Comparison of clinical prediction scores for the diagnosis of deep vein thrombosis in unselected population of outpatients and inpatients

Sermsathanasawadi, Nuttawut; Suparatchatpun, P; Pumpuang, T; Hongku, Kiattisak; Chinsakchai, Khamin; Wongwanit, Chumpol; Ruangsetakit, Chanean; Mutirangura, Pramook

doi:10.1177/0268355514541981

Cited by 7 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most practical clinical method used to determine the likelihood of DVT is the Wells scoring system (1,(48)(49)(50)(51)(52) The details of this system are presented in Table 2. However, the guidelines and reports in the present articles do not consider the Wells scoring system to be a reliable test for pregnant women.…”

Section: Wells Scoring Systemmentioning

confidence: 99%

Deep Vein Thrombosis in Pregnancy: A Review Article

et al. 2020

View full text Add to dashboard Cite

Background and Aim: To date, numerous studies have evaluated the risk factors and treatment of venous thromboembolism (VTE) during pregnancy. The present study aimed to compile and present the latest guidelines related to the management and diagnosis of deep vein thrombosis (DVT) in pregnant women. Materials and Methods: In the present study, around 100 articles indexed from 2000 were retrieved from local and international databases using keywords, including "pregnancy", "DVT", "VTE", "anticoagulation", and "coagulopathy". Results: The current study examined the pathophysiology of DVT in pregnancy, risk factors, clinical signs, diagnosis, and treatment of DVT in pregnancy. Conclusion: Women during pregnancy and postpartum period represent one of the highest risk groups for DVT. The treatment and supportive measures are of paramount importance to reduce the risk and complications of this disease. Nonetheless, they are not devoid of serious challenges since the possible complications which can occur to the fetus and maternal health during pregnancy should be taken into account in treatment.

show abstract

Section: Wells Scoring Systemmentioning

confidence: 99%

Deep Vein Thrombosis in Pregnancy: A Review Article

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Similar findings have been published by other groups. 18 Sermsathanasawadi et al 72 applied and compared five different clinical scores (Wells, modified Wells, Kahn, St Andre and Constans scores) on 500 consecutive outpatients and inpatients. They showed that modified Wells score and Constans score were more accurate for unselected outpatients and inpatients (based upon AUC-ROC), but they had poor prediction values for inpatients (AUC-ROC: 0.59-0.60).…”

Section: Inpatients Outpatients and Primary Care Patientsmentioning

confidence: 99%

A systematic review of clinical prediction scores for deep vein thrombosis

et al. 2016

View full text Add to dashboard Cite

Objective Diagnosis of deep vein thrombosis remains a challenging problem. Various clinical prediction rules have been developed in order to improve diagnosis and decision making in relation to deep vein thrombosis. The purpose of this review is to summarise the available clinical scores and describe their applicability and limitations. Methods A systematic search of PubMed, MEDLINE and EMBASE databases was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance using the keywords: clinical score, clinical prediction rule, risk assessment, clinical probability, pretest probability, diagnostic score and medical Subject Heading terms: 'Venous Thromboembolism/diagnosis' OR 'Venous Thrombosis/diagnosis'. Both development and validation studies were eligible for inclusion. Results The search strategy returned a total of 2036 articles, of which 102 articles met a priori criteria for inclusion. Eight different diagnostic scores were identified. The development of these scores differs in respect of the population included (hospital inpatients, hospital outpatients or primary care patients), the exclusion criteria, the inclusion of distal deep vein thrombosis and the use of D-dimer. The reliability and applicability of the scores in the context of specific subgroups (inpatients, cancer patients, elderly patients and those with recurrent deep vein thrombosis) remains controversial. Conclusion Detailed knowledge of the development of the various clinical prediction scores for deep vein thrombosis is essential in understanding the power, generalisability and limitations of these clinical tools.

show abstract

“…Importantly, the detachment of thrombosis can migrate to brain or lung to induce pulmonary thromboembolism or cerebral thromboembolism, which severely threatens patient's life . Though DVT can be diagnosed based on clinical manifestation, such as imaging/lab results and body signs, frequent misdiagnosis in clinics was made since 70%‐80% of DVT patients had no clinical symptoms at early stage due to slow and insidious onset . Veins that recanalize more rapidly have better‐preserved valve integrity and a lower incidence of reflux and patients with shorter recanalization times have been shown to have an improved clinical outcome .…”

Section: Introductionmentioning

confidence: 99%

Bone marrow stromal cells transplantation promotes the resolution and recanalization of deep vein thrombosis in rabbits through regulating macrophage infiltration and angiogenesis

Zhang

Kong

Jin

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

This study aims to validate whether bone marrow stromal cells (BMSCs) transplantation could promote the resolution and recanalization of deep vein thrombosis (DVT) and to explore the underlying mechanism. The right hind femoral vein was embolized to establish the DVT rabbit model. BMSCs from New Zealand white rabbits were isolated and identified, and then injected into DVT rabbits. After that, the extent of angiogenesis was determined by the amount of capillaries that were positive for antibody against vWF. Macrophage infiltration was measured by immunohistochemistry with F4/80 antibody. M1 or M2 macrophages were identified as F4/80 + CD11c + or F4/80 + CD206 + cells by using flow cytometry analysis, respectively. BMSCs were successfully isolated and identified. BMSCs transplantation promotes macrophage infiltration and angiogenesis in DVT rabbits. BMSCs transplantation causes M1/M2 polarization, altered cytokine production and increased monocyte chemotactic protein 1 (MCP-1) protein expression in DVT rabbits. However, injection of MCP-1 protein not only reversed the effects of BMSCs transplantation on macrophage infiltration and angiogenesis, but also reversed the effects of BMSCs transplantation on M1/M2 polarization and cytokine production in DVT rabbits. BMSCs transplantation promotes the resolution and recanalization of DVT in rabbits through regulating macrophage infiltration and angiogenesis, the underlying mechanism is associated with MCP-1 expression.

show abstract

Comparison of clinical prediction scores for the diagnosis of deep vein thrombosis in unselected population of outpatients and inpatients

Abstract: The modified Wells and the Constans score appear to be useful in the unselected population of outpatients and inpatients and particularly in the outpatient subgroup.

Cited by 7 publications

References 12 publications

Deep Vein Thrombosis in Pregnancy: A Review Article

Deep Vein Thrombosis in Pregnancy: A Review Article

A systematic review of clinical prediction scores for deep vein thrombosis

Bone marrow stromal cells transplantation promotes the resolution and recanalization of deep vein thrombosis in rabbits through regulating macrophage infiltration and angiogenesis

Contact Info

Product

Resources

About