Comparison of clinical outcomes of squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma of the uterine cervix after definitive radiotherapy: a population-based analysis

Zhou, Juan; Wu, San‐Gang; Sun, Jiayuan; Li, Fengyan; Lin, Huan‐Xin; Chen, Qionghua; He, Zhenyu

doi:10.1007/s00432-016-2246-9

Cited by 68 publications

(81 citation statements)

References 34 publications

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“…A worse survival outcome was also associated with increasing age on multivariate analysis. In patients with non-specific pathological type of cervical cancer, the poor prognoses associated with increasing age have been reported in our previous studies [21, 22]. However, age had no significant prognostic value in other studies with SCCC subtype [8, 9, 11, 23].…”

Section: Discussionmentioning

confidence: 63%

Clinicopathological features of small cell carcinoma of the uterine cervix in the surveillance, epidemiology, and end results database

Zhou

Sun

et al. 2017

Oncotarget

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To investigate the clinicopathological characteristics and survival of small cell carcinoma of the cervix using Surveillance, Epidemiology, and End Results database. Patients with a diagnosis of small cell carcinoma of the cervix were included between 1988 and 2012. Kaplan-Meier method and Cox regression models were used. A total of 487 patients were included. Of the patients with known International Federation of Gynecology and Obstetrics stage and tumor grade, the stage IV disease was diagnosed in 37.9% patients, and 98.5% patients had poorly or undifferentiated histology. The 5-year cause specific survival and overall survival were 33.0% and 29.4%, respectively. In multivariate analysis, increasing age, advanced stage, and treatment by primary radiotherapy were associated with worse survival outcomes. Small cell carcinoma of the cervix is a rare disease with aggressive characteristics and prone to metastasize and is dismal in prognosis. Reduced survival was associated with increasing age, advanced stage, and treatment by primary radiotherapy.

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Section: Discussionmentioning

confidence: 63%

Clinicopathological features of small cell carcinoma of the uterine cervix in the surveillance, epidemiology, and end results database

Zhou

Sun

et al. 2017

Oncotarget

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“…Cervical SCC, ASC and AC exhibit different biological behaviors and varied clinical outcomes [21, 22]. Research into the number of positive LNs in different histological types of cervical cancer is limited.…”

Section: Discussionmentioning

confidence: 99%

Incorporation of the number of positive lymph nodes leads to better prognostic discrimination of node-positive early stage cervical cancer

Zhou

Sun

et al. 2017

Oncotarget

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To determine the prognostic value of the number of positive lymph nodes (LNs) in cervical cancer and further stratify patients with positive LNs into multiple risk groups based on analysis of Surveillance Epidemiology and End Results (SEER) program. Patients with cervical cancer who undergo hysterectomy and had pathologically-confirmed positive LNs after lymphadenectomy were identified using the SEER database (1988-2012). Kaplan–Meier survival methods and Cox proportional hazards regression were performed. We included 2,222 patients with the median number of removed LNs and positive LNs was 22 and 2, respectively. Multivariable Cox analysis showed patients with > 2 positive LNs had poorer cause-specific survival (CSS) (hazard ratio [HR] 1.631, 95% confidence interval [CI] 1.382–1.926, P < 0.001) and overall survival (OS) (HR 1.570, 95% CI 1.346–1.832, P < 0.001) than patients with 1–2 positive LNs. Five-year CSS and OS were 78.9% vs. 65.5% (P < 0.001) and 76.7% vs. 62.7% (P < 0.001) for 1–2 positive LNs and > 2 positive LNs, respectively. The number of positive LNs had prognostic value in cervical squamous cell carcinoma or adenosquamous carcinoma, but not in cervical adenocarcinoma. The number of positive LNs is an independent risk factor for CSS and OS in cervical cancer. This new category might be helpful in better prognostic discrimination of node-positive early stage cervical cancer after hysterectomy.

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“…Thorough resection of occult metastatic disease can give apparent benefits of extensive lymphadenectomy in cases with poorer outcomes. 4,10,11,25 Interestingly, the role of more extensive lymphadenectomy was apparent in the RHL-RT interval of greater than 31 days. This result suggests that less DPLN exacerbates locoregional control waiting for adjuvant RT and causing impairment of distant metastasis control.…”

Section: Discussionmentioning

confidence: 99%

Role of Extensive Lymphadenectomy in Early-Stage Cervical Cancer Patients With Radical Hysterectomy Followed by Adjuvant Radiotherapy

Tomita

Mizuno

Kondo

et al. 2018

International Journal of Gynecological Cancer

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Comparison of clinical outcomes of squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma of the uterine cervix after definitive radiotherapy: a population-based analysis

Abstract: AC and ASC subtypes are independent prognostic factors for cervical cancer patients treated with definitive radiotherapy. AC and ASC subtypes are associated with poor survival outcomes than those with SCC.

Cited by 68 publications

References 34 publications

Clinicopathological features of small cell carcinoma of the uterine cervix in the surveillance, epidemiology, and end results database

Clinicopathological features of small cell carcinoma of the uterine cervix in the surveillance, epidemiology, and end results database

Incorporation of the number of positive lymph nodes leads to better prognostic discrimination of node-positive early stage cervical cancer

Role of Extensive Lymphadenectomy in Early-Stage Cervical Cancer Patients With Radical Hysterectomy Followed by Adjuvant Radiotherapy

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