Comparison of clinical presentation of respiratory tract infections in H1N1/09-positive and H1N1/09-negative patients

Abstract

Clinical signs cannot reliably differentiate H1N1/09-positive and H1N1/09-negative patients, although we found a higher proportion of myalgias in H1N1/09-positive patients. Severity of disease was lower in H1N1/09-positive than in H1N1/09-negative patients, mostly because of a higher proportion of asthma/wheezing episodes among H1N1/09-negative patients.

Identification of children at risk of influenza-related complications in primary and ambulatory care: a systematic review and meta-analysis

“…Definitions of underlying conditions were consistent within studies, but varied between studies. Among 12 studies which considered immunosuppression as a potential risk factor, seven defined cancer, 35 haematological conditions, 22,24,25,36 or sickle cell disease 37,38 as additional separate conditions. Four studies did not consider these conditions separately from immunosuppression.…”

ABCB1 Polymorphisms and Neuropsychiatric Adverse Events in Oseltamivir-Treated Children During Influenza H1N1/09 Pandemia

“…A total of 109 patients were enrolled in the cohort study [16], from which our study was a part of (median age of 7.02 years old, interquartile range…”

“…Our study was part of a larger study, which concerned 109 patients during the H1N1 pandemia and aimed to compare the clinical presentation of febrile respiratory tract infections in H1N1/09 positive and negative patients [16]. The primary objective of our study was to examine the safety profile of oseltamivir in the pediatric population, with a focus on NPAE.…”

Influenza burden, prevention, and treatment in asthma‐A scoping review by the EAACI Influenza in asthma task force

“…Asthma represented a risk factor for hospitalization during influenza seasons in the general population, with an OR of 2.6 (95% CI 1.6‐4.0) in 2 Canadian studies, and a relative risk (RR) of 4.47 (95% CI 1.49‐13.39) in Israel . The same applied to children, where asthma conferred a 4‐fold risk of hospitalization (the United States, Germany, and Argentina), with a 21‐fold risk observed in South Korea . Interestingly, influenza‐related hospitalization costs in children with asthma may be lower than in children with other chronic conditions and were very close to costs in children without comorbidity …”