Comparison of clinical presentation and incidence of cardiopulmonary complications between male and female Thai patients with early systemic sclerosis: inception cohort study

Wangkaew, Suparaporn; Tungteerabunditkul, S.; Prasertwittayakij, Narawudt; Euathrongchit, Juntima

doi:10.1007/s10067-019-04551-z

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…A referral bias may cause a high frequency of anti-Scl-70 antibodies. However, it was similar to that described in the Northern (79%) 29 and the North-Eastern (81%) 28 Thai series. Anyway, all of these centers were the SSc referral centers.…”

Section: Discussionsupporting

confidence: 87%

“…However, the SSc patients included in the immediately aforementioned studies had a longer disease duration (>6 years) and they lived in a subtropical area. Foocharoen et al 28 and Wangkaew et al 29 (overlapped population with Wangkaew et al 7 ) from another two Thailand SSc referral centers reported prevalence rates of DU of 19% and 8.7%. These series had a longer disease duration (>8 years).…”

Section: Discussionmentioning

confidence: 97%

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Prevalence of and factors independently associated with digital ischemic complications in patients with systemic sclerosis

Guayboon

Muangchan

2022

Journal of Scleroderma and Related Disorders

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Objective: To investigate the prevalence of and independent predictors for digital ischemic complications in patients with systemic sclerosis. Method: Patients enrolled in the Siriraj Systemic Sclerosis Cohort registry during 2013–2019 were classified as having or not having digital ischemic complications at the baseline and 1-year timepoints. Results: A total of 171 patients with systemic sclerosis were included. The prevalence of digital pulp loss, digital pitting scar, digital ulcer, and digital amputation at baseline and 1 year was 41.5%, 39.8%, 3.5%, 7.6% and 37.4%, 43.9%, 14.1%, 6.4%, respectively. Over half (58.5%) of overall systemic sclerosis had developed new digital ischemic complications during the 1-year follow-up. Those with digital ischemic complications at baseline were at high risk for developing new digital ischemic complications (odds ratio: 15.9). Diffuse cutaneous systemic sclerosis is associated with digital ischemic complications (odds ratio: 6.0), digital pitting scar (odds ratio: 4.9), and digital pulp loss (odds ratio: 6.4). Tendon friction rub is associated with digital pitting scar (odds ratio: 5.0). Salt-and-pepper skin appearance is associated with digital pulp loss (odds ratio: 3.0) and digital ulcer (odds ratio: 6.9). Disease duration > 3 years is associated with digital ulcer (odds ratio: 4.4). Male gender is associated with digital ulcer (odds ratio: 5.4). Conclusion: Digital pulp loss, digital pitting scar, digital ulcer, and digital amputation were common manifestations of digital ischemic complications, and diffuse cutaneous systemic sclerosis was the strongest of the six independent predictors.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 97%

Prevalence of and factors independently associated with digital ischemic complications in patients with systemic sclerosis

Guayboon

Muangchan

2022

Journal of Scleroderma and Related Disorders

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“…At enrolment, in the SSc-CM group, there was a higher prevalence of the male gender, DcSSc subtype, and anti-topoisomerase I antibody-positive. Men were found to have higher incidence of right ventricular dysfunction, ILD and more severe disease manifestations compared to women, in our prior published inception cohort data 37 . There was also more suggestive evidence of severe clinical presentation in the SSc-CM including small joint contracture, dysphagia; higher values of mRSS, CK level, and Pro-BNP level; lower values of oxygen saturation than the non-CM subgroup; and more severe left ventricular abnormalities than those with non-CM.…”

Section: Discussionmentioning

confidence: 66%

Predictors and survival of cardiomyopathy determined by echocardiography in Thai patients with early systemic sclerosis: an inception cohort study

