Comparison of concurrent, sequential, and sandwich chemoradiation modalities in breast cancer therapy: A Meta Analysis

Aryanti, Citra; Sudarsa, Wayan; Manuaba, Tjakra Wibawa

doi:10.1093/annonc/mdz338.054

Cited by 2 publications

(2 citation statements)

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“…It was found that recurrence was higher when chemotherapy was started before radiotherapy than when radiotherapy was initiated rst. Avoiding delay in RT or no maintaining no gap between chemotherapy and RT might lead to their additive interaction and tumor response [23]. Our study found that sandwich RT decreased LRR and improved DFS despite all of the cases having negative margins and node-positive disease.…”

Section: Discussionmentioning

confidence: 64%

Effect of Radiotherapy Sequence on Long-term Outcome in Patients With Node-positive Breast Cancer: a Retrospective Study

Woo

Moon

Kwon

et al. 2021

Preprint

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The optimal sequence of chemotherapy (CT) and radiotherapy (RT) after surgery in breast cancer patients is unclear. There is a lack of literature on RT given between anthracycline and taxane administration. We evaluated the effect of RT sequence on long-term outcome in breast cancer. Two hundred patients who underwent surgery between January 2009 and December 2012 for node-positive breast cancers were evaluated retrospectively. All patients were treated with doxorubicin and cyclophosphamide (AC) followed by taxane. Sandwich RT group that received RT between AC and taxane was compared to the group that received RT after CT. The mean follow-up period was 105.4 months. The locoregional recurrence (LRR) rate was lower in sandwich RT group (P=0.012) and there was no significant difference in distant metastasis between the two groups. The RT sequence was an important predictor for LRR in multivariable analysis (P=0.017). For luminal A subtype, disease-free survival (DFS) was better in sandwich RT group than in CT followed by RT group (P=0.001). The overall survival did not correlated with RT sequence regardless of subtype. Sandwich RT can offer DFS benefit in luminal A subtype breast cancer. A tailored approach of sequencing chemotherapy and radiotherapy would be needed considering the factors that can influence outcome.

show abstract

Section: Discussionmentioning

confidence: 64%

Effect of Radiotherapy Sequence on Long-term Outcome in Patients With Node-positive Breast Cancer: a Retrospective Study

Woo

Moon

Kwon

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…It was found that recurrence was higher when chemotherapy was started before radiotherapy than when radiotherapy was initiated first. Avoiding delay in RT or no maintaining no gap between chemotherapy and RT might lead to their additive interaction and tumor response 25 . Our study found that sandwich RT decreased LRR and improved DFS despite all of the cases having negative margins and node-positive disease.…”

Section: Discussionmentioning

confidence: 99%

Effect of radiotherapy sequence on long-term outcome in patients with node-positive breast cancer: a retrospective study

Woo

Moon

Kwon

et al. 2022

Sci Rep

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The optimal sequence of chemotherapy (CT) and radiotherapy (RT) after surgery in breast cancer patients is unclear. There is a lack of literature on RT given between anthracycline and taxane administration. We evaluated the effect of RT sequence on long-term outcome in breast cancer. Two hundred patients who underwent surgery between January 2009 and December 2012 for node-positive breast cancers were evaluated retrospectively. All patients were treated with doxorubicin and cyclophosphamide (AC) followed by taxane. Sandwich RT group that received RT between AC and taxane was compared to the group that received RT after CT. The mean follow-up period was 105.4 months. The locoregional recurrence (LRR) rate was lower in sandwich RT group (P = 0.012) and there was no significant difference in distant metastasis between the two groups. The RT sequence was an important predictor for LRR in multivariable analysis (P = 0.017). For luminal A subtype, disease-free survival (DFS) was better in sandwich RT group than in CT followed by RT group (P = 0.001). The overall survival did not correlated with RT sequence regardless of subtype. Sandwich RT can offer DFS benefit in luminal A subtype breast cancer. A tailored approach of sequencing chemotherapy and radiotherapy would be needed considering the factors that can influence outcome.

show abstract

Comparison of concurrent, sequential, and sandwich chemoradiation modalities in breast cancer therapy: A Meta Analysis

Cited by 2 publications

References 0 publications

Effect of Radiotherapy Sequence on Long-term Outcome in Patients With Node-positive Breast Cancer: a Retrospective Study

Effect of Radiotherapy Sequence on Long-term Outcome in Patients With Node-positive Breast Cancer: a Retrospective Study

Effect of radiotherapy sequence on long-term outcome in patients with node-positive breast cancer: a retrospective study

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