Comparison of Clinical Usefulness of Enoxacin (ENX, AT-2266) and Pipemidic Acid (PPA) in the Treatment of Acute Infectious Diarrhea by a Double-Blind Method

Abstract

The clinical usefulness of Enoxacin (ENX, AT-2266), a new oral antibacterial agent, was compared with that of pipemidic acid (PPA) in the treatment of acute infectious diarrhea (bacillary dysentery, Campylobacter enteritis and enteropathogenic and enterotoxigenic E. coli enteritis) by a double-blind method.Daily dosage of ENX and PPA was 600 mg and 2000 mg, respectively. The duration of the treatment was 5 days. Of 242 cases treated, various statistical analyses were carried out in 146 cases,and 96 cases were excluded.Of 146 cases, 73 cases were treated with ENX or PPA respectively. There was no statistical significance between ENX group and PPA group in terms of the background characteristics and MIC distribution against each drug.The results obtained were as follows.