Comparison of Clinical, Ultrasonographic, and Biochemical Differences at the Beginning of Puberty in Healthy Girls Born Either Small for Gestational Age or Appropriate for Gestational Age: Preliminary Results

Hernández, María Isabel; Martínez, A.; Capurro, T.; Peña, Verónica; Trejo, León; Ávila, Alejandra; Salazar, Teresa; Asenjo, Sylvia; Íñiguez, Germán; Mericq, Verónica

doi:10.1210/jc.2005-2368

Cited by 41 publications

(23 citation statements)

References 42 publications

(27 reference statements)

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“…In our cohort, by design, we did not include small-for-gestational-age infants, but we observed that those born with a birth weight <3 kg or with a birth length <48 cm had no increased risk of high DHEAS at 7 years. Our findings are in line with our own experience in early pubertal girls of low birth weight gain and with other groups which have not demonstrated this association [7,[34][35][36] .…”

Section: Discussionsupporting

confidence: 93%

Early BMI Gain and Later Height Growth Predicts Higher DHEAS Concentrations in 7-Year-Old Chilean Children

Mericq

Pereira²,

Uauy³

2016

Horm Res Paediatr

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Background: Accelerated weight and height gain in infancy have been associated with premature adrenarche. However, the exact tempo of these events remains undefined. Thus, our goal wasto assess the relationship between early BMI and height growth in different periods before 7 years of age and plasma DHEAS levels at 7 years of age. Methods: This is a longitudinal follow-up of participants of the Growth and Obesity Chilean Cohort Study (GOCS) that represents Chilean children from low- to middle-income families. The subjects were 972 children (48% girls) with birth weights of 2,500-4,500 g for whom serial weight and height measurements from birth until 7 years were available. At 7 years of age, we also measured DHEAS, IGF-I, leptin, insulin, and other metabolic markers in serum. The main outcome of interest was plasma DHEAS concentrations at 7 years of age. Results: At 7 years of age, children with DHEAS >75th percentile of the sample were taller and fatter and presented higher HOMA-IR and IGF-I than their counterparts (p < 0.05). Children with higher DHEAS were heavier at 4 years of age and beyond compared to their counterparts (higher BMI [BMI SDS at 4 years: 1.16, 95% CI 1.02-1.29 vs. 0.83, 95% CI 0.76-0.91, p < 0.001]) and taller at 7 years of age (height SDS at 7 years: 0.19, 95% CI -0.08 to 0.31 vs. -0.001, 95% CI -0.06 to 0.06, p < 0.005). Conclusions: We observed weight and BMI from 2 to 4 years, and height gains from 4 to 7 years were associated with higher DHEAS levels at 7 years.

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Section: Discussionsupporting

confidence: 93%

Early BMI Gain and Later Height Growth Predicts Higher DHEAS Concentrations in 7-Year-Old Chilean Children

Mericq

Pereira²,

Uauy³

2016

Horm Res Paediatr

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“…Discordant findings were reported by a Chilean group: at the beginning of puberty (Tanner stage 2 of breast development), SGA girls with BMI between 10th and 95th percentiles had higher basal and GnRH-stimulated estradiol levels compared with AGA girls, whereas basal FSH and LH concentrations were similar in SGA and AGA children; 2 years later, FSH concentration was lower, but GnRH-stimulated LH and basal estradiol levels were higher in SGA children compared with AGA. Authors suggest that these differences may allow faster transition through puberty in SGA girls [7,41]. …”

Section: Patterns Of Puberty In Children Born Sgamentioning

confidence: 99%

“…Hernandez et al [41] reported divergent results. At the beginning of puberty, SGA girls had slightly larger uterine size, ovarian volume and number of follicles compared to AGA girls.…”

Section: Gonadal Morphology and Fertilitymentioning

confidence: 99%

Puberty in Children Born Small for Gestational Age

Verkauskienė

Petraitienė²,

Wikland³

2013

Horm Res Paediatr

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Small for gestational age (SGA) children are more prone to have precocious pubarche and exaggerated precocious adrenarche, an earlier onset of pubertal development and menarche, and faster progression of puberty than children born of appropriate for gestational age (AGA) size. The majority of studies investigating the onset of puberty in children born SGA and AGA established that, although puberty begins at an appropriate time (based on chronological age and actual height) in SGA children, onset is earlier relative to AGA children. Evaluating pubertal growth in SGA children, a more modest bone age delay from chronological age at the onset of puberty and more rapid bone maturation during puberty compared to AGA children were reported. Peak height velocity in adolescence is reached at an earlier pubertal stage and lasts for a shorter period in children born SGA than in those born AGA. These differences lead to an earlier fusion of the growth plates and a shorter adult height. The pathophysiological mechanism underlying the unique pubertal growth pattern of children born SGA remains unclear. However, it seems that this is not only related to birth weight, gestational age, adiposity or obesity, but that there may also be an influence of rapid weight gain in early childhood on pubertal onset: excess weight gain in childhood may be related to central adiposity, decreased insulin sensitivity, and increased IGF-I levels and might thus predispose to precocious pubarche.

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“…In women born SGA, smaller ovaries and uterus and lower anti-Mullerian hormone levels -a marker of follicle pool size -have been described (Ibanez et al, 2003). These findings could not be replicated by others (Hernandez et al, 2006;Jensen et al, 2007). In a large cohort, it was recently shown that being born SGA does not have a negative effect on gonadal function in adult men.…”

Section: Puberty In Short Children Born Small For Gestational Agementioning

confidence: 97%

GH-IGF-IGFBP Axis and Metabolic Profile in Short Children Born Small for Gestational Age

Kaay¹,

Hokken-Koelega²

2011

Update on Mechanisms of Hormone Action - Focus on Metabolism, Growth and Reproduction

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Comparison of Clinical, Ultrasonographic, and Biochemical Differences at the Beginning of Puberty in Healthy Girls Born Either Small for Gestational Age or Appropriate for Gestational Age: Preliminary Results

Cited by 41 publications

References 42 publications

Early BMI Gain and Later Height Growth Predicts Higher DHEAS Concentrations in 7-Year-Old Chilean Children

Early BMI Gain and Later Height Growth Predicts Higher DHEAS Concentrations in 7-Year-Old Chilean Children

Puberty in Children Born Small for Gestational Age

GH-IGF-IGFBP Axis and Metabolic Profile in Short Children Born Small for Gestational Age

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