Wangkaew

Prasertwitayakij

Intum

et al. 2023

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Available data including the incidence, predictors and long-term outcome of early systemic sclerosis patients associated with suspected cardiomyopathy(SSc-CM) is limited. Therefore, we aimed to study the incidence, predictors and survival of SSc-CM. An inception cohort study was conducted for early SSc patients seen at the Rheumatology Clinic, Maharaj Nakorn Chiang Mai Hospital, Thailand, from January 2010 to December 2019. All patients were determined for clinical manifestations and underwent echocardiography and HRCT at enrollment and then annually. SSc-CM was determined and classified using echocardiography. 135 early SSc patients (82 female,108 DcSSc) were enrolled. With the mean follow-up period of 6.4 years, 32 patients developed SSc-CM. The incidence of SSc-CM was 5.3 per 100-person years. The multivariate Cox regression analysis showed that baseline anti-topoisomerase I-positive (Hazard ratio[HR] 4.86, p = 0.036), dysphagia (HR 3.35, p = 0.001), CK level ≥ 500 U/L(HR 2.27, p = 0.045) and low oxygen saturation (HR 0.82, p = 0.005) were predictors of SSc-CM. The survival rates after SSc-CM diagnosis at 1, 5 and 10 years were 90.3%, 73.1%, and 56.1%, respectively. In this study cohort, the incidence of SSc-CM was 5.3 per 100-person years, and tended to have low survival. The presence of anti-topoisomerase I antibody, dysphagia, CK level ≥ 500 U/L, and low oxygen saturation were independent baseline predictors for developing SSc-CM.

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“…Finally, a smaller Asian cohort study in Thailand ( n = 115; 46 males) by Wangkaew et al 8 compared male and female adult SSc patients with early disease onset, with similar age of onset and disease duration between sexes, eliminating some of these potential biases. At the last visit, male patients had a higher prevalence of active digital ulceration, interstitial lung disease, joint contracture, and tendon friction rub; these were also observed in our cohort at enrollment, some significantly, while others trending.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 Although adult males are less frequently affected, they have a difference in SSc organ manifestations and demonstrate a more severe disease course in cohort studies. [4][5][6][7][8][9] To address if these or other differences are present in jSSc patients we reviewed our patients' data enrolled in the juvenile systemic sclerosis inception cohort (jSScC) at their baseline visit and after 12 months regarding organ involvement and disease severity, including physician and patientreported outcomes, between male and female sex.…”

Section: Introductionmentioning

confidence: 99%

Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort

Foeldvari

Kasapçopur

Adroviç

et al. 2022

Journal of Scleroderma and Related Disorders

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Objective: To compare organ involvement and disease severity between male and female patients with juvenile onset systemic sclerosis. Methods: Demographics, organ involvement, laboratory evaluation, patient-reported outcomes and physician assessment variables were compared between male and female juvenile onset systemic sclerosis patients enrolled in the prospective international juvenile systemic sclerosis cohort at their baseline visit and after 12 months. Results: One hundred and seventy-five juvenile onset systemic sclerosis patients were evaluated, 142 females and 33 males. Race, age of onset, disease duration, and disease subtypes (70% diffuse cutaneous) were similar between males and females. Active digital ulceration, very low body mass index, and tendon friction rubs were significantly more frequent in males. Physician global assessment of disease severity and digital ulcer activity was significantly higher in males. Composite pulmonary involvement was also more frequent in males, though not statistically significantly. After 12 months, they are the pattern of differences changed female patients had significantly more frequent pulmonary involvement. Conclusion: In this cohort, juvenile onset systemic sclerosis had a more severe course in males at baseline and but the pattern changed after 12 months. Some differences from adult findings persisted, there is no increased signal of pulmonary arterial hypertension or heart failure in male pediatric patients. While monitoring protocols of organ involvement in juvenile onset systemic sclerosis need to be identical for males and females.

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Comparison of clinical presentation and incidence of cardiopulmonary complications between male and female Thai patients with early systemic sclerosis: inception cohort study

Cited by 11 publications

References 19 publications

Prevalence of and factors independently associated with digital ischemic complications in patients with systemic sclerosis

Prevalence of and factors independently associated with digital ischemic complications in patients with systemic sclerosis

Predictors and survival of cardiomyopathy determined by echocardiography in Thai patients with early systemic sclerosis: an inception cohort study

Gender differences in juvenile systemic sclerosis patients: Results from the international juvenile scleroderma inception cohort

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