Comparison of clinical symptoms after Helicobacter pylori eradication in functional dyspepsia patients based on endoscopic view of antral gastropathy

Abstract

Functional dyspepsia is a common gastric disease that can be associated with Helicobacter pylori infection. The aim of this study is to evaluate antral endoscopy of individuals who presented with functional dyspepsia, H. pylori infection status and the effects of eradication therapy on the symptoms. Following the diagnosis of dyspepsia as per Rome III criteria, 260 individuals who were eligible for the study underwent upper gastrointestinal endoscopy and were divided into four groups of 65 according to the endoscopic view, grades I, II, III and IV (negative). Stool antigen test was also performed for all patients to identify H. pylori infection. The early signs of dyspepsia were assessed by a standard questionnaire. In all groups, omeprazole, amoxicillin, clarithromycin and metronidazole were used for eradication treatment, and 1 month after the treatment, a faecal antigen test was repeated to evaluate the eradication of H. pylori . There was no statistically significant difference between the groups in terms of clinical symptoms before treatment. The highest response to eradication treatment was seen in individuals with antral gastropathy grade III (66.2%) and the lowest response was in patients without antral gastropathy Grade IV (32.3%). This difference was statistically significant. There was no statistically significant relationship between the participants in terms of family history, age, gender and response to treatment. Eradicating H. pylori reduces the symptoms of dyspepsia. The response of eradication therapy was greatest among the patients with grade III antral gastropathy.

Development of an easy-to-use urease kit for detecting Helicobacter pylori in canine gastric mucosa

“…The ure C gene copy number was used to determine the number of H. pylori in biopsy samples, which were positive at a copy number of 4.78×10 9 and produced a Cq value of 11.64. When a dog with a history of chronic vomiting was tested histopathologically, it was found that it had symptoms of chronic enteritis duodenitis H. pylori infection alters acids in the duodenum, produces abnormal duodenal movement that cause chronic enteritis, and leads to manifestations of ulcerative colitis [ 17 , 18 ].…”

Future Nanotechnology‐Based Strategies for Improved Management of Helicobacter pylori Infection

“…The clinical diagnosis of H. pylori infection is conventionally performed by tests, such as the rapid urease test (RUT), [ 146,147 ] serological tests, [ 148,149 ] invasive endoscopy, [ 150,151 ] and stool antigen test (SAT). [ 152,153 ] However, some drawbacks of these tests have been reported, such as limitations in young children and pregnant women (related to UBT: 14 C‐urea breath test), [ 154,155 ] low sensitivity and acceptability (related to serum antibody test and invasive endoscopy), [ 156 ] appearance of false negative results in low bacterial infections (related to SAT).…”

Sleep quality in functional dyspepsia patients: A cross-sectional study from a tertiary care hospital in Karachi.

“…Dyspepsia accounts for 40% of visits to gastrointestinal clinics, making it one of the most common causes for referrals. 1 Quite possibly of the most common functional gastrointestinal problem (FGIDs), functional dyspepsia (FD), is described by upper stomach distress and/ or distress without organic abnormalities. The epigastric pain syndrome and postprandial distress syndrome subsets of FD were separated by the Rome IV Consensus.…”