous infusions of fentanyl and sufentanil for outpatient anesthesia and found that intraoperatively administered sufentanil proved to be a better postoperative analgesic than intraoperatively administered fentanyl. Fewer patients in the sufentanil group complained of pain.…”

Section: Discussionmentioning

confidence: 99%

“…[9] compared continuous sufentanil and fentanyl infusions for outpatient anesthesia (D and C) and found that level of consciousness (sedation) was more or less similar in both the groups.…”

Section: Discussionmentioning

confidence: 99%

“…This involves not only a return to near normal preoperative mental and motor functioning but also minimization of uncomfortable side effects such as pain. [9] This necessitates use the of an anesthetic that will have a short duration of action which will ensure early discharge of the patient. This was done using postanesthesia discharge scoring system developed by Aldrete.…”

Section: Discussionmentioning

confidence: 99%

“…Phitayakorn et al . [9] have compared the continuous infusions of fentanyl and sufentanil for outpatient anesthesia. They found significant differences between time to awakening (appropriate response to verbal commands), time to ambulation, and time to discharge home.…”

Section: Discussionmentioning

confidence: 99%

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Conscious sedation for balloon mitral valvotomy: A comparison of fentanyl versus sufentanil

Modak

Kane²

2017

Ann Card Anaesth

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Context:Analgesia and sedation are required for the comfort of patient and the cardiologist during balloon mitral valvotomy.Aims:In this study, efficacy of analgesia, sedation, and patient satisfaction with sufentanil was compared with fentanyl.Settings and Design:Single-centered, prospective single-blind study of sixty patients.Materials and Methods:Patients between 15 and 45 years of rheumatic mitral stenosis with valve area of 0.8–1 cm2 undergoing elective balloon mitral valvotomy, randomly divided to receive bolus injection fentanyl 1 mcg/kg (Group 1, n = 30) followed by infusion at 1 mcg/kg/h or bolus of injection sufentanil 0.1 mcg/kg (Group 2, n = 30) followed by continuous infusion at 0.1 mcg/h. Both the groups received injection midazolam bolus 0.02 mg/kg followed by infusion at 15 mcg/kg/h. Pain intensity (by visual analog score [VAS]), level of sedation (by Ramsay sedation scale), overall patient and operator's satisfaction, effect on cardiorespiratory parameters, and discharge score (by modified Aldrete score) were assessed.Statistical Analysis Used:Statistical analysis used Student's unpaired t-test and Chi-square test. P < 0.05 was considered statistically significant.Results:Mean number of bolus doses in fentanyl group was 0.9 versus 0.13 in sufentanil group (P < 0.01). The mean value of mean blood pressure in fentanyl group was 83.52 mmHg versus 88 mmHg in sufentanil group (P < 0.05), but the value was within normal range in both the groups. The mean VAS – patient's opinion in fentanyl group was 8.97 versus 9.53 in sufentanil group (P < 0.05). Mean discharge score in fentanyl group was 17.87 versus 18.23 in sufentanil group (P < 0.05). No statistically significant difference was found with respect to heart rate, respiratory rate, oxygen saturation, PaCO2 values, and anxiety scores.Conclusion:Sufentanil was found to be better with respect to analgesia, patient satisfaction, and recovery however not cost-effective for continuous infusion technique.

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Zentral wirksame Analgetika vom Typ Opioid

Waldvogel¹

2001

Analgetika Antinozizeptiva Adjuvanzien

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Comparison of continuous sufentanil and fentanyl infusions for outpatient anaesthesia

Cited by 19 publications

References 16 publications

Comparative evaluation of subarachnoid block with low dose bupivacaine and fentanyl versus low dose bupivacaine and sufentanil in patients undergoing inguinal surgeries

Comparative evaluation of subarachnoid block with low dose bupivacaine and fentanyl versus low dose bupivacaine and sufentanil in patients undergoing inguinal surgeries

Conscious sedation for balloon mitral valvotomy: A comparison of fentanyl versus sufentanil

Zentral wirksame Analgetika vom Typ Opioid

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