Comparison of Combined and Aerobic Training on ABCG1 Lymphocyte Gene Expression in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting

Abstract

Background and objectives: Cardiovascular disease is one of the most important causes of mortality worldwide. The present study aimed to compare two different cardiac rehabilitation protocols on ATP-binding cassette sub-family G member 1 (ABCG1) lymphocyte expression and blood lipid profile in middle-aged men undergoing coronary artery bypass grafting.Methods: Forty five middle-aged men who had previously undergone coronary artery bypass surgery were randomly divided into three groups of control (C; n=15), aerobic training (AT; n=15) and combined training (CT; n=15). Blood samples were taken before the first and after the last exercise sessions. After isolation of mononuclear cells using Ficoll and mRNA purification, gene expression changes were examined by real-time PCR. Data were analyzed using one-way ANOVA and Bonferroni post-hoc tests.Results: Eight weeks of training intervention resulted in a significant increase in ABCG1 expression as well as a significant decrease in plasma levels of LDL, triglyceride and total cholesterol in both training groups. However, there was no significant difference between the AT and CT groups. In addition, high-density lipoprotein was significantly increased in the AT and CT groups.Conclusion: Both AT and CT can increase plasma LDL and increase ABCG1 expression and HDL concentrations, indicating the positive effects of both interventions on the prevention of atherosclerosis.

Comparing the Effect of Eight Weeks of Aerobic and Combined Exercise on Some Hemorheological Indicators in Middle-Aged Male Patients Undergoing Coronary Artery Bypass Graft Surgery

“…Subjects in the aerobic and combined exercise groups participated in an eight-week training program based on the recommendations of the American College of Sports Medicine (13).…”

“…In addition to the amount of fatigue and cardiac symptoms, the duration and intensity of exercise were adjusted at 60% of the maximum heart rate. The intensity and duration of exercise gradually increased based on patients' ability to reach 80% of their maximum heart rate in the last two sessions (13,14).…”