Comparison of conbercept and ranibizumab combined mitomycin C-augmented trabeculectomy for neovascular glaucoma

Guo, Xiaohong; Wang, Yuwen; Yang, Liangyan; Wang, Pengyun; Chen, Kan; Zhou, Lei; Wu, Yue

doi:10.1007/s10792-021-01846-6

Cited by 7 publications

(8 citation statements)

References 21 publications

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“…One study was by Wittstrom et al (2012) which compared PRP with PRP + IVB and another 2 studies [ 18 ], one by Inatani et al (2021) and another by Yazdani et al (2009), compared sham injection with IVA or IVB, respectively [ 19 , 20 ]. Guo et al (2021) compared Trab + PRP + IVC vs Trab + PRP + IVR [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

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A systematic review and meta-analysis of randomised controlled trials in the management of neovascular glaucoma: absence of consensus and variability in practice

Ramji

Nagi

Ansari

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Purpose Neovascular glaucoma (NVG) is characterised by neovascularisation of the angle and therefore elevated intraocular pressure (IOP). This results in progressive optic neuropathy and loss of visual acuity. Treatment aims to reduce IOP in order to prevent optic nerve damage. A systematic review was completed synthesising results from randomised control trials (RCTs) comparing interventions for the management of NVG and their efficacy and safety. Methods Data was sourced from Web of Science, Embase and Medline after 1st January 2000. The primary outcome measures were mean IOP at follow-up and success rate. The secondary outcomes included mean IOP lowering medications and total complications. A meta-analysis was completed on comparative studies using Revman (version 5.4). Results For the two studies comparing Ahmed glaucoma valve (AGV) + pan-retinal photocoagulation (PRP) vs AGV + PRP + intra-vitreal bevacizumab (IVB), there was no difference in mean IOP or odds of success from the meta-analysis. From the 4 studies examining the utilisation of anti-vascular endothelial growth factor (anti-VEGF), one study showed lower mean IOP at 1 (p = 0.002) and 3 months (p = 0.033) for IVB vs sham injection. In the 2 studies studying transcleral diode laser (TDL), there were no significant findings. From the 4 studies looking at trabeculectomy (trab), lower mean IOP at 6 (p = 0.001), 9 (p = 0.01), 12 (p = 0.02) and 18 months (p = 0.004) was shown for intra-vitreal ranibizumab (IVR) + PRP + visco-trabeculectomy vs IVR + PRP + trab, and a significantly lower mean IOP was present in the Baerveldt group vs trab at 6 months (p = 0.03). In the 2 studies investigating the AGV, there was a lower mean IOP at 1 month (p = 0.01) in the AGV + triamcinolone (TCA) group. The risk of bias was low for 4 studies, high for 4 studies and 6 studies had some concerns. Conclusion This is the first meta-analysis of RCTs in the management of neovascular glaucoma. The lack of high-quality evidence contributes to the lack of consensus in managing NVG. Our results highlight modern treatment strategies and the need for better powered RCTs with long-term follow-up in order to establish optimal treatment modalities and true patient outcomes.

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Section: Resultsmentioning

confidence: 99%

“…Four studies had a low risk of bias [ 16 , 19 , 20 , 27 ]. From the remaining 10 studies, 6 had some concerns [ 17 , 18 , 21 , 23 , 26 , 28 ] and 4 had a high risk of bias [ 22 , 24 , 25 , 29 ] (Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of randomised controlled trials in the management of neovascular glaucoma: absence of consensus and variability in practice

Ramji

Nagi

Ansari

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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“…Trabeculectomy is the gold standard surgical treatment in patients with glaucoma. This surgery aims to reduce intraocular pressure by creating a stula between the subconjunctival area and the anterior chamber [13,14]. The Ahmed glaucoma valve is a drainage device that uses a venturi valve mechanism to control excessive aqueous drainage into the posterior episcleral or subconjunctival area.…”

Section: Discussionmentioning

confidence: 99%

Effect of the covid-19 pandemic on progression to glaucoma surgery in patients followed up in a retina unit

Gedik,

Erol,

Duman

et al. 2023

ret.vit

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IntroductionIn this study, we aimed to investigate the effect of the COVID-19 on progression to glaucoma surgery in patients followed up at the retina unit of the Ophthalmology Outpatient Clinic of Health Sciences University Antalya Training and Research Hospital. MethodsThe patients who were followed up at the retina unit of our hospital. The patients were divided into four groups. This study was retrospective. ResultsThe ratio of the number of patients who underwent glaucoma surgery to the number of those presenting to the retina unit was found to be statistically signi cantly increased in Group 4 compared to the remaining three groups (p<0.0001 for all). The ratio of the number of patients who were followed up in the retina unit and underwent surgery due to neovascular or silicone oil-induced glaucoma to the total number of patients who presented to the retina unit was statistically signi cantly increased in Group 4 compared to Groups 1 and 2 (p=0.001 for both). ConclusionThis study is the rst to examine the effect of the COVID-19 pandemic on progression to glaucoma surgery in patients followed up at the retina unit. We found an increase in the number of patients that required surgery for neovascular or silicone oil-induced glaucoma compared to previous years as a result of not attending regular follow-up at the retina unit due to COVID-19. We consider that inability to apply timely treatments due to the pandemic conditions are effective in this situation.

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Section: Discussionmentioning

confidence: 99%

Effect of the Covid-19 Pandemic on Progression to Glaucoma Surgery in Patients Followed Up in a Retina Unit

Gedık

Erol

Duman

et al. 2022

Preprint

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IntroductionIn this study, we aimed to investigate the effect of the COVID-19 on progression to glaucoma surgery in patients followed up at the retina unit of the Ophthalmology Outpatient Clinic of Health Sciences University Antalya Training and Research Hospital.MethodsThe patients who were followed up at the retina unit of our hospital. The patients were divided into four groups. This study was retrospective.Results The ratio of the number of patients who underwent glaucoma surgery to the number of those presenting to the retina unit was found to be statistically significantly increased in Group 4 compared to the remaining three groups (p<0.0001 for all). The ratio of the number of patients who were followed up in the retina unit and underwent surgery due to neovascular or silicone oil-induced glaucoma to the total number of patients who presented to the retina unit was statistically significantly increased in Group 4 compared to Groups 1 and 2 (p=0.001 for both). ConclusionThis study is the first to examine the effect of the COVID-19 pandemic on progression to glaucoma surgery in patients followed up at the retina unit. We found an increase in the number of patients that required surgery for neovascular or silicone oil-induced glaucoma compared to previous years as a result of not attending regular follow-up at the retina unit due to COVID-19. We consider that inability to apply timely treatments due to the pandemic conditions are effective in this situation.

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Comparison of conbercept and ranibizumab combined mitomycin C-augmented trabeculectomy for neovascular glaucoma

Cited by 7 publications

References 21 publications

A systematic review and meta-analysis of randomised controlled trials in the management of neovascular glaucoma: absence of consensus and variability in practice

A systematic review and meta-analysis of randomised controlled trials in the management of neovascular glaucoma: absence of consensus and variability in practice

Effect of the covid-19 pandemic on progression to glaucoma surgery in patients followed up in a retina unit

Effect of the Covid-19 Pandemic on Progression to Glaucoma Surgery in Patients Followed Up in a Retina Unit

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