Comparison of clinical outcomes of different components of diabetic macular edema on optical coherence tomography

Hu, Yijun; Wu, Qiaowei; Cao, Dan; Dong, Xiao; Zhang, Liang; Li, Tao; Yang, Xiaohong; Yu, Honghua

doi:10.1007/s00417-019-04471-3

Cited by 10 publications

(14 citation statements)

References 27 publications

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Section: Introductionmentioning

confidence: 99%

“…Serous RD (SRD) is a subgroup of RD commonly seen in central serous chorioretinopathy (CSC) and diabetic macular edema (DME) [10,11]. DME with coexisting SRD (SRD-DME) can be observed in the OCT images of DME patients [10]. Photoreceptor damage can also be seen in eyes with SRD-DME and the photoreceptors can be restored after resolution of the DME [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Restoration of Foveal Bulge after Resolution of Diabetic Macular Edema with Coexisting Serous Retinal Detachment

Huang

et al. 2020

Journal of Diabetes Research

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Purpose. To evaluate the impact of restoration of foveal bulge (FB) in optical coherence tomography (OCT) images on visual acuity after resolution of diabetic macular edema with coexisting serous retinal detachment (SRD-DME). Methods. A total of 52 eyes with resolved SRD-DME and an intact ellipsoid zone at the central fovea were included. All eyes underwent best-corrected visual acuity (BCVA) examination and OCT scanning at baseline and follow-up visits (1, 3, and 6 months). The eyes were divided into two groups according to the presence of FB at 6 months. BCVA, central foveal thickness (CFT), height of SRD (SRDH), outer nuclear layer (ONL) thickness, photoreceptor inner segment (PIS), and outer segment (POS) length were compared between the two groups. Results. A FB was found in 25 of 52 (48%) eyes at 6 months. The FB (+) group had lower SRDH at baseline, and better BCVA, longer POS length at 6 months (all P<0.05). There was no significant difference in the CFT, ONL thickness, and PIS length at 6 months between the two groups (all P>0.05). More eyes in the FB (+) group had complete SRD resolution at 1 month (P=0.009) and 3 months (P=0.012). Eyes with complete SRD resolution at 1 month (P=0.009) or 3 months (P=0.012) were more likely to have a FB at 6 months. Conclusions. The Presence of the FB is associated with better BCVA after resolution of SRD-DME. Eyes with lower baseline SRDH or faster SRD resolution are more likely to have a FB at 6 months.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Restoration of Foveal Bulge after Resolution of Diabetic Macular Edema with Coexisting Serous Retinal Detachment

Huang

et al. 2020

Journal of Diabetes Research

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“…We included eyes that were untreated or received previous anti-vascular endothelial growth factor (VEGF) or pan-retinal photocoagulation (PRP) at least 6 months ago and eyes with the central foveal thickness (CFT) over 275 µm and BCVA between 0.3 and 1.0 logarithm of the minimal angle of resolution (LogMAR) (20/200-20/40) at baseline (12,19). Eyes with macular edema secondary to other causes, such as retinal artery/vein occlusion, age-related macular degeneration, and polypoidal choroidal vasculopathy, eyes with macular ischemia, glaucoma or IOP > 21 mmHg, a history of macular grid photocoagulation or vitrectomy, refractive error over 6 diopters (D), severe cataracts, or previously treated with PRP or intravitreal or periocular injection <6 months were excluded (12,17). We also excluded eyes with unsatisfactory SD-OCT images resulting from poor patient cooperation or media opacity.…”

Section: Subjectsmentioning

confidence: 99%

“…All included eyes received a loading dose of 3 monthly consecutive 0.5-mg intravitreal injections of ranibizumab (IVR) treatment. After the loading treatment, patients were followed on monthly basis and received 1 IVR injection if they met any of the following criteria: (A) CFT increases by ≥ 100 µm; (B) BCVA decreases by ≥ 0.1 LogMAR; or (C) the decrease of BCVA attributed to newly formed SRD or intraretinal cyst, based on the surgeons; or (D) the decrease of BCVA due to enlargement of previous SRD or intraretinal cyst, based on the surgeons (9,12,17). IVR injection was suspended if either of the following criteria was met: (A) BCVA ≤ 0.0 LogMAR (20/20) observed at the two last consecutive follow-ups; or (B) stable BCVA over three consecutive follow-ups that include the current follow-up evaluation, specifically no improvement of BCVA due to IVR injections at the two last consecutive follow-ups (9,12,17).…”

Section: Treatmentmentioning

confidence: 99%

“…For example, SRD mainly involves the disruption of outer blood-retinal barriers (BRB), whereas DRT and CME are caused by the breakdown of inner BRB (9,15,16). Therefore, these DME types can be further classified into SRD and non-SRD (i.e., DRT and CME) categories according to their different pathogenesis (17). Our previous study has demonstrated the association between the restoration of FB and severity of SRD in eyes with resolved SRD-DME (12), but the effect of non-SRD on the restoration of FB is still unknown.…”

Section: Introductionmentioning

confidence: 99%

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Factors Associated With the Presence of Foveal Bulge in Eyes With Resolved Diabetic Macular Edema

Lin

et al. 2022

Front. Med.

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Purpose: To evaluate factors associated with the presence of foveal bulge (FB) in resolved diabetic macular edema (DME) eyes.Methods: A total of 165 eyes with complete integrity of ellipsoid zone (EZ) at the fovea and resolved DME were divided into two groups according to the presence of FB at 6 months after intravitreal injection of ranibizumab treatment. Best-corrected visual acuity (BCVA), central foveal thickness (CFT), outer nuclear layer (ONL) thickness, height of serous retinal detachment (SRD) and non-SRD, and inner segment (IS) and outer segment (OS) lengths of the two groups were measured and compared at baseline and each follow-up. The correlations between the presence of FB and pre- and post-treatment factors were determined by logistic regression analysis.Results: At baseline, BCVA was significantly better, and CFT and incidence and height of SRD were significantly lower in the FB (+) group (all P < 0.05). At 6 months, FB was present in 65 (39.39%) eyes. Post-treatment BCVA was significantly better and OS length was significantly longer in the FB (+) group at 6 months (all P < 0.05). Multivariate analysis identified younger age, better BCVA, and lower CFT before treatment as significant predictors of the existence of FB at 6 months (all P < 0.05). At 6 months, better BCVA and longer OS length were significantly correlated with the existence of FB (all P < 0.05).Conclusions: Factors associated with the presence of FB after the resolution of DME include younger age, better baseline BCVA and lower baseline CFT, and better post-treatment BCVA and longer post-treatment OS length.

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Evaluation of the efficacy of anti-vascular endothelial growth factors in diabetic macular edema with retinal inner and outer layers disorganization

Kocapınar

Kaplan

Sönmez³

et al. 2023

Acta Diabetol

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Comparison of clinical outcomes of different components of diabetic macular edema on optical coherence tomography

Cited by 10 publications

References 27 publications

Restoration of Foveal Bulge after Resolution of Diabetic Macular Edema with Coexisting Serous Retinal Detachment

Restoration of Foveal Bulge after Resolution of Diabetic Macular Edema with Coexisting Serous Retinal Detachment

Factors Associated With the Presence of Foveal Bulge in Eyes With Resolved Diabetic Macular Edema

Evaluation of the efficacy of anti-vascular endothelial growth factors in diabetic macular edema with retinal inner and outer layers disorganization

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