Comparison of clinicopathological features between children and adults with IgA nephropathy

Wang, Tianzhen; Ye, Fei; Meng, Hongxue; Zhang, Lei; Jin, Xiaoming

doi:10.1007/s00467-012-2139-3

Cited by 20 publications

(19 citation statements)

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“…This value was lower than that of 3.32 determined for adult IgAN Chinese patients [24] and lower than that of ≥ 4.5 for adult IgAN Japanese patients reported by Komatsu et al [11]. Specificity and sensitivity in our tests were not particularly high but nevertheless were statistically significant.…”

Section: Discussioncontrasting

confidence: 60%

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Relationship between serum IgA/C3 ratio and severity of histological lesions using the Oxford classification in children with IgA nephropathy

et al. 2014

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Section: Discussioncontrasting

confidence: 60%

“…P<0.05, MEST score 0 vs. MEST score ≥ 3 of biochemical tests: on average, 1.35±2.2 years (median 0.5 years, range 0.08-13 years) but being shorter though not significantly so in group A (nephrotic-range proteinuria). In Japanese and Chinese studies, this period was also~1 year [8,24].…”

Section: Discussionmentioning

confidence: 97%

Relationship between serum IgA/C3 ratio and severity of histological lesions using the Oxford classification in children with IgA nephropathy

et al. 2014

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“…2 In children, the male-female ratio is similar (about 1.6:1). 3 Although there are clear geographical and ethnic variances, IgAN is more common in Asians. IgAN was diagnosed in 40% of native-kidney biopsies in Asia, compared with 20% in Europe, 5-10% in the United States and less than 5% in Central Africa.…”

Section: Introductionmentioning

confidence: 99%

“…IgAN is frequently detected among adolescents and young adults and the male‐to‐female ratio varies from 2:1 to 3:1 . In children, the male‐female ratio is similar (about 1.6:1) . Although there are clear geographical and ethnic variances, IgAN is more common in Asians.…”

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confidence: 99%

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Immunoglobulin a nephropathy: Pathological markers of renal survival in paediatric patients

et al. 2016

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IgA nephropathy (IgAN) is one of the leading causes of glomerulonephritis characterized by the findings of IgA and IgG immune deposits in the mesangium of kidney biopsies from patients with persistent microscopic haematuria. IgAN is frequently detected among adolescents and young adults. IgAN presents a highly variable course that includes a spectrum from a very mild disease to end‐stage renal disease (ESRD). There are several clinical and histological factors that strongly determined the final outcome of patients with IgAN. Pathological variables associated with unfavorable outcomes are mesangial hypercellularity, segmental glomerulosclerosis, endocapillary hypercellularity and interstitial fibrosis/tubular atrophy, according to the Oxford classification. Moreover, some studies also suggest a role for complement activation in the pathogenesis of IgAN. In this regard, staining for C4d may be an independent risk factor for the development of ESRD in IgAN. Despite the growing number of studies assessing IgAN risk factors, this kind of investigation in paediatric patients is still very limited. The aim of this article is to revise pathological markers related to deterioration of renal function in paediatric patients with IgAN, particularly those that can independently affect renal survival.

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IgA Nephropathy in Children: A Multicenter Study in Poland

Mizerska-Wasiak

Turczyn

Such

et al. 2016

Advancements in Clinical Research

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IgA nephropathy (IgAN) is the most common form of glomerulonephritis in pediatric population. The clinical presentation of the disease in children ranges from microscopic hematuria to end-stage kidney disease. The aim of the study was to retrospectively assess clinical and kidney biopsy features in children with IgAN. We assessed a cohort of 140 children, 88 boys, 52 girls with the diagnosis of IgAN in the period of 2000-2015, entered into the national Polish pediatric IgAN registry. The assessment included the following: proteinuria, hematuria, glomerular filtration rate (GFR), arterial blood pressure, and the renal pathological changes according to the Oxford classification and crescents formation, as modifiable and unmodifiable risk factors. The incidence of IgAN in Poland was set at 9.3 new cases per year. The mean age at onset of IgAN was 11.9 ± 4.3 years, and the most common presentation of the disease was the nephritic syndrome, recognized in 52 % of patients. Kidney biopsy was performed, on average, 1.3 ± 2.0 years after onset of disease. Based on the ROC analysis, a cut-off age at onset of disease for GFR <90 mL/min/1.73 m (risk factor of progression) was calculated as 13.9 years. Unmodifiable lesions: segmental sclerosis, tubular atrophy/interstitial fibrosis (S1, T1-2) in the Oxford classification and crescents in kidney biopsy were significantly more common in Gr 1 (>13.9 years) compared with Gr 2 (<13.9 years), despite a significantly shorter time to kidney biopsy in the former. We conclude that IgAN in children may be an insidious disease. A regular urine analysis, especially after respiratory tract infections, seems the best way for an early detection of the disease.

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Comparison of clinicopathological features between children and adults with IgA nephropathy

Abstract: Pediatric patients showed relatively mild clinical manifestations and histological lesions compared with adult patients. URI was the most important trigger for IgAN, particularly in children. IgAN associated with URI was relatively mild.

Cited by 20 publications

References 31 publications

Relationship between serum IgA/C3 ratio and severity of histological lesions using the Oxford classification in children with IgA nephropathy

Relationship between serum IgA/C3 ratio and severity of histological lesions using the Oxford classification in children with IgA nephropathy

Immunoglobulin a nephropathy: Pathological markers of renal survival in paediatric patients

IgA Nephropathy in Children: A Multicenter Study in Poland

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